Optimising the choice between systemic and local therapies is one of the keystones in modern oncology. Better systemic therapeutic options have impressively been shown to prolong survival of patients but more and more the smart integration of local therapies into multimodal therapeutic approaches is taking treatment success to the next level. In this issue of
European Medical Oncology (
MEMO) [
3] three different tumours—prostate cancer, kidney cancer and squamous cell skin cancer—are highlighted for this strategy to boost therapeutic outcomes in oncology [
1]. …