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15.01.2020 | short review

Radiotherapy in soft tissue sarcoma

verfasst von: Prof. Dr. Falk Röder

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 2/2020

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Summary

Radiation therapy (RT) is an integral part of the treatment of adult soft tissue sarcomas (STS). In extremity STS, RT generally increases local control (LC) compared to wide excision alone while the magnitude of benefit depends on the individual risk profile. Neoadjuvant treatment results in less late toxicity paralleled by improved functional outcome but comes along with increased wound complications compared to postoperative radiation. In retroperitoneal sarcoma, neoadjuvant radiation seems to improve LC at least in liposarcomas while its impact in other histologies remains unclear. Postoperative radiation should not be used except in highly selected cases due to clear disadvantages regarding target coverage and side effects. The introduction of modern radiation techniques like intensity-modulated RT and image-guided RT has further improved the therapeutic ratio and is strongly recommended. Alternative boosting techniques like intraoperative RT or brachytherapy might be used to increase efficacy in high-risk patients although their value has not been proven in modern randomized trials.
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Metadaten
Titel
Radiotherapy in soft tissue sarcoma
verfasst von
Prof. Dr. Falk Röder
Publikationsdatum
15.01.2020
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 2/2020
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-019-00562-3

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