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Erschienen in: Wiener Medizinische Wochenschrift 3-4/2018

09.06.2017 | main topic

Psychoneuroimmunology—developments in stress research

verfasst von: Rainer H Straub, Maurizio Cutolo

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 3-4/2018

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Summary

Links between the central nervous stress system and peripheral immune cells in lymphoid organs have been detailed through 50 years of intensive research. The brain can interfere with the immune system, where chronic psychological stress inhibits many functions of the immune system. On the other hand, chronic peripheral inflammation—whether mild (during aging and psychological stress) or severe (chronic inflammatory diseases)—clearly interferes with brain function, leading to disease sequelae like fatigue but also to overt psychiatric illness. In recent years, it has been observed that psychological stress can be disease permissive, as in chronic inflammatory diseases, cancer, cardiovascular diseases, acute and chronic viral infections, sepsis, asthma, and others. We recognized that stress reactivity is programmed for a lifetime during a critical period between fetal life and early childhood, which then influences stress behavior and stress responses in adulthood. First phase II clinical studies, e.g., on cognitive behavioral therapy and mind–body therapies (e. g., mindfulness-based stress reduction), are available that show some benefits in stressful human diseases such as breast cancer and others. The field of psychoneuroimmunology has reached a firm ground and invites therapeutic approaches based on Good Clinical Practice phase III multicenter randomized controlled trials to influence stress responses and outcome in chronic illness.
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Metadaten
Titel
Psychoneuroimmunology—developments in stress research
verfasst von
Rainer H Straub
Maurizio Cutolo
Publikationsdatum
09.06.2017
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 3-4/2018
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-017-0574-2