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Erschienen in: European Surgery 2/2023

13.02.2023 | original article

Pseudoaneurysms after curative-aim gastrectomy for gastric carcinoma: clinical presentation and management

verfasst von: Pietro Santocchi, MD, Flavio Tirelli, MD, Roberto Persiani, MD, FACS, Antonio Laurino, MD, Francesco Belia, MD, Annamaria Agnes, MD, Laura Lorenzon, MD, PhD, Domenico D’Ugo, MD, Alberto Biondi, MD, FACS

Erschienen in: European Surgery | Ausgabe 2/2023

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Summary

Background

Postoperative bleeding after gastrectomy is a rare but life-threatening complication. Most cases develop from the celiac trunk or hepatic artery branches in the early postoperative period, or as late bleeding even weeks after surgery. The main cause is believed to be arterial damage during lymphadenectomy. Arterial pseudoaneurysms are a risk factor for late abdominal bleeding after curative-aim gastrectomy. In this study, we describe the clinical management and treatment options of this condition.

Methods

We evaluated the incidence of pseudoaneurysms among a 10-year series of patients undergoing curative-aim gastrectomy. To establish the incidence of pseudoaneurysms and their impact on clinical practice, we reviewed the clinical follow-up data of all patients and the CT scans performed during follow-up. The CT scan review was aimed at identifying new-onset vascular abnormalities. A total of 156 patients were included.

Results

The overall incidence of postoperative pseudoaneurysms was 3.2%. A D2 or D2+ lymphadenectomy was performed in 131 cases. The incidence of postoperative bleeding due to ruptured pseudoaneurysm was 1.9%. Interventional radiology was the first treatment line for hemodynamically stable patients and had a 50% success rate. Radiological treatments were represented by embolization with coils and glue, or metallic stent placement.

Conclusion

The extent of lymphadenectomy and the neoadjuvant treatments did not seem to have an impact on the onset of pseudoaneurysms. Surgical site infections represent a significant risk factor for pseudoaneurysm rupture. Radiological treatment could be safely performed in hemodynamically stable patients and represented a feasible alternative to surgery.
Literatur
1.
Zurück zum Zitat Yang J, Zhang XH, Huang YH, et al. Diagnosis and treatment of abdominal arterial bleeding after radical gastrectomy: a retrospective analysis of 1875 consecutive resections for gastric cancer. J Gastrointest Surg. 2016;20(3):510–20.CrossRefPubMed Yang J, Zhang XH, Huang YH, et al. Diagnosis and treatment of abdominal arterial bleeding after radical gastrectomy: a retrospective analysis of 1875 consecutive resections for gastric cancer. J Gastrointest Surg. 2016;20(3):510–20.CrossRefPubMed
2.
Zurück zum Zitat Tajima Y, Kuroki T, Tsutsumi R, et al. Extrahepatic collaterals and liver damage in embolotherapy for ruptured hepatic artery pseudoaneurysm following hepatobiliary pancreatic surgery. World J Gastroenterol. 2007;13(3):408–13.CrossRefPubMedPubMedCentral Tajima Y, Kuroki T, Tsutsumi R, et al. Extrahepatic collaterals and liver damage in embolotherapy for ruptured hepatic artery pseudoaneurysm following hepatobiliary pancreatic surgery. World J Gastroenterol. 2007;13(3):408–13.CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Noun R, Zeidan S, Tohme-Noun C, et al. Biliary ischemia following embolization of a pseudoaneurysm after pancreaticoduodenectomy. JOP. 2006;7(4):427–31.PubMed Noun R, Zeidan S, Tohme-Noun C, et al. Biliary ischemia following embolization of a pseudoaneurysm after pancreaticoduodenectomy. JOP. 2006;7(4):427–31.PubMed
4.
Zurück zum Zitat Kim DY, Joo JK, Ryu SY, et al. Pseudoaneurysm of gastroduodenal artery following radical gastrectomy for gastric carcinoma patients. World J Gastroenterol. 2003;9(12):2878–9.CrossRefPubMedPubMedCentral Kim DY, Joo JK, Ryu SY, et al. Pseudoaneurysm of gastroduodenal artery following radical gastrectomy for gastric carcinoma patients. World J Gastroenterol. 2003;9(12):2878–9.CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Kunitomo A, Misawa K, Sato Y, et al. Gastroduodenal artery pseudoaneurysm hemorrhage 1 year after laparoscopic distal gastrectomy: a case report. Surg Case Rep. 2020;6(1):38.CrossRefPubMedPubMedCentral Kunitomo A, Misawa K, Sato Y, et al. Gastroduodenal artery pseudoaneurysm hemorrhage 1 year after laparoscopic distal gastrectomy: a case report. Surg Case Rep. 2020;6(1):38.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Namikawa T, Kobayashi M, Hanazaki K. Transcatheter arterial embolization of ruptured inferior phrenic artery pseudoaneurysm following completion gastrectomy. J Gastrointest Surg. 2015;19(8):1561–2.CrossRefPubMed Namikawa T, Kobayashi M, Hanazaki K. Transcatheter arterial embolization of ruptured inferior phrenic artery pseudoaneurysm following completion gastrectomy. J Gastrointest Surg. 2015;19(8):1561–2.CrossRefPubMed
7.
Zurück zum Zitat Funakoshi K, Ishibashi Y, Yoshimura S, et al. Right inferior phrenic artery pseudoaneurysm after a laparoscopic gastrectomy: a case report. Surg Case Rep. 2019;5(1):187.CrossRefPubMedPubMedCentral Funakoshi K, Ishibashi Y, Yoshimura S, et al. Right inferior phrenic artery pseudoaneurysm after a laparoscopic gastrectomy: a case report. Surg Case Rep. 2019;5(1):187.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2018 (5th edition). Gastric Cancer. 2021;24(1):1–21.CrossRef Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2018 (5th edition). Gastric Cancer. 2021;24(1):1–21.CrossRef
10.
Zurück zum Zitat Amin MB, Greene FL, Edge SB, et al. The eighth edition AJCC cancer staging manual: Continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin. 2017;67(2):93–9.CrossRefPubMed Amin MB, Greene FL, Edge SB, et al. The eighth edition AJCC cancer staging manual: Continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin. 2017;67(2):93–9.CrossRefPubMed
11.
Zurück zum Zitat Wente MN, Veit JA, Bassi C, et al. Postpancreatectomy haemorrhage (PPH)—An International Study Group of Pancreatic Surgery (ISGPS) definition. Surgery. 2007;142(1):20–512.CrossRefPubMed Wente MN, Veit JA, Bassi C, et al. Postpancreatectomy haemorrhage (PPH)—An International Study Group of Pancreatic Surgery (ISGPS) definition. Surgery. 2007;142(1):20–512.CrossRefPubMed
12.
Zurück zum Zitat Chen L, Ming X, Gu R, et al. Treatment experience of delayed massive gastrointestinal bleeding caused by intra-abdominal arteriointestinal fistula in gastric cancer patients after radical gastrectomy. World J Surg Oncol. 2019;17(1):201.CrossRefPubMedPubMedCentral Chen L, Ming X, Gu R, et al. Treatment experience of delayed massive gastrointestinal bleeding caused by intra-abdominal arteriointestinal fistula in gastric cancer patients after radical gastrectomy. World J Surg Oncol. 2019;17(1):201.CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Brodie B, Kocher HM. Systematic review of the incidence, presentation and management of gastroduodenal artery pseudoaneurysm after pancreatic resection. BJS Open. 2019;3(6):735–42.CrossRefPubMedPubMedCentral Brodie B, Kocher HM. Systematic review of the incidence, presentation and management of gastroduodenal artery pseudoaneurysm after pancreatic resection. BJS Open. 2019;3(6):735–42.CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Li Z, Jie Z, Liu Y, Xie X. Management of delayed hemorrhage following radical gastrectomy for gastric carcinoma patients. Hepatogastroenterology. 2012;59(118):2016–9.PubMed Li Z, Jie Z, Liu Y, Xie X. Management of delayed hemorrhage following radical gastrectomy for gastric carcinoma patients. Hepatogastroenterology. 2012;59(118):2016–9.PubMed
15.
Zurück zum Zitat Björck M, Koelemay M, Acosta S, et al. Editor’s choice—Management of the diseases of mesenteric arteries and veins. Eur J Vasc Endovasc Surg. 2017;53:460–510.CrossRefPubMed Björck M, Koelemay M, Acosta S, et al. Editor’s choice—Management of the diseases of mesenteric arteries and veins. Eur J Vasc Endovasc Surg. 2017;53:460–510.CrossRefPubMed
16.
Zurück zum Zitat Lee HJ, Hyung WJ, Yang HK, et al. Short-term outcomes of a multicenter randomized controlled trial comparing laparoscopic distal gastrectomy with D2 lymphadenectomy to open distal gastrectomy for locally advanced gastric cancer (KLASS-02-RCT). Ann Surg. 2019;270(6):983–91.CrossRefPubMed Lee HJ, Hyung WJ, Yang HK, et al. Short-term outcomes of a multicenter randomized controlled trial comparing laparoscopic distal gastrectomy with D2 lymphadenectomy to open distal gastrectomy for locally advanced gastric cancer (KLASS-02-RCT). Ann Surg. 2019;270(6):983–91.CrossRefPubMed
17.
Zurück zum Zitat Jin HE, Kim MS, Lee CM, et al. Meta-analysis and systematic review on laparoscopic-assisted distal gastrectomy (LADG) and totally laparoscopic distal gastrectomy (TLDG) for gastric cancer: Preliminary study for a multicentre prospective KLASS07 trial. Eur J Surg Oncol. 2019;45(12):2231–40.CrossRefPubMed Jin HE, Kim MS, Lee CM, et al. Meta-analysis and systematic review on laparoscopic-assisted distal gastrectomy (LADG) and totally laparoscopic distal gastrectomy (TLDG) for gastric cancer: Preliminary study for a multicentre prospective KLASS07 trial. Eur J Surg Oncol. 2019;45(12):2231–40.CrossRefPubMed
18.
Zurück zum Zitat Li Z, Shan F, Wang Y, et al. Laparoscopic versus open distal gastrectomy for locally advanced gastric cancer after neoadjuvant chemotherapy: safety and short-term oncologic results. Surg Endosc. 2016;30(10):4265–71.CrossRefPubMed Li Z, Shan F, Wang Y, et al. Laparoscopic versus open distal gastrectomy for locally advanced gastric cancer after neoadjuvant chemotherapy: safety and short-term oncologic results. Surg Endosc. 2016;30(10):4265–71.CrossRefPubMed
19.
Zurück zum Zitat Fujisaki M, Mitsumori N, Shinohara T, et al. Short- and long-term outcomes of laparoscopic versus open gastrectomy for locally advanced gastric cancer following neoadjuvant chemotherapy. Surg Endosc. 2021;35(4):1682–90.CrossRefPubMed Fujisaki M, Mitsumori N, Shinohara T, et al. Short- and long-term outcomes of laparoscopic versus open gastrectomy for locally advanced gastric cancer following neoadjuvant chemotherapy. Surg Endosc. 2021;35(4):1682–90.CrossRefPubMed
20.
Zurück zum Zitat Beyer K, Baukloh AK, Kamphues C, et al. Laparoscopic versus open gastrectomy for locally advanced gastric cancer: a systematic review and meta-analysis of randomized controlled studies. World J Surg Oncol. 2019;17(1):68.CrossRefPubMedPubMedCentral Beyer K, Baukloh AK, Kamphues C, et al. Laparoscopic versus open gastrectomy for locally advanced gastric cancer: a systematic review and meta-analysis of randomized controlled studies. World J Surg Oncol. 2019;17(1):68.CrossRefPubMedPubMedCentral
21.
23.
Zurück zum Zitat Devassy R, Hanif S, Krentel H, et al. Laparoscopic ultrasonic dissectors: technology update by a review of literature. Med Devices Evid Res. 2019;12:1–7.CrossRef Devassy R, Hanif S, Krentel H, et al. Laparoscopic ultrasonic dissectors: technology update by a review of literature. Med Devices Evid Res. 2019;12:1–7.CrossRef
24.
Zurück zum Zitat Lam S, Tan E, Menezes A, et al. A comparison of the operative outcomes of D1 and D2 gastrectomy performed at a single Western center with multiple surgeons: a retrospective analysis with propensity score matching. World J Surg Oncol. 2018;16(1):136.CrossRefPubMedPubMedCentral Lam S, Tan E, Menezes A, et al. A comparison of the operative outcomes of D1 and D2 gastrectomy performed at a single Western center with multiple surgeons: a retrospective analysis with propensity score matching. World J Surg Oncol. 2018;16(1):136.CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Sano T, Sasako M, Yamamoto S, et al. Gastric cancer surgery: morbidity and mortality results from a prospective randomized controlled trial comparing D2 and extended para-aortic lymphadenectomy—Japan clinical oncology group study 9501. J Clin Oncol. 2004;22(14):2767–73.CrossRefPubMed Sano T, Sasako M, Yamamoto S, et al. Gastric cancer surgery: morbidity and mortality results from a prospective randomized controlled trial comparing D2 and extended para-aortic lymphadenectomy—Japan clinical oncology group study 9501. J Clin Oncol. 2004;22(14):2767–73.CrossRefPubMed
26.
Zurück zum Zitat Degiuli M, Sasako M, Ponti A. Italian gastric cancer study group. Morbidity and mortality in the Italian gastric cancer study group randomized clinical trial of D1 versus D2 resection for gastric cancer. Br J Surg. 2010;97(5):643–9.CrossRefPubMed Degiuli M, Sasako M, Ponti A. Italian gastric cancer study group. Morbidity and mortality in the Italian gastric cancer study group randomized clinical trial of D1 versus D2 resection for gastric cancer. Br J Surg. 2010;97(5):643–9.CrossRefPubMed
27.
Zurück zum Zitat Barrionuevo P, Malas MB, Nejim B, et al. A systematic review and meta-analysis of the management of visceral artery aneurysms. J Vasc Surg. 2020;72(1S):40S–5S.CrossRefPubMed Barrionuevo P, Malas MB, Nejim B, et al. A systematic review and meta-analysis of the management of visceral artery aneurysms. J Vasc Surg. 2020;72(1S):40S–5S.CrossRefPubMed
28.
Zurück zum Zitat Obara H, Kentaro M, Inoue M, et al. Current management strategies for visceral artery aneurysms: an overview. Surg Today. 2020;50(1):38–49.CrossRefPubMed Obara H, Kentaro M, Inoue M, et al. Current management strategies for visceral artery aneurysms: an overview. Surg Today. 2020;50(1):38–49.CrossRefPubMed
Metadaten
Titel
Pseudoaneurysms after curative-aim gastrectomy for gastric carcinoma: clinical presentation and management
verfasst von
Pietro Santocchi, MD
Flavio Tirelli, MD
Roberto Persiani, MD, FACS
Antonio Laurino, MD
Francesco Belia, MD
Annamaria Agnes, MD
Laura Lorenzon, MD, PhD
Domenico D’Ugo, MD
Alberto Biondi, MD, FACS
Publikationsdatum
13.02.2023
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 2/2023
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-023-00794-y

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