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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2011; 32(02): 92-95
DOI: 10.4103/0971-5851.89786
ORIGINAL ARTICLE

Primary pediatric gastrointestinal lymphoma

Ranjana Bandyopadhyay
Department of Pathology, Burdwan Medical College, Kolkata, India
,
Swapan Kumar Sinha
Department of Pathology,Medical College, Kolkata, India
,
Uttara Chatterjee
Institute of Postgraduate Medical Education & Research, Kolkata, West Bengal, India
,
Dipanwita Nag
Department of Pathology,Medical College, Kolkata, India
,
Subhalakshmi Mukhopadhyay
Department of Pathology,Medical College, Kolkata, India
,
Supriyo Roy Chowdhury
Department of Pathology,Medical College, Kolkata, India
,
Pranab K Biswas
Department of Pathology,Medical College, Kolkata, India
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Abstract

Background: Primary non-Hodgkin′s lymphoma (NHL) of the gastrointestinal (GI) tract is the most common extranodal lymphoma in pediatric age group. Yet, the overall incidence is very low. The rarity of the disease as well as variable clinical presentation prevents early detection when the possibility of cure exists. Materials and Methods: We studied six cases of primary GI NHL in pediatric age group with reference to their clinical presentation, anatomic distribution and histopathologic characteristics. Results: All were males except one. Intestinal obstruction was the presenting feature in 50%. Half the cases showed ileocaecal involvement, while large bowel was involved in 16%. Histology showed four cases of diffuse large B-cell lymphoma (DLBCL), one case of Burkitt lymphoma, and one Burkitt-like lymphoma. Immunohistochemistry for Tdt, CD20, CD3, CD30, bcl2, bcl6 confirmed the morphological diagnosis. Conclusion: Pediatric GI lymphoma commonly involves the ileocaecal region and presents with intestinal obstruction. A higher prevalence of DLBCL is found compared to other series. A high proliferative index is useful in differentiating Burkitt-like lymphoma from DLBCL.

Keywords

Gastrointestinal tract - non-Hodgkin′s lymphoma - pediatric


Publication History

Article published online:
06 August 2021

© 2011. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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