Download PDF
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2009; 30(01): 24-27
DOI: 10.4103/0971-5851.56332
CASE REPORT

Adrenocortical carcinoma with skeletal metastases in a postmenopausal woman

Shila Mitra
Department of Radiotherapy, Medical College Hospital, 88, College Street, Kolkata - 700 073, India
,
Suparna Ghosh Roy
Department of Radiotherapy, Medical College Hospital, 88, College Street, Kolkata - 700 073, India
,
Prabir Kumar Sur
Department of Radiotherapy, Medical College Hospital, 88, College Street, Kolkata - 700 073, India
› Author Affiliations
› Further Information
  PDF Download Permissions and Reprints

Abstract

Adrenocortical cancer is a very rare tumor with a poor prognosis. About half of them are hormone-secreting tumors. In most cases, hormonal investigations reveal an excess secretion of steroids, mostly cortisol and androgens. A 54-year-old lady presented with history of pain in left shoulder and leg for 6 months and features of virilization. CT-guided fine-needle aspiration cytology of an abdominal mass revealed the presence of a carcinoma of the left adrenal cortex. A whole-body radionuclide bone scan revealed increased uptake in the left clavicle and left femur. The patient has received palliative radiotherapy for the skeletal lesions and 3 cycles of palliative chemotherapy at present.

Keywords

Adrenocortical carcinoma - androgen secreting tumors - mitotane


Publication History

Article published online:
19 November 2021

© 2009. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Fassanacht M, Hahner S, Polat B, Koschker AC, Kenn W, Flentje M, et al. Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma. J Clin Endocr Metab 2006;91:4501-4.
  • 2 Allolio B, Fassanacht M. Clinical review: Adrenocortical carcinoma: Clinical update. J Clin Endocr Metab 2006;91: 2027-37.
  • 3 Norton JA. Adrenal tumors. In: Devita VT, Hellman S, Rosenberg SA, editors. Cancer, Principles and practice of oncology. 7 th ed. Philadelphia: Pub. Lippincott;. 2005. p. 1528-34.
  • 4 Fraker D. In: Devita VT, Lawrence T, Rosenberg SA, editors. Cancer, principles and practice of oncology. 8 th ed. Philadelphia: Pub. Lippincott; 2008. p. 1690-7.
  • 5 Schteingart DE, Doherty GM, Gauger PG. Management of patients with adrenal cancer: Recommendations of an internal consensus conference. Endocr Relat Cancer 2005;12:667-80.
  • 6 Libe R, Fratticci A, Bertherat J. Adrenocortical cancer: Pathophysiology and clinical management. Endocr Relat Cancer 2007;14:13-28.
  • 7 Cordera F, Grant C, van Heerden J, Thompson G, Young W. Androgen secreting adrenal tumors. Surgery 2003;134:874-900.
  • 8 Assie G, Antoni G, Tissier F, Caillou B, Abiven G, Gicquel C, et al. Prognostic parameters of metastatic adernocortical carcinoma. J Clin Endocr Metab 2006;92:148-54.
  • 9 Kirschner L. Paradigms for adrenal cancer: Think globally, act locally. J Clin Endocr Metab 2006;91:4250-2.
  • 10 Terzolo M, Angeli A, Fassnatch M, Daffara F, Tauchmanova L, Conton PA, et al. Adjuvant mitotane treatment for adrenocortical carcinoma. N Engl J Med 2007;356:2372-80.