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Planta Med 1980; 39(5): 19-23
DOI: 10.1055/s-2008-1074899
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Inhibition of Type A and Type B Monoamine Oxidase by Isogentisin and its 3-O-Glucoside

O. Suzuki1 , Y. Katsumata2 , M. Oya2 , V. M. Chari3 , R. Klapfenberger3 , H. Wagner3 , K. Hostettmann4
  • 1Department of Legal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
  • 2Department of Legal Medicine, Nagoya University School of Medicine, Nagoya, Japan
  • 3Institut für Pharmazeutische Arzneimittellehre der Universität München, München, BRD
  • 4Pharmazeutisches Institut, Eidgenössische Technische Hochschule Zürich, Switzerland
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Publication History

Publication Date:
29 April 2008 (online)

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Abstract

Isogentisin and its 3-O-glucoside were found to inhibit monoamine oxidase (MAO) in rat brain mitochondria in vitro using 5-hydroxytryptamine (5-HT) and (3-phenylethylamine (PEA) as relatively specific substrates for type A and type B MAO, respectively. Isogentisin showed much more potent MAO inhibition than its 3-O-glucoside for both substrates. The inhibition by both compounds was fully competitive for both substrates. Both compounds were found to be almost nonselective inhibitors for type A and type B MAO. popular medicine both in Europe and Asia due to their unique actions on the central nervous system [2]. In our previous preliminary communication [3], we briefly reported that isogentisin and its 3-O-glucoside inhibit monoamine oxidase (MAO) in vitro using kynuramine as substrate. Since mitochondrial MAO is believed to exist in many animal tissues in two functional forms called type A and type B [4-6], in the present paper we have studied MAO inhibition by isogentisin and its 3-O-glucoside using 5-hydroxytryptamine (5-HT) and (3-phenylethylamine (PEA) as relatively specific substrates for type A and type B MAO, respectively.

Key Word Index

Isogentisin - lsogentisin-3-O-Glucoside - Xanthone Derivatives - Monoamine Oxidase Inhibition.

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