Zentralbl Chir 2007; 132(5): 400-410
DOI: 10.1055/s-2007-981269
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© Georg Thieme Verlag Stuttgart · New York

Wundinfektionen in der Viszeralchirurgie - Ätiologie, Risikofaktoren, Antibiotikaprophylaxe

Wound Infections in Abdominal Surgery - Aetiology, Risk Factors, Antibiotic ProphylaxisH. Wacha1
  • 1Hospital zum heiligen Geist, Akademisches Lehrkrankenhaus der JWG Universität Frankfurt, Frankfurt a. Main
Further Information

Publication History

Publication Date:
01 October 2007 (online)

Zusammenfassung

Nosokomiale Infektionen sind die Hauptursache für Morbidität und Mortalität im Krankenhaus. In Deutschland entwickeln 3,5 % der Patienten nosokomiale Infektionen, wovon 15 % Wundinfektionen nach chirurgischen Eingriffen sind. Asepsis, die adäquate chirurgische Technik und die Erkennung von Patienten mit einem Infektionsrisiko, sowie die adäquate Antibiotikaprophylaxe sind die effektivsten Maßnahmen, um postoperative Wundinfektionen zu reduzieren. Um Patienten mit einem Infektionsrisiko zu identifizieren, genügt die traditionelle Wundklassifikation nicht. Zusätzliche Risikofaktoren, die über die vermutete Keimkontaminationsrate am Ende einer Operation hinausgehen, müssen berücksichtigt werden. Indikation, die Wahl des Antibiotikums und der Applikationszeitpunkt werden aufgrund neuerer Literatur diskutiert.

Abstract

Nosocomial infections are the major cause for morbidity and mortality in hospital. In Germany 3.5 % of patients develope nosocomial infections, 15 % of these are wound infections post surgery. Asepsis, proper surgical technique and identifying patients at risk of infections and antibiotic prophylaxis are the most effective measures to reduce postoperative wound infection rate. To identify patients at risk by traditional wound classification system alone seems to be insufficient. Risk factors others than the suspected contamination rate at the end of the operation have to be detected. Indication, choice of the antibiotic agent and timing of antibiotic prophylaxis will be discussed.

Literatur

  • 1 Bundesgeschäftsstelle Qualitätssicherung .BQS Qualitätsreport 2004. Bundesgeschäftsstelle Qualitätssicherung, Düsseldorf 2004
  • 2 Alexander J W, Dellinger E P. Surgical Infections and Choice of Antibiotics. Saunders, Philadelphia 1991
  • 3 Almqvist P, Leandoer L, Tornqvist A. Timing of antibiotic treatment in non-perforated gangrenous appendicitis.  Eur J Surg. 1995;  161 431-433
  • 4 Aufenacker T J, van Geldere D, van Mesdag T, Bossers A N, Dekker B, Scheijde E. et al . The role of antibiotic prophylaxis in prevention of wound infection after Lichtenstein open mesh repair of primary inguinal hernia: a multicenter double-blind randomized controlled trial.  Ann Surg. 2004;  240 955-960 ,  discussion 960-951
  • 5 Barie P S. Surgical site infections: epidemiology and prevention.  Surg Infect (Larchmt). 2002;  3 (Suppl 1) 9-21
  • 6 Bates T, Siller G, Crathern B C, Bradley S P, Zlotnik R D, Couch C. et al . Timing of prophylactic antibiotics in abdominal surgery: trial of a pre-operative versus an intra-operative first dose.  Br J Surg. 1989;  76 52-56
  • 7 Biswas S. Elective inguinal hernia repair with mesh: is there a need for antibiotic prophylaxis? - A review.  World J Surg. 2005;  29 830-836
  • 8 Bratzler D W, Houck P M. Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project.  Clin Infect Dis. 2004;  38 1706-1715
  • 9 Bruce J, Krukowski Z H, Al-Khairy G, Russell E M, Park K G. Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery.  Br J Surg. 2001;  88 1157-1168
  • 10 Bucher P, Mermillod B, Morel P, Soravia C. Does mechanical bowel preparation have a role in preventing postoperative complications in elective colorectal surgery?.  Swiss Med Wkly. 2004;  134 69-74
  • 11 Burke J F. Preventing bacterial infection by coordinating antibiotic and host activity: a time-dependent relationship.  South Med J. 1977;  70 Suppl 1 24-26
  • 12 Chuang S C, Lee K T, Chang W T, Wang S N, Kuo K K, Chen J S. et al . Risk factors for wound infection after cholecystectomy.  J Formos Med Assoc. 2004;  103 607-612
  • 13 Classen D C, Evans R S, Pestotnik S L, Horn S D, Menlove R L, Burke J P. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection.  N Engl J Med. 1992;  326 281-286
  • 14 Colombo A ZG, Negri L, Scalambrino S, Pasta F. A randomized comparison of one-dose versus two-dose antibiotic prophylaxis in gynecologic surgery lasting over two hours.  J Gynaecol Obstet. 1998;  10 9-15
  • 15 Cruse P J, Foord R. A five-year prospective study of 23 649 surgical wounds.  Arch Surg. 1973;  107 206-210
  • 16 Culver D H, Horan T C, Gaynes R P, Martone W J, Jarvis W R, Emori T G. et al . Surgical wound infection rates by wound class, operative procedure, and patient risk index. National Nosocomial Infections Surveillance System.  Am J Med. 1991;  91 152 S-157 S
  • 17 Dietrich E S, Bieser U, Frank U, Schwarzer G, Daschner F D. Ceftriaxone versus other cephalosporins for perioperative antibiotic prophylaxis: a meta-analysis of 43 randomized controlled trials.  Chemotherapy. 2002;  48 49-56
  • 18 DiPiro J T, Cheung R P, Bowden Jr  T A, Mansberger J A. Single dose systemic antibiotic prophylaxis of surgical wound infections.  Am J Surg. 1986;  152 552-559
  • 19 Ebner W, Forster D H, Ruden H, Daschner F. [Evidence-based recommendations for perioperative antibiotic prophylaxis].  Chirurg. 2000;  71 912-917
  • 20 Finlay-Jones J JMP. Microorganisms in the pathogenesis of wound infection following abdominal surgery. Churchill Livingstone, Edinburg 1981
  • 21 Gastmeier P, Brandt C, Sohr D, Babikir R, Mlageni D, Daschner F. et al . [Surgical site infections in hospitals and outpatient settings. Results of the German nosocomial infection surveillance system (KISS)].  Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2004;  47 339-344
  • 22 Gaynes R P. Surgical-site infections (SSI) and the NNIS Basic SSI Risk Index, part II: room for improvement.  Infect Control Hosp Epidemiol. 2001;  22 266-267
  • 23 Gislason H, Soreide O, Viste A. Wound complications after major gastrointestinal operations. The surgeon as a risk factor.  Dig Surg. 1999;  16 512-514
  • 24 Gorecki P, Schein M, Rucinski J C, Wise L. Antibiotic administration in patients undergoing common surgical procedures in a community teaching hospital: the chaos continues.  World J Surg. 1999;  23 429-432 ,  discussion 433
  • 25 Gottrup F, Hunt T K. Antimicrobial prophylaxis in appendectomy patients.  World J Surg. 1982;  6 306-311
  • 26 Haley R W, Culver D H, Morgan W M, White J W, Emori T G, Hooton T M. Identifying patients at high risk of surgical wound infection. A simple multivariate index of patient susceptibility and wound contamination.  Am J Epidemiol. 1985;  121 206-215
  • 27 Higgins A, London J, Charland S, Ratzer E, Clark J, Haun W. et al . Prophylactic antibiotics for elective laparoscopic cholecystectomy: are they necessary?.  Arch Surg. 1999;  134 611-613 ,  discussion 614
  • 28 Illig K A, Schmidt E, Cavanaugh J, Krusch D, Sax H C. Are prophylactic antibiotics required for elective laparoscopic cholecystectomy?.  J Am Coll Surg. 1997;  184 353-356
  • 29 Kager L, Malmborg A S, Nord C E, Sjostedt S. The effect of piperacillin prophylaxis on the colonic microflora in patients undergoing colorectal surgery.  Infection. 1983;  11 251-254
  • 30 Kappstein I, Schulgen G, Richtmann R, Farthmann E H, Schlosser V, Geiger K. et al . [Prolongation of hospital stay by nosocomial pneumonia and wound infection].  Dtsch Med Wochenschr. 1991;  116 281-287
  • 31 Keighley M R, Winslet M C, Flinn R, Kmiot W. Multivariate analysis of factors influencing the results of restorative proctocolectomy.  Z Gastroenterol Verh. 1989;  24 252-255
  • 32 Knothe H. [Changes of the intestinal flora under influence of tetracycline therapy.].  Dtsch Med Wochenschr. 1957;  82 1685-1689
  • 33 Koch A, Zippel R, Marusch F, Schmidt U, Gastinger I, Lippert H. Prospective multicenter study of antibiotic prophylaxis in operative treatment of appendicitis.  Dig Surg. 2000;  17 370-378
  • 34 Kujat R, Grosse H, Gams E, Pichlmayr R. [Changes in water-electrolyte balance after orthograde intestinal irrigation].  Chirurg. 1981;  52 586-589
  • 35 Kuzu M A, Hazinedaroglu S, Dolalan S, Ozkan N, Yalcin S, Erkek A B. et al . Prevention of surgical site infection after open prosthetic inguinal hernia repair: efficacy of parenteral versus oral prophylaxis with amoxicillin-clavulanic acid in a randomized clinical trial.  World J Surg. 2005;  29 794-799
  • 36 Lewis R T, Weigand F M, Mamazza J, Lloyd-Smith W, Tataryn D. Should antibiotic prophylaxis be used routinely in clean surgical procedures: a tentative yes.  Surgery. 1995;  118 742-746 ,  discussion 746-747
  • 37 Linzenmeier G, Haralambie E, Dermoumi H. [Short-term oral chemoprophylaxis before intestine surgery. Quantitative determination of bacteria and fungi in stool specimens (author's transl)].  Zentralbl Bakteriol [Orig A]. 1979;  243 326-335
  • 38 Lizan-Garcia M, Garcia-Caballero J, Asensio-Vegas A. Risk factors for surgical-wound infection in general surgery: a prospective study.  Infect Control Hosp Epidemiol. 1997;  18 310-315
  • 39 Martin C, Pourriat J L. Quality of perioperative antibiotic administration by French anaesthetists.  J Hosp Infect. 1998;  40 47-53
  • 40 Martone W J, Nichols R L. Recognition, prevention, surveillance, and management of surgical site infections: introduction to the problem and symposium overview.  Clin Infect Dis. 2001;  33 Suppl 2 67-68
  • 41 Mc Ardle C S. Oral prophylaxis in biliary tract surgery.  J Antimicrob Chemother. 1994;  33 200-202
  • 42 McConkey S J, L'Ecuyer P B, Murphy D M, Leet T L, Sundt T M, Fraser V J. Results of a comprehensive infection control program for reducing surgical-site infections in coronary artery bypass surgery.  Infect Control Hosp Epidemiol. 1999;  20 533-538
  • 43 Medina M, Sillero M, Martinez-Gallego G, Delgado-Rodriguez M. Risk factors of surgical wound infection in patients undergoing herniorrhaphy.  Eur J Surg. 1997;  163 191-198
  • 44 Meijer W S, Schmitz P I, Jeekel J. Meta-analysis of randomized, controlled clinical trials of antibiotic prophylaxis in biliary tract surgery.  Br J Surg. 1990;  77 283-290
  • 45 Miransky J, Ruo L, Nicoletta S, Eagan J, Sepkowitz K, Margetson N. et al . Impact of a surgeon-trained observer on accuracy of colorectal surgical site infection rates.  Dis Colon Rectum. 2001;  44 1100-1105
  • 46 Muscroft T J, Deane S A. Prevention of sepsis in gastroesophageal surgery.  World J Surg. 1982;  6 293-300
  • 47 Nichols R L, Condon R E, Barie P S. Antibiotic prophylaxis in surgery - 2005 and beyond.  Surg Infect (Larchmt). 2005;  6 349-361
  • 48 Novelli A. Antimicrobial prophylaxis in surgery: the role of pharmacokinetics.  J Chemother. 1999;  11 565-572
  • 49 Platt R, Zaleznik D F, Hopkins C C, Dellinger E P, Karchmer A W, Bryan C S. et al . Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery.  N Engl J Med. 1990;  322 153-160
  • 50 Poulsen K B, Meyer M. Infection registration underestimates the risk of surgical wound infections.  J Hosp Infect. 1996;  33 207-215
  • 51 Raahave D, Friis-Moller A, Bjerre-Jepsen K, Thiis-Knudsen J, Rasmussen L B. The infective dose of aerobic and anaerobic bacteria in postoperative wound sepsis.  Arch Surg. 1986;  121 924-929
  • 52 Reid R, Simcock J W, Chisholm L, Dobbs B, Frizelle F A. Postdischarge clean wound infections: incidence underestimated and risk factors overemphasized.  ANZ J Surg. 2002;  72 339-343
  • 53 Ruden H, Gastmeier P, Daschner F D, Schumacher M. Nosocomial and community-acquired infections in Germany. Summary of the results of the First National Prevalence Study (NIDEP).  Infection. 1997;  25 199-202
  • 54 Schwarz M, Isenmann R, Thomsen J, Gaus W, Beger H G. Efficacy of oral ofloxacin for single-dose perioperative prophylaxis in general surgery - a controlled randomized clinical study.  Langenbecks Arch Surg. 2001;  386 397-401
  • 55 Schwenk W, Bohm B, Stock W. [Perioperative treatment in elective colorectal resection in Germany].  Zentralbl Chir. 1992;  117 403-411
  • 56 Soderquist-Elinder C, Hirsch K, Bergdahl S, Rutqvist J, Frenckner B. Prophylactic antibiotics in uncomplicated appendicitis during childhood - a prospective randomised study.  Eur J Pediatr Surg. 1995;  5 282-285
  • 57 Song F, Glenny A M. Antimicrobial prophylaxis in colorectal surgery: a systematic review of randomized controlled trials.  Br J Surg. 1998;  85 1232-1241
  • 58 Stock W, Hirt H J, Schaal K P, Pichlmaier H. [Preoperative reduction of intestinal bacteria through orthograde lavage of the large intestine].  Chirurg. 1977;  48 161-165
  • 59 Stone H H, Hooper C A, Kolb L D, Geheber C E, Dawkins E J. Antibiotic prophylaxis in gastric, biliary and colonic surgery.  Ann Surg. 1976;  184 443-452
  • 60 Swoboda S, Oberdorfer K, Klee F, Hoppe-Tichy T, Baum H von, Geiss H K. Tissue and serum concentrations of levofloxacin 500 mg administered intravenously or orally for antibiotic prophylaxis in biliary surgery.  J Antimicrob Chemother. 2003;  51 459-462
  • 61 Taylor E W, Byrne D J, Leaper D J, Karran S J, Browne M K, Mitchell K J. Antibiotic prophylaxis and open groin hernia repair.  World J Surg. 1997;  21 811-814 ,  discussion 814-815
  • 62 Tonz M, Schmid P, Kaiser G. Antibiotic prophylaxis for appendectomy in children: critical appraisal.  World J Surg. 2000;  24 995-998
  • 63 van Kasteren M E, Kullberg B J, de Boer A S, Mintjes-de Groot J, Gyssens I C. Adherence to local hospital guidelines for surgical antimicrobial prophylaxis: a multicentre audit in Dutch hospitals.  J Antimicrob Chemother. 2003;  51 1389-1396
  • 64 Vargish T, Crawford L C, Stallings R A, Wasilauskas B L, Myers R T. A randomized prospective evaluation of orally administered antibiotics in operations on the colon.  Surg Gynecol Obstet. 1978;  146 193-198
  • 65 Vogel F, Bodmann K.-F. Expertenkommission der Paul-Ehrlich-Gesellschaft . Empfehlungen zur kalkulierten parenteralen Initialtherapie bakterieller Erkrankungen bei Erwachsenen.  Chemotherapie Journal, ISSN 0940-6735.. 2004;  13 46-78
  • 66 Wacha H. Perioperative Antibiotika zur Verhütung bakterieller Infektionen.  Intensiv- u Notfallbehandlung. 2002;  1 / 2002 3-15
  • 67 Waltrip T, Lewis R, Young V, Farmer M, Clayton S, Myers S. et al . A pilot study to determine the feasibility of continuous cefazolin infusion.  Surg Infect (Larchmt). 2002;  3 5-9
  • 68 Wittmann D H, Welter J, Schassan H H. [Antibiotic concentrations in the abdominal cavity as basis for antibacterial therapy of peritonitis: penetration of mezlocillin into the peritoneal exudate].  Infection. 1982;  10 (Suppl 3) S 204-S 208
  • 69 Yerdel M A, Akin E B, Dolalan S, Turkcapar A G, Pehlivan M, Gecim I E. et al . Effect of single-dose prophylactic ampicillin and sulbactam on wound infection after tension-free inguinal hernia repair with polypropylene mesh: the randomized, double-blind, prospective trial.  Ann Surg. 2001;  233 26-33
  • 70 Zelenitsky S A, Ariano R E, Harding G K, Silverman R E. Antibiotic pharmacodynamics in surgical prophylaxis: an association between intraoperative antibiotic concentrations and efficacy.  Antimicrob Agents Chemother. 2002;  46 3026-3030

Prof. Dr. H. Wacha

Hospital zum heiligen Geist · Akademisches Lehrkrankenhaus der JWG Universität Frankfurt

Lange Straße 4-6

60311 Frankfurt a. Main

Phone: 0 69 / 21 96 24 30

URL: http://www.wacha@em.uni-frankfurt.de

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