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Pharmacopsychiatry 1995; 28(2): 51-55
DOI: 10.1055/s-2007-979588
© Georg Thieme Verlag Stuttgart · New York

Microstate Segmentation of Spontaneous Multichannel EEG Map Series under Diazepam and Sulpiride

T. Kinoshita1 , 2 , W. K. Strik1 , 3 , C. M. Michel1 , 4 , T. Yagyu2 , M. Saito2 , D. Lehmann1 , 5
  • 1EEC-EP Mapping Laboratories, Department of Neurology, University Hospital, Zurich, Switzerland
  • 2Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
  • 3University Hospital of Psychiatry, Würzburg, Germany
  • 4Functional Brain Mapping Laboratory, Department of Neurology, University Hospital, Geneva, Switzerland
  • 5KEY Institute for Brain-Mind Research, University Hospital of Psychiatry, Zurich, Switzerland
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Publication Date:
23 April 2007 (online)

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Abstract

Spontaneous multichannel brain electric field (EEG) map series of 20 seconds duration at 1, 15, 30, 45, and 60 minutes after the injection of a single dose of diazepam (13 ss) or sulpiride (6 ss) were segmented into microstates of quasi-constant landscape but varying durations. Post-minus-pre injection difference values were computed for the six microstate variables: specific window size, duration, orientation, distance between windows, and location of center of gravity on the anterior-posterior and left-right axis. Differences between drugs were explored with ANOVAs. Microstate duration increased after sulpiride, and the location of the microstate center of gravity on the anterior-posterior axis moved to a more anterior position after diazepam. The results are in agreement with expectations based on measurements of patients' EEC microstates and with results using estimates of EEC model source locations in the frequency domain. Microstate segmentation appears to be a useful method for physiologically meaningful reduction of multichannel brain electric field data in psychopharmacology.

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