Desacetylmatricarin, an Anti-Allergic Component from Taraxacum platycarpum

Cheong Ho; Eun Ju Choi; Gyurng Soo Yoo; Kyeong-Man Kim; Shi Yong Ryu

doi:10.1055/s-2006-957520

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000058.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Planta Med 1998; 64(6): 577-578
DOI: 10.1055/s-2006-957520

Letters

Desacetylmatricarin, an Anti-Allergic Component from Taraxacum platycarpum

Cheong Ho¹ , Eun Ju Choi² , Gyurng Soo Yoo¹ , Kyeong-Man Kim¹ , Shi Yong Ryu²

¹Pharmacology Laboratory, College of Pharmacy, Chonnam National University, Kwang-Ju, Korea
²Korea Research Institute of Chemical Technology, Yusung, Taejon, Korea

Further Information

Publication History

1997

1998

Publication Date:
01 February 2007 (online)

PDF Download Permissions and Reprints

Abstract

The bioassay-guided fractionation of Taraxacum platycarpum (Compositae) extract led to the isolation of a desacetylmatricarin (1) as an active principle responsible for the anti-allergic property. It showed a potent inhibitory activity upon the β-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC₅₀ was 7.5 µM. Two structurally related guaianolide sesquiterpenes, achillin and leucodin, were also examined and their IC₅₀ values were determined as 100 µM and 80 µM, respectively.

>