Benzodiazepine Binding Site-Interactive Flavones from Scutellaria baicalensis Roots

Jyh-Fei Liao; Hui-Hung Wang; Ming-Chih Chen; Chien-Chih Chen; Chieh-Fu Chen

doi:10.1055/s-2006-957517

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Planta Med 1998; 64(6): 571-572
DOI: 10.1055/s-2006-957517

Letters

Benzodiazepine Binding Site-Interactive Flavones from Scutellaria baicalensis Roots

Jyh-Fei Liao¹ , Hui-Hung Wang¹ , Ming-Chih Chen² , Chien-Chih Chen² , Chieh-Fu Chen²

¹Department and Institute of Pharmacology, National Yang-Ming University, Peitou, Taipei, Taiwan, Republic of China
²National Research Institute of Chinese Medicine, Peitou, Taipei, Taiwan, Republic of China

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Publication History

1997

1998

Publication Date:
01 February 2007 (online)

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Abstract

A benzodiazepine binding assay directed separation led to the identification of 3 flavones baicalein (1), oroxylin A (2), and skullcapflavone II (3) from the water extract of Scutellaria baicalensis root. Compounds 1, 2, and 3 interacted with the benzodiazepine binding site of GABA_A receptors with a K_i value of 13.1, 14.6 and 0.36 µmol/L, respectively.

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