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Horm Metab Res 2005; 37(4): 226-230
DOI: 10.1055/s-2005-861382
Original Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Effect of Hormone Replacement Therapy on the Production of Bone-resorbing Cytokines by Peripheral Blood Cells in Postmenopausal Women

H.  Uemura1 , M.  Kamada1 , M.  Maegawa1 , Y.  Ohmoto2 , K.  Murata2 , A.  Kuwahara1 , T.  Matsuzaki1 , T.  Yasui1 , T.  Takeji1 , M.  Irahara1
  • 1 Department of Obstetrics and Gynecology, School of Medicine, University of Tokushima, Tokushima
  • 2 Cellular Technology Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan
Further Information

Publication History

Received 11 May 2004

Accepted after revision 16 September 2004

Publication Date:
13 June 2005 (online)

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Abstract

We studied the effects of hormone replacement therapy (HRT) with estrogen on postmenopausal changes in the production of bone-resorbing cytokines interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNFα). Both cytokines were measured in the supernatants of lipopolysaccharide (LPS)-stimulated whole-blood cells from 72 untreated and 44 HRT-treated women by ELISA. The levels of IL-1β were significantly higher in women in their 40 s and 50 s and in postmenopausal women than in women in their teens, 20 s and 30 s, while the levels of TNFα did not show any changes related to age. Both levels in HRT-treated women were significantly lower than those in untreated women at almost every postmenopausal stage. In a prospective study, HRT induced significant declines in both levels. These results show that estrogen decreases the accelerated production of IL-1β and reduces the production of TNFα in postmenopausal women at each postmenopausal stage, even in late-postmenopausal women.

Key words

HRT - Postmenopause - IL-1β - TNFα - Whole-blood cells

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Hirokazu Uemura, M.D., PhD

Department of Obstetrics and Gynecology · University of Tokushima · School of Medicine

3-18-15 Kuramoto-cho · Tokushima · 770-8503 Japan

Phone: +81 (88) 633 71 77 ·

Fax: +81 (88) 631 26 30

Email: uemura@clin.med.tokushima-u.ac.jp

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