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Psychiatr Prax 2005; 32(4): 167-171
DOI: 10.1055/s-2004-828330
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Blutbildveränderungen unter Antipsychotika der zweiten Generation

Haematological Abnormalities during Treatment with Atypical AntipsychoticsJohannes  Thome1 , Daniel  Kopf2
  • 1Department of Psychiatry, School of Medicine, University of Wales Swansea
  • 2Zentralinstitut für Seelische Gesundheit, Mannheim
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Publication History

Publication Date:
25 April 2005 (online)

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Zusammenfassung

Die Gefahr schwerer Blutbildveränderungen stellt einen limitierenden Faktor in der Behandlung mit Clozapin dar. Durch die Entwicklung moderner Antipsychotika der zweiten Generation ist es heute aber möglich, die positiven Effekte dieser Medikamentengruppe zu nutzen, ohne die Risiken einer Clozapin-Behandlung eingehen zu müssen. Allerdings existiert eine Reihe von Kasuistiken, die zeigen, dass auch unter einer Behandlung mit Antipsychotika der zweiten Generation schwere Blutbildveränderungen auftreten können. Die vorliegende Arbeit gibt eine Übersicht über die bisher publizierten Fallberichte und diskutiert die Konsequenzen für die tägliche klinische Praxis.

Abstract

The danger of severe haematological abnormalities limits the use of clozapine in the treatment of psychoses. The development of modern second generation antipsychotics such as olanzapine, risperidone, quetiapine, amisulpride, ziprasidone or aripiprazol, however, makes it possible to use the positive effects of this class of drugs without the risks of a clozapine treatment. Nevertheless, there are several case reports about severe haematological abnormalities even during treatment with these second generation antipsychotics. This review summarises recently published cases and discusses the consequences for the daily clinical work.

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Prof. Dr. med. Dr. phil. Johannes Thome

Department of Psychiatry · School of Medicine · University of Wales Swansea

Grove Building

Singleton Park

Swansea, SA2 8PP

United Kingdom

Email: j.thome@swan.ac.uk

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