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Horm Metab Res 2003; 35(4): 259-264
DOI: 10.1055/s-2003-39483
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Effect of Parathyroidectomy on Bone Mineral Density in Hemodialysis Patients with Secondary Hyperparathyroidism: Possible Usefulness of Preoperative Determination of Parathyroid Hormone Level for Prediction of Bone Regain

S.  Yano 1, 2 , T.  Sugimoto 1 , T.  Tsukamoto 1 , T.  Yamaguchi 1 , T.  Hattori 3 , K.-I.  Sekita 3 , H.  Kaji 1, 3 , S.  Hattori 3 , A.  Kobayashi 4 , K.  Chihara 1
  • 1 Division of Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan
  • 2 Endocrine-Hypertension Division, Brigham and Women's Hospital, Boston, Massachusetts, USA
  • 3 Hattori Hospital, Miki, Japan
  • 4 Kobayashi Clinic, Kobe, Japan
Further Information

Publication History

Received 12 February 2002

Accepted after Revision 3 September 2002

Publication Date:
02 June 2003 (online)

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Abstract

Purpose: To examine longitudinal changes of bone mineral density (BMD) after parathyroidectomy (PTx) in patients undergoing maintenance hemodialysis (HD) with severe secondary hyperparathyroidism (HPT) to determine which factor contributes most to bone changes. Methods: Fifteen Japanese HD patients who had been refractory to medical therapy were subject to PTx with autotransplantation. We measured BMD by dual energy X-ray absorptiometry (DXA) at the lumbar spine (L2 - 4 BMD) and the distal 1/3 region of the radius (1/3R BMD) at 1, 3, 6, 12, 24, and 36 months after PTx. Results: Baseline Z-score of BMD was markedly low at 1/3R (- 3.07) and slightly low at L2 - 4 (-0.59) in this group. A significant increase in L2 - 4 BMD was observed as early as one month after PTx, which was sustained afterwards. Annual percent changes in L2 - 4 and 1/3R BMD were + 15.6 % and + 6.4 %, respectively. The annual percent changes in BMD at both sites were positively associated with preoperative intact PTH levels (L2 - 4; r = 0.642, p = 0.010, 1/3R; r = 0.884, p < 0.001) and total alkaline phosphatase (ALP) levels (L2 - 4; r = 0.663, p = 0.007, 1/3R; r = 0.858, p < 0.001). Stepwise multiple regression analysis revealed that serum levels of intact PTH and ALP were the best predictors of both percentage and net changes in radial BMD with high determination coefficients (r2 > 0.8). Conclusion: Successful PTx following appropriate supplementation with vitamin D and calcium provides a marked increase in lumbar BMD and a modest increase in radial BMD in HD patients with secondary HPT. Preoperative levels of PTH and ALP are useful for predicting postoperative changes in bone mass.

Key words

Bone mineral density - Parathyroid hormone - Parathyroidectomy - Hyperparathyroidism - Dialysis

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S. Yano, M.D. & Ph. D.

Endocrine-Hypertension Division · Brigham and Women's Hospital

221 Longwood Avenue · Boston · MA 02115 · USA ·

Phone: +1(617)2780764

Fax: +1(617)732-5764

Email: syano@rics.bwh.harvard.edu

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