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Aktuelle Ernährungsmedizin 2003; 28: 69-86
DOI: 10.1055/s-2003-36632
Gastroenterologie
© Georg Thieme Verlag Stuttgart · New York

DGEM-Leitlinie Enterale Ernährung:
Gastroenterologie

DGEM Guidelines Enteral Nutrition: GastroenterologyH.  Lübke1 , R.  Meier2 , H.  Lochs3 , S.  Bischoff4 , N.  Engelmann5 , P.  Thul6 , C.  Löser7 , V.  Keim8
  • 1Gastroenterologie und Hepatologie, Innere Abteilung, Zentralklinikum Emil von Behring, Department Behring Krankenhaus, Berlin
  • 2Abteilung Gastroenterologie, Hepatologie und Ernährung der med. Universitätsklinik am Kantonsspital Liestal
  • 3Medizinische Klinik, Gastroenterologie, Hepatologie und Endokrinologie, Universitätsklinikum Charité, Berlin
  • 4Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
  • 5Patientenvertreter Deutsche Morbus Crohn/Colitis ulcerosa Vereinigung DCCV e. V.
  • 6Klinik für Allgemein-, Viszeral-, Gefäß- und Thoraxchirurgie, Allgemeinchirurgische Poliklinik, Universitätsklinikum Charité, Berlin
  • 7Medizinische Klinik, Rotes-Kreuz-Krankenhaus Kassel
  • 8Med. Klinik und Poliklinik II, Universität Leipzig
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Publication History

Publication Date:
27 January 2003 (online)

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Morbus Crohn

Literatur

  • 1 Motil K J, Grand R J, Maletskos C J, Young V R. The effect of disease, drug, and diet on whole body protein metabolism in adolescents with Crohn disease and growth failure.  J Pediatr. 1982;  101 345-351
    PubMedGoogle Scholar
  • 2 Rosenberg I H, Bengoa J M, Sitrin M D. Nutritional aspects of inflammatory bowel disease.  Annu Rev Nutr. 1985;  5 463-484
    PubMedGoogle Scholar
  • 3 Heatley R V. Assessing nutritional state in inflammatory bowel disease.  Gut. 1986;  27, Suppl 1 61-66
    CrossrefPubMedGoogle Scholar
  • 4 Beeken W L, Busch H J, Sylwester D L. Intestinal protein loss in Crohn's disease.  Gastroenterology. 1972;  62 207-215
    PubMedGoogle Scholar
  • 5 Kanof M E, Lake A M, Bayless T M. Decreased height velocity in children and adolescents before the diagnosis of Crohn's disease.  Gastroenterology. 1988;  95 1523-1527
    PubMedGoogle Scholar
  • 6 Seidman E G. Nutritional management of inflammatory bowel disease.  Gastroenterol Clin North Am. 1989;  18 129-155
    PubMedGoogle Scholar
  • 7 Seidman E, LeLeiko N, Ament M. et al . Nutritional issues in pediatric inflammatory bowel disease.  J Pediatr Gastroenterol Nutr. 1991;  12 424-438
    PubMedGoogle Scholar
  • 8 Belli D C, Seidman E, Bouthillier L. et al . Chronic intermittent elemental diet improves growth failure in children with Crohn's disease.  Gastroenterology. 1988;  94 603-610
    PubMedGoogle Scholar
  • 9 Markowitz J, Grancher K, Rosa J, Aiges H, Daum F. Growth failure in pediatric inflammatory bowel disease.  J Pediatr Gastroenterol Nutr. 1993;  16 373-380
    CrossrefPubMedGoogle Scholar
  • 10 Kirschner B S. Growth and development in chronic inflammatory bowel disease.  Acta Paediatr Scand. 1990;  366, Suppl 98-104
    PubMedGoogle Scholar
  • 11 Hildebrand H, Karlberg J, Kristiansson B. Longitudinal growth in children and adolescents with inflammatory bowel disease.  J Pediatr Gastroenterol Nutr. 1994;  18 165-173
    PubMedGoogle Scholar
  • 12 Lashner B A. Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis.  J Cancer Res Clin Oncol. 1993;  119 549-554
    CrossrefPubMedGoogle Scholar
  • 13 Aiges H, Markowitz J, Rosa J, Daum F. Home nocturnal supplemental nasogastric feedings in growth-retarded adolescents with Crohn's disease.  Gastroenterology. 1989;  97 905-910
    PubMedGoogle Scholar
  • 14 Chan A T, Fleming C R, O'Fallon W M, Huizenga K A. Estimated versus measured basal energy requirements in patients with Crohn's disease.  Gastroenterology. 1986;  91 75-78
    PubMedGoogle Scholar
  • 15 Sjogren A, Floren C H, Nilsson A. Evaluation of magnesium status in Crohn's disease as assessed by intracellular analysis and intravenous magnesium infusion.  Scand J Gastroenterol. 1988;  23 555-561
    PubMedGoogle Scholar
  • 16 Geerling B J, Badart-Smook A, Stockbrugger R W, Brummer R J. Comprehensive nutritional status in patients with long-standing Crohn disease currently in remission.  Am J Clin Nutr. 1998;  67 919-926
    PubMedGoogle Scholar
  • 17 Rath H C, Caesar I, Roth M, Scholmerich J. Nutritional deficiencies and complications in chronic inflammatory bowel diseases.  Med Klin. 1998;  93 6-10
    PubMedGoogle Scholar
  • 18 Maier-Dobersberger T, Lochs H. Enteral supplementation of phosphate does not prevent hypophosphatemia during refeeding of cachectic patients.  JPEN J Parenter Enteral Nutr. 1994;  18 182-184
    PubMedGoogle Scholar
  • 19 Vogelsang H, Schofl R, Tillinger W, Ferenci P, Gangl A. 25-hydroxyvitamin D absorption in patients with Crohn's disease and with pancreatic insufficiency.  Wien Klin Wochenschr. 1997;  109 678-682
    PubMedGoogle Scholar
  • 20 Schoon E J, Muller M C, Vermeer C, Schurgers L J, Brummer R J, Stockbrugger R W. Low serum and bone vitamin K status in patients with longstanding Crohn's disease: another pathogenetic factor of osteoporosis in Crohn's disease?.  Gut. 2001;  48 473-477
    CrossrefPubMedGoogle Scholar
  • 21 Saitoh O, Matsumoto H, Sugimori K. et al . Intestinal protein loss and bleeding assessed by fecal hemoglobin, transferrin, albumin, and alpha-1-antitrypsin levels in patients with colorectal diseases.  Digestion. 1995;  56 67-75
    PubMedGoogle Scholar
  • 22 Becker K, Niederau C, Frieling T. Fecal excretion of alpha 2-macroglobulin: a novel marker for disease activity in patients with inflammatory bowel disease.  Z Gastroenterol. 1999;  37 597-605
    PubMedGoogle Scholar
  • 23 Hundegger K, Stufler M, Karbach U. Enteric protein loss as a marker of intestinal inflammatory activity in Crohn's disease: comparability of enteric clearance and stool concentration of alpha-1-antitrypsin?.  Z Gastroenterol. 1992;  30 722-728
    PubMedGoogle Scholar
  • 24 Mingrone G, Benedetti G, Capristo E. et al . Twenty-four-hour energy balance in Crohn disease patients: metabolic implications of steroid treatment.  Am J Clin Nutr. 1998;  67 118-123
    PubMedGoogle Scholar
  • 25 Stokes M A, Hill G L. Total energy expenditure in patients with Crohn's disease: measurement by the combined body scan technique.  JPEN J Parenter Enteral Nutr. 1993;  17 3-7
    PubMedGoogle Scholar
  • 26 O'Morain C, Segal A M, Levi A J, Valman H B. Elemental diet in acute Crohn's disease.  Arch Dis Child. 1983;  58 44-47
    PubMedGoogle Scholar
  • 27 Azcue M, Rashid M, Griffiths A, Pencharz P B. Energy expenditure and body composition in children with Crohn's disease: effect of enteral nutrition and treatment with prednisolone.  Gut. 1997;  41 203-208
    PubMedGoogle Scholar
  • 28 Rigaud D, Cerf M, Angel A L, Sobhani I, Carduner M J, Mignon M. Increase of resting energy expenditure during flare-ups in Crohn disease.  Gastroenterol Clin Biol. 1993;  17 932-937
    PubMedGoogle Scholar
  • 29 Schneeweiss B, Lochs H, Zauner C. et al . Energy and substrate metabolism in patients with active Crohn's disease.  J Nutr. 1999;  129 844-848
    PubMedGoogle Scholar
  • 30 Muller M J, Schmidt L U, Korber J, von zur M A, Canzler H, Schmidt F W. Reduced metabolic efficiency in patients with Crohn's disease.  Dig Dis Sci. 1993;  38 2001-2009
    CrossrefPubMedGoogle Scholar
  • 31 Barot L R, Rombeau J L, Feurer I D, Mullen J L. Caloric requirements in patients with inflammatory bowel disease.  Ann Surg. 1982;  195 214-218
    PubMedGoogle Scholar
  • 32 Geerling B J, Badart-Smook A, Stockbrugger R W, Brummer R J. Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls.  Eur J Clin Nutr. 2000;  54 514-521
    CrossrefPubMedGoogle Scholar
  • 33 Semeao E J, Jawad A F, Stouffer N O, Zemel B S, Piccoli D A, Stallings V A. Risk factors for low bone mineral density in children and young adults with Crohn's disease.  J Pediatr. 1999;  135 593-600
    PubMedGoogle Scholar
  • 34 Issenman R M. Bone mineral metabolism in pediatric inflammatory bowel disease.  Inflamm Bowel Dis. 1999;  5 192-199
    PubMedGoogle Scholar
  • 35 Capristo E, De Gaetano A, Mingrone G. et al . Multivariate identification of metabolic features in inflammatory bowel disease.  Metabolism. 1999;  48 952-956
    CrossrefPubMedGoogle Scholar
  • 36 Harries A D, Brown R, Heatley R V, Williams L A, Woodhead S, Rhodes J. Vitamin D status in Crohn's disease: association with nutrition and disease activity.  Gut. 1985;  26 1197-1203
    PubMedGoogle Scholar
  • 37 Haugeberg G, Vetvik K, Stallemo A, Bitter H, Mikkelsen B, Stokkeland M. Bone density reduction in patients with Crohn disease and associations with demographic and disease variables: cross-sectional data from a population-based study.  Scand J Gastroenterol. 2001;  36 759-765
    PubMedGoogle Scholar
  • 38 Bernstein C N, Seeger L L, Sayre J W, Anton P A, Artinian L, Shanahan F. Decreased bone density in inflammatory bowel disease is related to corticosteroid use and not disease diagnosis.  J Bone Miner Res. 1995;  10 250-256
    PubMedGoogle Scholar
  • 39 Stockbrugger R W, Schoon E J, Bollani S. et al . Discordance between the degree of osteopenia and the prevalence of spontaneous vertebral fractures in Crohn's disease.  Aliment Pharmacol Ther. 2002;  16 1519-1527
    CrossrefPubMedGoogle Scholar
  • 40 Klaus J, Armbrecht G, Steinkamp M. et al . High prevalence of osteoporotic vertebral fractures in patients with Crohn's disease.  Gut. 2002;  51 654-658
    CrossrefPubMedGoogle Scholar
  • 41 Habtezion A, Silverberg M S, Parkes R, Mikolainis S, Steinhart A H. Risk factors for low bone density in Crohn's disease.  Inflamm Bowel Dis. 2002;  8 87-92
    PubMedGoogle Scholar
  • 42 Bernstein C N, Blanchard J F, Leslie W, Wajda A, Yu B N. The incidence of fracture among patients with inflammatory bowel disease. A population-based cohort study.  Ann Intern Med. 2000;  133 795-799
    CrossrefPubMedGoogle Scholar
  • 43 Cucino C, Sonnenberg A. Cause of death in patients with inflammatory bowel disease.  Inflamm Bowel Dis. 2001;  7 250-255
    CrossrefPubMedGoogle Scholar
  • 44 Lindor K D, Fleming C R, Ilstrup D M. Preoperative nutritional status and other factors that influence surgical outcome in patients with Crohn's disease.  Mayo Clin Proc. 1985;  60 393-396
    CrossrefPubMedGoogle Scholar
  • 45 Higgens C S, Keighley M R, Allan R N. Impact of preoperative weight loss and body composition changes on postoperative outcome in surgery for inflammatory bowel disease.  Gut. 1984;  25 732-736
    CrossrefPubMedGoogle Scholar
  • 46 Motil K J, Grand R J, Davis-Kraft L, Ferlic L L, Smith E O. Growth failure in children with inflammatory bowel disease: a prospective study.  Gastroenterology. 1993;  105 681-691
    PubMedGoogle Scholar
  • 47 Messori A, Trallori G, D'Albasio G, Milla M, Vannozzi G, Pacini F. Defined-formula diets versus steroids in the treatment of active Crohn's disease: a meta-analysis.  Scand J Gastroenterol. 1996;  31 267-272
    PubMedGoogle Scholar
  • 48 Griffiths A M, Ohlsson A, Sherman P M, Sutherland L R. Meta-analysis of enteral nutrition as a primary treatment of active Crohn's disease.  Gastroenterology. 1995;  108 1056-1067
    CrossrefPubMedGoogle Scholar
  • 49 Zachos M, Tondeur M, Griffiths A M. Enteral nutritional therapy for inducing remission of Crohn's disease. Cochrane Database Syst Rev 2001 3 CD 000542
    Google Scholar
  • 50 O'Morain C, Segal A W, Levi A J. Elemental diet as primary treatment of acute Crohn's disease: a controlled trial.  Br Med J (Clin Res Ed). 1984;  288 1859-1862
    PubMedGoogle Scholar
  • 51 Gorard D A, Hunt J B, Payne-James J J. et al . Initial response and subsequent course of Crohn's disease treated with elemental diet or prednisolone.  Gut. 1993;  34 1198-1202
    PubMedGoogle Scholar
  • 52 Lindor K D, Fleming C R, Burnes J U, Nelson J K, Ilstrup D M. A randomized prospective trial comparing a defined formula diet, corticosteroids, and a defined formula diet plus corticosteroids in active Crohn's disease.  Mayo Clin Proc. 1992;  67 328-333
    PubMedGoogle Scholar
  • 53 Gonzalez-Huix F, de Leon R, Fernandez-Banares F. et al . Polymeric enteral diets as primary treatment of active Crohn's disease: a prospective steroid controlled trial.  Gut. 1993;  34 778-782
    PubMedGoogle Scholar
  • 54 Malchow H, Steinhardt H J, Lorenz-Meyer H. et al . Feasibility and effectiveness of a defined-formula diet regimen in treating active Crohn's disease. European Cooperative Crohn's Disease Study III.  Scand J Gastroenterol. 1990;  25 235-244
    PubMedGoogle Scholar
  • 55 Lochs H, Steinhardt H J, Klaus-Wentz B. et al . Comparison of enteral nutrition and drug treatment in active Crohn's disease. Results of the European Cooperative Crohn's Disease Study. IV.  Gastroenterology. 1991;  101 881-888
    PubMedGoogle Scholar
  • 56 Seidman E, Griffiths A, Jones A, Issenman R. Semielemental diet versus prednisone in the treatment of active Crohns's disease in children and adolescents.  Gastroenterology. 1993;  104 A778 (Abstract)
    PubMedGoogle Scholar
  • 57 Le Quintrec Y, Cosnes J, Le Quintrec M. et al . Exclusive elemental enteral diet in cortico-resistant and cortico-dependent forms of Crohn's disease.  Gastroenterol Clin Biol. 1987;  11 477-482
    PubMedGoogle Scholar
  • 58 Greenberg G R, Fleming C R, Jeejeebhoy K N, Rosenberg I H, Sales D, Tremaine W J. Controlled trial of bowel rest and nutritional support in the management of Crohn's disease.  Gut. 1988;  29 1309-1315
    CrossrefPubMedGoogle Scholar
  • 59 Lochs H, Egger-Schödl M, Pötzi R, Kappel C H, Schuh R. Enterale Ernährung - eine Alternative zur parenteralen Ernährung in der Behandlung von Morbus Crohn?.  Leber, Magen, Darm. 1984;  14 64-67
    PubMedGoogle Scholar
  • 60 Lochs H, Meryn S, Marosi L, Ferenci P, Hörtnagl H. Has total bowel rest a beneficial effect in the treatment of Crohn's Disease?.  Clin Nutr. 1983;  2 61-64
    PubMedGoogle Scholar
  • 61 Wright R A, Adler E C. Peripheral parenteral nutrition is no better than enteral nutrition in acute exacerbation of Crohn's disease: a prospective trial.  J Clin Gastroenterol. 1990;  12 396-399
    PubMedGoogle Scholar
  • 62 Verma S, Kirkwood B, Brown S, Giaffer M H. Oral nutritional supplementation is effective in the maintenance of remission in Crohn's disease.  Dig Liver Dis. 2000;  32 769-774
    CrossrefPubMedGoogle Scholar
  • 63 Wilschanski M, Sherman P, Pencharz P, Davis L, Corey M, Griffiths A. Supplementary enteral nutrition maintains remission in paediatric Crohn's disease.  Gut. 1996;  38 543-548
    CrossrefPubMedGoogle Scholar
  • 64 Hirakawa H, Fukuda Y, Tanida N, Hosomi M, Shimoyama T. Home elemental enteral hyperalimentation (HEEH) for the maintenance of remission in patients with Crohn's disease.  Gastroenterol Jpn. 1993;  28 379-384
    PubMedGoogle Scholar
  • 65 Royall D, Jeejeebhoy K N, Baker J P. et al . Comparison of amino acid v peptide based enteral diets in active Crohn's disease: clinical and nutritional outcome.  Gut. 1994;  35 783-787
    PubMedGoogle Scholar
  • 66 Harries A D, Jones L A, Danis V. et al . Controlled trial of supplemented oral nutrition in Crohn's disease.  Lancet. 1983;  1 887-890
    PubMedGoogle Scholar
  • 67 Blondel-Kucharski F, Chircop C, Marquis P. et al . Health-related quality of life in Crohn's disease: a prospective longitudinal study in 231 patients.  Am J Gastroenterol. 2001;  96 2915-2920
    CrossrefPubMedGoogle Scholar
  • 68 Malone M. Quality of life of patients receiving home parenteral or enteral nutrition support.  Pharmacoeconomics. 1994;  5 101-108
    PubMedGoogle Scholar
  • 69 Rees R G, Keohane P P, Grimble G K, Frost P G, Attrill H, Silk D B. Elemental diet administered nasogastrically without starter regimens to patients with inflammatory bowel disease.  JPEN J Parenter Enteral Nutr. 1986;  10 258-262
    PubMedGoogle Scholar
  • 70 Mahajan L, Oliva L, Wyllie R, Fazio V, Steffen R, Kay M. The safety of gastrostomy in patients with Crohn's disease.  Am J Gastroenterol. 1997;  92 985-988
    PubMedGoogle Scholar
  • 71 Cosgrove M, Jenkins H R. Experience of percutaneous endoscopic gastrostomy in children with Crohn's disease.  Arch Dis Child. 1997;  76 141-143
    PubMedGoogle Scholar
  • 72 Anstee Q M, Forbes A. The safe use of percutaneous gastrostomy for enteral nutrition in patients with Crohn's disease.  Eur J Gastroenterol Hepatol. 2000;  12 1089-1093
    CrossrefPubMedGoogle Scholar
  • 73 Verma S, Brown S, Kirkwood B, Giaffer M H. Polymeric versus elemental diet as primary treatment in active Crohn's disease: a randomized, double-blind trial.  Am J Gastroenterol. 2000;  95 735-739
    CrossrefPubMedGoogle Scholar
  • 74 Mansfield J C, Giaffer M H, Holdsworth C D. Controlled trial of oligopeptide versus amino acid diet in treatment of active Crohn's disease.  Gut. 1995;  36 60-66
    PubMedGoogle Scholar
  • 75 Park H R, Galloway A, Danesh J ZD, Russell R. Double-blind controlled trial of elemental and polymeric diets as primary therapy in actice Crohn's disease.  Eur J Gastroenterol Hepatol. 1991;  3 483-490
    PubMedGoogle Scholar
  • 76 Middleton S J, Riordan A M, Hunter . Comparison of elemental and peptide-based diets in the treatment of acute Crohn's disease.  Ital J Gastroenterol. 1991;  23 609A
    PubMedGoogle Scholar
  • 77 Raouf A H, Hildrey V, Daniel J. et al . Enteral feeding as sole treatment for Crohn's disease: controlled trial of whole protein v amino acid based feed and a case study of dietary challenge.  Gut. 1991;  32 702-707
    PubMedGoogle Scholar
  • 78 Rigaud D, Cosnes J, Le Quintrec Y, Rene E, Gendre J P, Mignon M. Controlled trial comparing two types of enteral nutrition in treatment of active Crohn's disease: elemental versus polymeric diet.  Gut. 1991;  32 1492-1497
    PubMedGoogle Scholar
  • 79 Sakurai T, Matsui T, Yao T. et al . Short-term efficacy of enteral nutrition in the treatment of active Crohn's disease: a randomized, controlled trial comparing nutrient formulas.  JPEN J Parenter Enteral Nutr. 2002;  26 98-103
    CrossrefPubMedGoogle Scholar
  • 80 Khoshoo V, Reifen R, Neuman M G, Griffiths A, Pencharz P B. Effect of low- and high-fat, peptide-based diets on body composition and disease activity in adolescents with active Crohn's disease.  JPEN J Parenter Enteral Nutr. 1996;  20 401-405
    CrossrefPubMedGoogle Scholar
  • 81 Gassull M A, Fernandez-Banares F, Cabre E. et al . Fat composition may be a clue to explain the primary therapeutic effect of enteral nutrition in Crohn's disease: results of a double blind randomised multicentre European trial.  Gut. 2002;  51 164-168
    CrossrefPubMedGoogle Scholar
  • 82 Akobeng A K, Miller V, Stanton J, Elbadri A M, Thomas A G. Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn's disease.  J Pediatr Gastroenterol Nutr. 2000;  30 78-84
    CrossrefPubMedGoogle Scholar
  • 83 Den Hond E, Hiele M, Peeters M, Ghoos Y, Rutgeerts P. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease.  JPEN J Parenter Enteral Nutr. 1999;  23 7-11
    CrossrefPubMedGoogle Scholar
  • 84 Beattie R M, Schiffrin E J, Donnet-Hughes A. et al . Polymeric nutrition as the primary therapy in children with small bowel Crohn's disease.  Aliment Pharmacol Ther. 1994;  8 609-615
    PubMedGoogle Scholar
  • 85 Fell J M, Paintin M, Arnaud-Battandier F. et al . Mucosal healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn's disease.  Aliment Pharmacol Ther. 2000;  14 281-289
    CrossrefPubMedGoogle Scholar
  • 86 Capristo E, Mingrone G, Addolorato G, Greco A V, Gasbarrini G. Metabolic features of inflammatory bowel disease in a remission phase of the disease activity.  J Intern Med. 1998;  243 339-347
    CrossrefPubMedGoogle Scholar
  • 87 Klein S, Meyer S, O'Sullivan P. The metabolic impact of active ulcerative colitis. Energy expenditure and nitrogen balance.  J Clin Gastroenterol. 1988;  10 34-40
    PubMedGoogle Scholar
  • 88 Schreiber J, Shurin S B. Oral care with vancomycin paste for alpha-hemolytic streptococcal sepsis.  J Pediatr Hematol Oncol. 1996;  18 334
    CrossrefPubMedGoogle Scholar
  • 89 Rath H C, Caesar I, Roth M, Scholmerich J. Nutritional deficiencies and complications in chronic inflammatory bowel diseases.  Med Klin. 1998;  93 6-10
    PubMedGoogle Scholar
  • 90 Franklin J L, Rosenberg H H. Impaired folic acid absorption in inflammatory bowel disease: effects of salicylazosulfapyridine (Azulfidine).  Gastroenterology. 1973;  64 517-525
    PubMedGoogle Scholar
  • 91 Lashner B A. Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis.  J Cancer Res Clin Oncol. 1993;  119 549-554
    CrossrefPubMedGoogle Scholar
  • 92 Boot A M, Bouquet J, Krenning E P, de Muinck Keizer-Schrama S M. Bone mineral density and nutritional status in children with chronic inflammatory bowel disease.  Gut. 1998;  42 188-194
    CrossrefPubMedGoogle Scholar
  • 93 Jahnsen J, Falch J A, Aadland E, Mowinckel P. Bone mineral density is reduced in patients with Crohn's disease but not in patients with ulcerative colitis: a population based study.  Gut. 1997;  40 313-319
    CrossrefPubMedGoogle Scholar
  • 94 Brandes J W, Stenner A, Martini G A. Dietary habits of patients with ulcerative colitis.  Z Gastroenterol. 1997;  17 834-842
    PubMedGoogle Scholar
  • 95 Jones L A, Harries A D, Rhodes J, Heatley R V. Normal energy intake in undernourished patients with Crohn's disease.  Br Med J (Clin Res Ed). 1984;  288 193
    PubMedGoogle Scholar
  • 96 Tragnone A, Valpiani D, Miglio F. et al . Dietary habits as risk factors for inflammatory bowel disease.  Eur J Gastroenterol Hepatol. 1995;  7 47-51
    PubMedGoogle Scholar
  • 97 Rocchio M A, Cha C J, Haas K F, Randall H T. Use of chemically defined diets in the management of patients with acute inflammatory bowel disease.  Am J Surg. 1974;  127 469-475
    CrossrefPubMedGoogle Scholar
  • 98 Axelsson C, Jarnum S. Assessment of the therapeutic value of an elemental diet in chronic inflammatory bowel disease.  Scand J Gastroenterol. 1977;  12 89-95
    PubMedGoogle Scholar
  • 99 McIntyre P B, Powell-Tuck J, Wood S R. et al . Controlled trial of bowel rest in the treatment of severe acute colitis.  Gut. 1986;  27 481-485
    PubMedGoogle Scholar
  • 100 Gonzalez-Huix F, Fernandez-Banares F, Esteve-Comas M. et al . Enteral versus parenteral nutrition as adjunct therapy in acute ulcerative colitis.  Am J Gastroenterol. 1993;  88 227-232
    PubMedGoogle Scholar
  • 101 Stenson W F, Cort D, Rodgers J. et al . Dietary supplementation with fish oil in ulcerative colitis.  Ann Intern Med. 1992;  116 609-614
    PubMedGoogle Scholar
  • 102 Hawthorne A B, Daneshmend T K, Hawkey C J. et al . Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial.  Gut. 1992;  33 922-928
    CrossrefPubMedGoogle Scholar
  • 103 Loeschke K, Ueberschaer B, Pietsch A. et al . N-3 fatty acids only delay early relapse of ulcerative colitis in remission.  Dig Dis Sci. 1996;  41 2087-2094
    PubMedGoogle Scholar
  • 104 Purdum P P, Kirby D F. Short-bowel syndrome: a review of the role of nutrition support.  JPEN J Parenter Enteral Nutr. 1991;  15 93-101
    PubMedGoogle Scholar
  • 105 Marotta R, Floch M H. Dietary therapy of steatorhoea.  Gastroenterol Clin North Am. 1993;  18 485-508
    PubMedGoogle Scholar
  • 106 Nightingale J M, Lennard-Jones J E. The short bowel syndrome: what's new and old?.  Dig Dis. 1993;  11 12-31
    PubMedGoogle Scholar
  • 107 Messing B, Pigot F, Rongier M, Morin M C, Ndeindoum U, Rambaud J C. Intestinal absorption of free oral hyperalimentation in the very short bowel syndrome.  Gastroenterology. 1991;  100 1502-1508
    PubMedGoogle Scholar
  • 108 Jeppesen P B, Mortensen P B. Intestinal failure defined by measurements of intestinal energy and wet weight absorption.  Gut. 2000;  46 701-706
    Google Scholar
  • 109 Woolf G M, Miller C, Kurian R, Jeejeebhoy K N. Nutritional absorption in short bowel syndrome. Evaluation of fluid, calorie, and divalent cation requirements.  Dig Dis Sci. 1987;  32 8-15
    CrossrefPubMedGoogle Scholar
  • 110 Nordgaard I, Hansen B S, Mortensen P B. Colon as a digestive organ in patient with short bowel.  Lancet. 1994;  343 373-376
    CrossrefPubMedGoogle Scholar
  • 111 Ovensen L, Chu R, Howard L. The influence of dietary fat on jejunostomy output in patients with severe short bowel syndrome.  Am J Clin Nutr. 1983;  38 270-278
    PubMedGoogle Scholar
  • 112 Cosnes J, Gendre J P, Evard D, Le Quintrec Y. Compensatory enteral hyperalimentation for management of patients with severe short bowel syndrome.  Am J Clin Nutr. 1985;  41 1002-1009
    PubMedGoogle Scholar
  • 113 Booth I W. Enteral nutrition as primary therapy in short bowel syndrome.  Gut. 1994;  35 S69-S72
    PubMedGoogle Scholar
  • 114 Carbonnel F, Cosnes J, Chevret S. et al . The role of anatomic factors in nutritional autonomy after extensive small bowel resection.  JPEN J Parenter Enteral Nutr. 1996;  20 275-280
    CrossrefPubMedGoogle Scholar
  • 115 Rabast U. Ernährungstherapie beim Kurzdarmsyndrom.  Akt Ernaehr Med. 1997;  22 103-111
    PubMedGoogle Scholar
  • 116 Rodriguez D J, Clevenger F W. Successful enteral refeeding after massive small bowel resection.  West J Med. 1993;  159 192-194
    PubMedGoogle Scholar
  • 117 Dudrick S J, Latifi R, Fosnocht D E. Management of the short-bowel syndrome.  Surg Clin North Am. 1991;  71 625-643
    PubMedGoogle Scholar
  • 118 Griffin G E, Fagan E F, Hodgson H J, Chadwick V S. Enteral therapy in the management of massive gut resection complicated by chronic fluid and electrolyte depletion.  Dig Dis Sci. 1982;  27 902-908
    CrossrefPubMedGoogle Scholar
  • 119 Lennard-Jones J E. Review article: practical management of the short bowel.  Aliment Pharmacol Ther. 1994;  8 563-577
    PubMedGoogle Scholar
  • 120 McIntyre P B, Fitchew M, Lennard-Jones J E. Patients with a high jejunostomy do not need a special diet.  Gastroenterology. 1986;  91 25-33
    PubMedGoogle Scholar
  • 121 Suchner U, Senftleben U, Eckart T. et al . Enteral versus parenteral nutrition: effects on gastrointestinal function and metabolism.  Nutrition. 1996;  12 13-22
    CrossrefPubMedGoogle Scholar
  • 122 Wicks C, Somasundaram S, Bjarnason I. et al . Comparison of enteral feeding and total parenteral nutrition after liver transplantation.  Lancet. 1994;  344 837-840
    CrossrefPubMedGoogle Scholar
  • 123 Hadfield R J, Sinclair D G, Houldsworth P E, Evans T W. Effects of enteral and parenteral nutrition on gut mucosal permeability in the critically ill.  Am J Respir Crit Care Med. 1995;  152 1545-1548
    CrossrefPubMedGoogle Scholar
  • 124 Reynolds J V, Kanwar S, Welsh F K. et al . Does the route of feeding modify gut barrier function and clinical outcome in patients after major upper gastrointestinal surgery?.  JPEN J Parenter Enteral Nutr. 1997;  21 196-201
    CrossrefPubMedGoogle Scholar
  • 125 Hoensch H P, Steinhardt H J, Weiss G, Haug D, Maier A, Malchow H. Effects of semisynthetic diets on xenobiotic metabolizing enzyme activity and morphology of small intestinal mucosa in humans.  Gastroenterology. 1984;  86 1519-1530
    PubMedGoogle Scholar
  • 126 Lipman T O. Grains or veins: is enteral nutrition really better than parenteral nutrition? A look at the evidence.  JPEN J Parenter Enteral Nutr. 1998;  22 167-182
    PubMedGoogle Scholar
  • 127 Cosnes J, Carbonnel F. Oral and enteral nutrition management and drug treatment of short bowel syndrome.  Clin Nutr. 1995;  14 16-20
    PubMedGoogle Scholar
  • 128 Wilmore D W, Robinson M K. Short bowel syndrome.  World J Surg. 2000;  24 1486-1492
    CrossrefPubMedGoogle Scholar
  • 129 Byrne T A, Persinger R L, Young L S, Ziegler T R, Wilmore D W. A new treatment for patients with short-bowel syndrome. Growth hormone, glutamine, and a modified diet.  Ann Surg. 1995;  222 243-254
    CrossrefPubMedGoogle Scholar
  • 130 Scolapio J S, McGreevy K, Tennyson G S, Burnett O L. Effect of glutamine in short-bowel syndrome.  Clin Nutr. 2001;  20 319-323
    CrossrefPubMedGoogle Scholar
  • 131 Li L, Irving M. The effectiveness of growth hormone, glutamine and a low-fat diet containing high-carbohydrate on the enhancement of the function of remnant intestine among patients with short bowel syndrome: a review of published trials.  Clin Nutr. 2001;  20 199-204
    PubMedGoogle Scholar
  • 132 Shaw J H, Wolfe R R. Glucose, fatty acid, and urea kinetics in patients with severe pancreatitis. The response to substrate infusion and total parenteral nutrition.  Ann Surg. 1986;  204 665-672
    CrossrefPubMedGoogle Scholar
  • 133 Dickerson R N, Vehe K L, Mullen J L, Feurer I D. Resting energy expenditure in patients with pancreatitis 1.  Crit Care Med. 1991;  19 484-490
    CrossrefPubMedGoogle Scholar
  • 134 Bouffard Y H, Delafosse B X, Annat G J, Viale J P, Bertrand O M, Motin J P. Energy expenditure during severe acute pancreatitis 1.  JPEN J Parenter Enteral Nutr. 1989;  13 26-29
    PubMedGoogle Scholar
  • 135 Feller J H, Brown R A, Toussaint G P, Thompson A G. Changing methods in the treatment of severe pancreatitis 1.  Am J Surg. 1974;  127 196-201
    CrossrefPubMedGoogle Scholar
  • 136 Sitzmann J V, Steinborn P A, Zinner M J, Cameron J L. Total parenteral nutrition and alternate energy substrates in treatment of severe acute pancreatitis 1.  Surg Gynecol Obstet. 1989;  168 311-317
    PubMedGoogle Scholar
  • 137 Cameron J L, Capuzzi D M, Zuidema G D, Margolis S. Acute pancreatitis with hyperlipemia. Evidence for a persistent defect in lipid metabolism 1.  Am J Med. 1974;  56 482-487
    CrossrefPubMedGoogle Scholar
  • 138 Cameron J L, Capuzzi D M, Zuidema G D, Margolis S. Acute pancreatitis with hyperlipemia: the incidence of lipid abnormalities in acute pancreatitis 1.  Ann Surg. 1973;  177 483-489
    CrossrefPubMedGoogle Scholar
  • 139 Greenberger N J. Pancreatitis and hyperlipemia 1.  N Engl J Med. 1973;  289 586-587
    PubMedGoogle Scholar
  • 140 Robin A P, Campbell R, Palani C K, Liu K, Donahue P E, Nyhus L M. Total parenteral nutrition during acute pancreatitis: clinical experience with 156 patients 1.  World J Surg. 1990;  14 572-579
    CrossrefPubMedGoogle Scholar
  • 141 Sax H C, Warner B W, Talamini M A. et al . Early total parenteral nutrition in acute pancreatitis: lack of beneficial effects 1.  Am J Surg. 1987;  153 117-124
    CrossrefPubMedGoogle Scholar
  • 142 McClave S A, Greene L M, Snider H L. et al . Comparison of the safety of early enteral vs parenteral nutrition in mild acute pancreatitis 4.  JPEN J Parenter Enteral Nutr. 1997;  21 14-20
    CrossrefPubMedGoogle Scholar
  • 143 Windsor A C, Kanwar S, Li A G. et al . Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis 1.  Gut. 1998;  42 431-435
    CrossrefPubMedGoogle Scholar
  • 144 Powell J J, Murchison J T, Fearon K C, Ross J A, Siriwardena A K. Randomized controlled trial of the effect of early enteral nutrition on markers of the inflammatory response in predicted severe acute pancreatitis 1.  Br J Surg. 2000;  87 1375-1381
    CrossrefPubMedGoogle Scholar
  • 145 Kalfarentzos F, Kehagias J, Mead N, Kokkinis K, Gogos C A. Enteral nutrition is superior to parenteral nutrition in severe acute pancreatitis: results of a randomized prospective trial 1.  Br J Surg. 1997;  84 1665-1669
    CrossrefPubMedGoogle Scholar
  • 146 Cravo M, Camilo M E, Marques A, Pinto Correia J. Early tube feeding in acute pancreatitis: A prospective study.  Clin Nutr. 1989;  8, Suppl 1 7-14
    PubMedGoogle Scholar
  • 147 Kudsk K A, Campbell S M, O’Brien T, Fuller R. Postoperative jejunal feedings following complicated pancreatitis 1.  Nutr Clin Pract. 1990;  5 14-17
    PubMedGoogle Scholar
  • 148 Nakad A, Piessevaux H, Marot J C. et al . Is early enteral nutrition in acute pancreatitis dangerous? About 20 patients fed by an endoscopically placed nasogastrojejunal tube 1.  Pancreas. 1998;  17 187-193
    PubMedGoogle Scholar
  • 149 Stabile B E, Debas H T. Intravenous versus intraduodenal amino acids, fats, and glucose as stimulants of pancreatic section.  Surg Forum. 1981;  32 224-226
    PubMedGoogle Scholar
  • 150 Blackburn G L, Williams L F, Bistrian B R. et al . New approaches to the management of severe acute pancreatitis 4.  Am J Surg. 1976;  131 114-124
    CrossrefPubMedGoogle Scholar
  • 151 Grant J P, James S, Grabowski V, Trexler K M. Total parenteral nutrition in pancreatic disease 3.  Ann Surg. 1984;  200 627-631
    PubMedGoogle Scholar
  • 152 Simpson W G, Marsano L, Gates L. Enteral nutritional support in acute alcoholic pancreatitis 1.  J Am Coll Nutr. 1995;  14 662-665
    PubMedGoogle Scholar
  • 153 Levy P, Heresbach D, Pariente E A. et al . Frequency and risk factors of recurrent pain during refeeding in patients with acute pancreatitis: a multivariate multicentre prospective study of 116 patients 1.  Gut. 1997;  40 262-266
    CrossrefPubMedGoogle Scholar
  • 154 Neviackas J A, Kerstein M D. Pancreatic enzyme response with an elemental diet 1.  Surg Gynecol Obstet. 1976;  142 71-74
    PubMedGoogle Scholar
  • 155 McArdle A H, Echave W, Brown R A, Thompson A G. Effect of elemental diet on pancreatic secretion 1.  Am J Surg. 1974;  128 690-692
    PubMedGoogle Scholar
  • 156 Cassim M M, Allardyce D B. Pancreatic secretion in response to jejunal feeding of elemental diet.  Ann Surg. 1974;  180 228-231
    PubMedGoogle Scholar
  • 157 Grant J P, Davey-McCrae J, Snyder P J. Effect of enteral nutrition on human pancreatic secretions 2.  JPEN J Parenter Enteral Nutr. 1987;  11 302-304
    PubMedGoogle Scholar
  • 158 Vison N, Hecketsweiler P, Butel J, Bernier J J. Effect of continuous jejunal perfusion of elemental and complex nutritional solutions on pancreatic enzyme secretion in human subjects 1.  Gut. 1978;  19 194-198
    PubMedGoogle Scholar
  • 159 Ragins H, Levenson S M, Signer R, Stamford W, Seifter E. Intrajejunal administration of an elemental diet at neutral pH avoids pancreatic stimulation. Studies in dog and man 1.  Am J Surg. 1973;  126 606-614
    PubMedGoogle Scholar
  • 160 Trice S, Melnik G, Page C P. Complications and costs of early postoperative parenteral versus enteral nutrition in trauma patients.  Nutr Clin Pract. 1997;  12 114-119
    PubMedGoogle Scholar
  • 161 Heyland D K, Novak F, Drover J W, Jain M, Su X, Suchner U. Should immunonutrition become routine in critically ill patients? A systematic review of the evidence 1.  JAMA. 2001;  286 944-953
    CrossrefPubMedGoogle Scholar
  • 162 DiMagno E P, Go V L, Summerskill W H. Relations between pancreatic enzyme ouputs and malabsorption in severe pancreatic insufficiency 15.  N Engl J Med. 1973;  288 813-815
    PubMedGoogle Scholar
  • 163 DiMagno E P, Layer P. Human exocrine pankreatic enzyme secretion. In: Go VL (ed) The pancreas. Biology, pathobiology, and disease. New York; Raven Press 1993: 275-300
    Google Scholar
  • 164 Lanspa S J, Chan A T, Bell J S, Go V L, Dickson E R, DiMagno E P. Pathogenesis of steatorrhea in primary biliary cirrhosis 1.  Hepatology. 1985;  5 837-842
    PubMedGoogle Scholar
  • 165 Hebuterne X, Hastier P, Peroux J L, Zeboudj N, Delmont J P, Rampal P. Resting energy expenditure in patients with alcoholic chronic pancreatitis 1.  Dig Dis Sci. 1996;  41 533-539
    CrossrefPubMedGoogle Scholar
  • 166 DiMagno E P, Clain J E, Layer P. Chronic pancreatitis. In: Go VL (ed) The pancreas. Biology, pathobiology, and disease. New York; Raven Press 1993: 665-706
    Google Scholar
  • 167 Twersky Y, Bank S. Nutritional deficiencies in chronic pancreatitis 1.  Gastroenterol Clin North Am. 1989;  18 543-565
    PubMedGoogle Scholar
  • 168 Steer M L, Waxman I, Freedman S. Chronic pancreatitis 4.  N Engl J Med. 1995;  332 1482-1490
    CrossrefPubMedGoogle Scholar
  • 169 Havala T, Shronts E, Cerra F. Nutritional support in acute pancreatitis 1.  Gastroenterol Clin North Am. 1989;  18 525-542
    PubMedGoogle Scholar
  • 170 Holt S. Chronic pancreatitis 3.  South Med J. 1993;  86 201-207
    PubMedGoogle Scholar
  • 171 Latifi R, McIntosh J K, Dudrick S J. Nutritional management of acute and chronic pancreatitis 1.  Surg Clin North Am. 1991;  71 579-595
    PubMedGoogle Scholar
  • 172 DiMagno E P. Medical treatment of pancreatic insufficiency 7.  Mayo Clin Proc. 1979;  54 435-442
    PubMedGoogle Scholar
  • 173 Scolapio J S, Malhi-Chowla N, Ukleja A. Nutrition supplementation in patients with acute and chronic pancreatitis 1.  Gastroenterol Clin North Am. 1999;  28 695-707
    CrossrefPubMedGoogle Scholar
  • 174 Caliari S, Benini L, Sembenini C, Gregori B, Carnielli V, Vantini I. Medium-chain triglyceride absorption in patients with pancreatic insufficiency 1.  Scand J Gastroenterol. 1996;  31 90-94
    CrossrefPubMedGoogle Scholar
  • 175 DiMagno E P, Malagelada J R, Go V L, Moertel C G. Fate of orally ingested enzymes in pancreatic insufficiency. Comparison of two dosage schedules 2.  N Engl J Med. 1977;  296 1318-1322
    PubMedGoogle Scholar
  • 176 Graham D Y. Enzyme replacement therapy of exocrine pancreatic insufficiency in man. Relations between in vitro enzyme activities and in vivo potency in commercial pancreatic extracts 5.  N Engl J Med. 1977;  296 1314-1317
    PubMedGoogle Scholar
  • 177 Whitehead A M. Study to compare the enzyme activity, acid resistance and dissolution characteristics of currently available pancreatic enzyme preparations 1.  Pharm Weekbl Sci. 1988;  10 12-16
    PubMedGoogle Scholar
  • 178 Regan P T, Malagelada J R, DiMagno E P, Glanzman S L, Go V L. Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency 2.  N Engl J Med. 1977;  297 854-858
    CrossrefPubMedGoogle Scholar
  • 179 Suzuki A, Mizumoto A, Sarr M G, DiMagno E P. Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency: a new therapy of steatorrhea? 2.  Gastroenterology. 1997;  112 2048-2055
    CrossrefPubMedGoogle Scholar
  • 180 Malesci A, Mariani A, Mezzi G, Bocchia P, Basilico M. New enteric-coated high-lipase pancreatic extract in the treatment of pancreatic steatorrhea 1.  J Clin Gastroenterol. 1994;  18 32-35
    PubMedGoogle Scholar
  • 181 Taubin H L, Spiro H M. Nutritional aspects of chronic pancreatitis 1.  Am J Clin Nutr. 1973;  26 367-373
    PubMedGoogle Scholar
  • 182 Heijerman H G, Lamers C B, Bakker W. Omeprazole enhances the efficacy of pancreatin (pancrease) in cystic fibrosis 3.  Ann Intern Med. 1991;  114 200-201
    PubMedGoogle Scholar
  • 183 Halgreen H, Pedersen N T, Worning H. Symptomatic effect of pancreatic enzyme therapy in patients with chronic pancreatitis 2.  Scand J Gastroenterol. 1986;  21 104-108
    PubMedGoogle Scholar
  • 184 Ramo O J, Puolakkainen P A, Seppala K, Schroder T M. Self-administration of enzyme substitution in the treatment of exocrine pancreatic insufficiency 1.  Scand J Gastroenterol. 1989;  24 688-692
    PubMedGoogle Scholar
  • 185 Sampson H A. Food allergy. Part 1: Immunopathogenesis and clinical disorders.  J Allergy Clin Immunol. 1999;  103 717-728
    PubMedGoogle Scholar
  • 186 Bischoff S C, Manns M P. Nahrungsmittelallergien.  Internist. 2001;  42 1108-1117
    CrossrefPubMedGoogle Scholar
  • 187 Bischoff S C, Herrmann A, Mayer J, Manns M P. Food allergy in patients with gastrointestinal disease.  Monogr Allergy. 1996;  32 130-142
    PubMedGoogle Scholar
  • 188 Bruijnzeel-Koomen C, Ortolani C, Aas K, Bindslev-Jensen C, Björkstén B, Moneret-Vautrin D, Wüthrich B. Adverse reactions to food.  Allergy. 1995;  50 623-635
    CrossrefPubMedGoogle Scholar
  • 189 Schoetzau A, Gehring U, Wichmann H. Prospective cohort studies using hydrolysed formulas for allergy prevention in atopy-prone newborns: a systematic review.  Eur J Pediatr. 2001;  160 323-332
    PubMedGoogle Scholar
  • 190 Niggemann B, Binder C, Dupont C, Hadji S, Arvola T, Isolauri E. Prospective, controlled, multi-center study on the effect of an amino-acid-based formula in infants with cow's milk allergy/intolerance and atopic dermatitis.  Pediatr Allergy Immunol. 2001;  12 78-82
    CrossrefPubMedGoogle Scholar
  • 191 Munkvad M, Danielsen L, Hoj L, Povlsen C O, Secher L, Svejgaard E, Bundgaard A, Larsen P O. Antigen-free diet in adult patients with atopic dermatitis. A double-blind controlled study.  Acta Derm Venereol. 1984;  64 524-528
    PubMedGoogle Scholar
  • 192 Hoj L, Osterballe O, Bundgaard A, Weeke B, Weiss M. A double-blind controlled trial of elemental diet in severe, perennial asthma.  Allergy. 1981;  36 257-262
    PubMedGoogle Scholar

Prof. Dr. med. Heinrich Lübke

Zentralklinik Emil von Behring · Department Behring Krankenhaus

Gimpelsteig 3 - 3

14165 Berlin

Email: hlueb@zedat.fu-berlin.de

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