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Semin Liver Dis 2001; 21(4): 501-516
DOI: 10.1055/s-2001-19031
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Congenital Disorders of Glycosylation and the Pediatric Liver

Hudson H. Freeze
  • Glycobiology and Carbohydrate Chemistry Program, The Burnham Institute, La Jolla, California
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Publication History

Publication Date:
17 December 2001 (online)

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ABSTRACT

Congenital disorders of glycosylation (CDG) are caused by defects in protein N-glycosylation. These inherited disorders impact multiple organ systems, including the liver, its glycoprotein products, and the gastrointestinal system. Many patients have hypotonia, psychomotor retardation, developmental delay, and failure to thrive. Limited awareness of CDG and the diverse biological functions of glycosylation contribute to underdiagnosis of these disorders. Pediatric hepatologists and gastroenterologists are likely to encounter CDG patients early on in their workups. This review will discuss the clinical pictures, biochemistry, molecular defects, diagnosis, and, for one type, an effective treatment. The broad and diverse CDG presentations within and between the various types indicate that it should be considered in any case of unexplained developmental delay, hepatopathology, especially hepatic fibrosis and/or steatosis, protein-losing enteropathy, coagulopathy, hypoglycemia, and failure to thrive.

KEYWORD

Congenital disorders of glycosylation - N-linked glycosylation - congenital hepatic fibrosis - mannose - coagulopathy - protein-losing enteropathy

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