Pharmacopsychiatry 2001; 34(1): 6-12
DOI: 10.1055/s-2001-15186
Original Paper
© Georg Thieme Verlag Stuttgart · New York

The Utilization of Antidepressants in Community-Dwelling
and Institutionalized Elderly - Results from a Representative Survey in Germany

S. G. Riedel-Heller, H. Matschinger, A. Schork, M. C. Angermeyer
  • Department of Psychiatry, University of Leipzig, Germany
Further Information

Publication History

Publication Date:
31 December 2001 (online)

Given its widespread occurrence and consequences, old-age depression has to be regarded as a major public health problem. Drug treatment has been proven effective in the majority of elderly individuals suffering from depression. This study presents epidemiological data from pharmacological study regarding the use of prescribed antidepressants and those purchased over the counter in the elderly. Furthermore, it links the data to simultaneously assessed depressive symptomatology. A representative survey on the utilization of prescription and over-the-counter antidepressant drugs and depressive symptomatology in community-dwelling (n = 1193) and institutionalized elderly individuals (n = 470) aged 75 and over was conducted in an urban region of Germany. Antidepressant use was found to be remarkably low (synthetic antidepressants: 2.2 % of community dwelling individuals, 3.6 % of institutionalized individuals; herbal drugs containing hypericum perforatum: 4.2 % of community dwelling individuals, 2.8 % of institutionalized individuals). Two-thirds of the individuals treated with synthetic antidepressants received tri- and tetracyclic drugs, which were given at lower dosages than recommended for depression treatment. Selective serotonin reuptake inhibitors (SSRIs) were introduced in community-dwelling individuals only; none of the individuals cared for in residential and nursing homes received SSRIs. Only a minority of individuals with depressive symptoms were treated with antidepressants. The data suggests underutilization of antidepressants in the elderly, in which institutionalized elderly seem especially disadvantaged. The results call for incresed efforts to discuss mental health issues in the public and to share scientific knowledge about symptoms, course and treatment options for depression. Furthermore, geronto-psychiatric competence of medical professionals, especially GPs, has to be systematically developed.

References

  • 1 Angermeyer M C, Matschinger H, Riedel-Heller S G. Whom to ask for help in case of a mental disorder? Preferences of the lay public.  Soc Psychiatry Psychiatr Epidemiol. 1999;  34 202-210
  • 2 Barbui C, Campomori A, D'Avanzo B, Negri E, Garattini S. Antidepressant drug use in Italy since the introduction of SSRIs: national trends, regional differences and impact on suicide rates.  Soc Psychiatry Psychiatr Epidemiol. 1999;  34 52-156
  • 3 Bickel H. Epidemiologie psychischer Erkrankungen im Alter. In: Förstl H (ed) Lehrbuch der Gerontopsychiatrie. Stuttgart; Enke 1997: 1-15
  • 4 Bingefors K, Isacson D, von Knorring L. Antidepressant dose patterns in Swedish clinical practice.  Int Clin Psychopharmacol. 1997;  12 283-290
  • 5 Bingefors K A, Isacson D G, von Knorring L, Smedby B. Prescription drug and healthcare use among Swedish patients treated with antidepressants.  Ann Pharmacother. 1995;  29 566-572
  • 6 Brown S L, Salive M E, Guralnik J M, Pahor M, Chapman D P, Blazer D. Antidepressant use in the elderly: association with demographic characteristics, health-related factors, and health care utilization.  J Clin Epidemiol. 1995;  48 445-453
  • 7 Callahan C M, Hui S L, Nienaber N A, Musick B S, Tierney W M. Longitudinal study of depression and health services use among elderly primary care patients.  J Am Geriatr Soc. 1994;  42 833-838
  • 8 Conwell Y, Duberstein P R, Cox C, Herrmann J H, Forbes N T, Caine E D. Relationships of age and axis I diagnoses in victims of completed suicide: a psychological autopsy study.  Am J Psychiatry. 1996;  153 1001-1008
  • 9 Czekalla J, Gastpar M, Hubner W D, Jager D. The effect of hypericum extract on cardiac conduction as seen in electrocariogram compared to that of imipramine.  Pharmacopsychiatry. 1997;  30 (Suppl 2) 86-88
  • 10 Damitz B M. Drug utilization by elderly patients in Bremen old age and nursing homes with special reference to psychotropic drugs.  Gesundheitswesen. 1997;  59 83-86
  • 11 Deltito J, Beyer D. The scientific, quasi-scientific and popular literature on the use of St. John's Wort in the treatment of depression.  J Affect Disord. 1998;  51 345-351
  • 12 Dunham N C, Sager M A. Functional status, symptoms of depression, and the outcomes of hospitalization in community-dwelling elderly patients.  Arch Fam Med. 1994;  3 676-680
  • 13 Egberts A C, Leufkens H G, Hofman A, Hoes A W. Incidence of antidepressant drug use in older adults and association with chronic dizeases: the Rotterdam Study.  Int Clin Psychopharmacol. 1997;  12 217-223
  • 14 Folstein M F, Folstein S E, McHugh P R. Mini-Mental-State: A practical method for grading cognitive state of patients for the clinician.   J Psychiat Res. 1975;  12 189-198
  • 15 Formann A. Die Latent-Class Analyse. Weinheim; Beltz 1984
  • 16 Ganguli M, Mulsant B, Richards S, Stoehr G, Mendelsohn A. Antidepressant use over time in a rural older adult population: the MoVIES Project.  J Am Geriatr Soc. 1997;  45 1501-1503
  • 17 Ganzini L, Smith D M, Fenn D S, Lee M A. Depression and mortality in medically ill older adults.  J Am Geriatr Soc. 1997;  45 307-312
  • 18 Gareri P, Stilo G, Bevacqua I, Mattace R, Ferreri G, De Sarro G. Antidepressant drugs in the elderly.  Gen Pharmacol. 1998;  30 465-475
  • 19 Hallas J, Gaist D, Bjerrum L. The waiting time distribution as a graphical approach to epidemiologic measures of drug utilization.  Epidemiology. 1997;  8 666-670
  • 20 Harrison R, Savla N, Kafetz K. Dementia, depression and physical disability in a London borough: a survey of elderly people in and out of residential care and implications for future developments. Age.  Ageing. 1990;  19 97-103
  • 21 Hautzinger M, Bailer M. ADS - Allgemeine Depressionsskala, Manual. Beltz Test 1993
  • 22 Heston L L, Garrard J, Makris L, Kane R L, Cooper S, Dunham T, Zelterman D. Inadequate treatment of depressed nursing home elderly.  J Am Geriatr Soc. 1992;  40 1117-1122
  • 23 Josey E S, Tackett R L. St. John's wort: a new alternative for depression?.  Int J Clin Pharmacol Ther. 1999;  37 111-119
  • 24 Kuhn R. The treatment of depressive states with G22355 (imipramine hydrochloride).  Am J Psychiatry. 1958;  115 459-464
  • 25 Laakmann G, Schule C, Baghai T, Kieser M. St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy.  Pharmacopsychiatry. 1998;  31 (Suppl 1) 54-59
  • 26 Lassila H C, Stoehr G P, Ganguli M, Seaberg E C, Gilby J E, Belle S H, Echement D A. Use of prescription medications in an elderly rural population: the MoVIES Project.  Ann Pharmacother. 1996;  30 589-595
  • 27 Lebowitz B D, Pearson J L, Schneider L S, Reynolds C F3, Alexopoulos G S, Bruce M L, Conwell Y, Katz I R, Meyers B S, Morrison M, Mossey J, Niederehe G, Parmelee P. Diagnosis and treatment of depression in late life. Consensus statement update.  JAMA. 1997;  278 1186-1190
  • 28 Lecrubier Y. Is depression under-recognized and undertreated?.  Int Clin Psychopharmacol. 1998;  13 (Suppl 5) S3-6
  • 29 Lepine J P, Gastpar M, Mendlewicz J, Tylee A. Depression in the community: the first pan-European study DEPRES (Depression Research in European Society).  Int Clin Psychopharmacol. 1997;  12 19-29
  • 30 Matschinger H, Schork A, Riedel-Heller S G, Angermeyer M C. Zur Anwendung der CES-D bei älteren Menschen: Dimensionsstruktur und Messartefakte.  Diagnostica. 2000;  46 29-37
  • 31 Phillips C J, Henderson A S. The prevalence of depression among Australian nursing home residents: results using draft ICD-10 and DSM-III-R criteria.  Psychol Med. 1991;  21 739-748
  • 32 Radloff L S. The CES-D Scale: A self-report depression scale for research in the general Population.  Applied Psychological Measurement. 1977;  1 385-401
  • 33 Rosholm J U, Gram L F, Isacsson G, Hallas J, Bergman U. Changes in the pattern of antidepressant use upon the introduction of the new antidepressants: a prescription database study.  Eur J Clin Pharmacol. 1997;  52 205-209
  • 34 Rote Liste. Arzneimittelverzeichnis des Bundesverbandes der Pharmazeutischen Industrie. Aulendorf; Editio Cantor Verlag für Medizin und Naturwissenschaften GmbH 1998
  • 35 Roth M, Tym E, Mountjoy E, Huppert C Q, Hendrie F A, Verma H, Goddard S. CAMDEX: a standardized instrument for the diagnosis of mental disorder in the elderly with special reference to early detection of dementia.  Br J Psychiatr. 1986;  149 698-709
  • 36 Rovner B W, German P S, Brant L J, Clark R, Burton L, Folstein M F. Depression and mortality in nursing homes.  JAMA. 1991;  265 993-996
  • 37 Rutz W, Carlsson P, von Knorring L, Walinder J. Cost-benefit analysis of an educational program for general practitioners by the Swedish Committee for the Prevention and Treatment of Depression.  Acta Psychiatr Scand. 1992a;  85 457-464
  • 38 Rutz W, Walinder J, Eberhard G, von Knorring A L, von Knorring L, Wistedt B, Aberg-Wistedt A. Prevention of suicide. The Swedish PTD Committee.  Lancet. 1992b;  340 1233-1234
  • 39 Sandholzer H, Stoppe G, Muder C, Rüther E, Kochen M M. Die Pharmakotherapie der Depression in der hausärztlichen Praxis. Edited by Radebold, H., R.D. Hirsch, J. Kipp, R. Kortus, G. Stoppe, B. Struwe, C. Wächtler. Depressionen im Alter. Darmstadt; Steinkopff 1997: 196-199
  • 40 Schumacher J, Zedlick D, Frenzel G. Depressivität und kognitive Beeinträchtigungen bei Altenpflegeheim-Bewohnern.  Z Gerontol Geriat. 1997;  30 46-30
  • 41 Snowdon J, Vaughan R, Miller R, Burgess E E, Tremlett P. Psychotropic drug use in Sydney nursing homes.  Med J Aust. 1995;  163 70-72
  • 42 Spore D, Mor V, Hiris J, Larrat E P, Hawes C. Psychotropic use among older residents of board and care facilities.  J Am Geriatr Soc. 1995;  43 1403-1409
  • 43 Stuck A E, Beers M H, Steiner A, Aronow H U, Rubenstein L Z, Beck J C. Inappropriate medication use in community-residing older persons.  Arch Intern Med. 1994;  154 2195-2200
  • 44 Stuck A E, Gloor B D, Pfluger D H, Minder C E, Beck J C. Sex differences in drug use by over 75-year-old persons at home: an epidemiologic study in Bern.  Z Gerontol Geriatr. 1995;  28 394-400
  • 45 Turrina C, Zimmermann-Tansella C, Micciolo R, Siciliani O. A community survey of psychotropic drug consumption in South Verona: prevalence and associated variables.  Soc Psychiatry Psychiatr Epidemiol. 1993;  28 40-44
  • 46 Volz H P. Controlled clinical trails of hypericum extracts in depressed patients - an overview.  Pharmacopsychiatry. 1997;  30 (Suppl 2) 72-76
  • 47 Weatley D. LI 160, an extract of St. John's wort, versus amitriptyline in mildly to moderately depressed outpatients - a 6 week controlled clinical trial.  Pharmacopsychiatry. 1997;  30 (Suppl 2) 77-80
  • 48 Wells K B, Stewart A, Hays R D, Burnam M A, Rogers W, Daniels M, Berry S, Greenfield S, Ware J. The functioning and well-being of depressed patients. Results from the Medical Outcomes Study.  JAMA. 1989;  262 914-919
  • 49 Weyerer S, Häfner H, Mann A H, Ames D, Graham N. Prevalence and course of depression among elderly residential home admissions in Mannheim and Camden, London.  Int Psychogeriatr. 1995;  7 479-493
  • 50 Wittchen H U, Schuster P, Pfister H, Müller N, Storz S, Izensee B. Depressionen in der Allgemeinbevölkerung - schlecht erkannt und selten behandelt.  Nervenheilkunde. 1999a;  18 202-209
  • 51 Wittchen H U, Schuster P, Pfister H, Gander F, Müller N. Warum werden Depressionen häufig nicht erkannt und selten behandelt?.  Nervenheilkunde. 1999b;  18 210-217
  • 52 Zimber A, Gaeth K, Weyerer S. Functional impairment, behavior disturbances, and social activities among residents of an old age home: How reliable are assessments by the home staff?.  Zeitschrift für Gerontopsychologie und -psychiatrie. 1996;  9 167-179
  • 53 Zimber A, Schäufele M, Weyerer S. Changes in homes for the aged and nursing homes: functional impairments and behavioral disorders of residents are increasing.  Gesundheitswesen. 1998;  60 239-246

Dr. med. Steffi G. Riedel-Heller MPH

Department of Psychiatry,
University of Leipzig

Johannisallee 20

04317 Leipzig

Germany

Phone: 0049 (341) 972 45 30

Fax: 0049 (341) 972 45 39

Email: ries@server3.medizin.uni-leipzig.de

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