Primary Localized Cutaneous Nodular Amyloidosis of the Cheeks

 

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Abstract

We report the rare case of a primary localized cutaneous nodular amyloidosis (PLCNA), which clinically appeared as waxy, yellow-red infiltrated plaques with telangiectasia on the face of a 52-year-old woman. Diagnosis was confirmed by immunohistochemistry results. Histologically, diffuse amyloid tissue infiltration could be revealed. Amyloid stained positive for lambda, but negative for kappa light chain antibodies whereas no proliferation of clonal plasma cells in the bone marrow was found.

Zusammenfassung

Wir berichten über den seltenen Fall einer primär lokalisierten kutanen nodulären Amyloidose (PLNCA), die sich wachsartig mit gelb-rot infiltrierten Plaques an der Gesichtshaut einer 52-jährigen Frau zeigte. Die Diagnose wurde immunhistochemisch bestätigt. Es fand sich eine diffuse Amyloid-Infiltration mit positiver Färbung für Lambda- und negativer für Kappa-Leichtketten-Antikörper ohne Proliferation der klonalen Plasmazellen ins Knochenmark.

• References

• 1 Schreml S, Schroeder J, Eder F. et al. Hereditary and non-hereditary cutaneous amyloidoses. Pathologe 2009; 30: 197-204
  CrossrefPubMedGoogle Scholar
• 2 Misumi Y, Ando Y. Classification of amyloidosis. Brain Nerve 2014; 66: 731-737
  PubMedGoogle Scholar
• 3 Zhai Z, Hao F, Song Z. et al. Primary localized cutaneous nodular amyloidosis of the thighs. Cutis 2015; 95: E24-27
  PubMedGoogle Scholar
• 4 Verma SB, Khopkar U. Bilateral recurrent facial primary cutaneous nodular amyloidosis (PCNA). JAAD Case Rep 2016; 2: 31-33
  PubMedGoogle Scholar
• 5 Kaltoft B, Schmidt G, Lauritzen AF. et al. Primary localised cutaneous amyloidosis – a systematic review. Dan Med J 2013; 60: A4727
  PubMedGoogle Scholar
• 6 Cai YX, Li SJ, Zhou Y. et al. Immunohistochemical study of immunoglobulin light chains and inflammatory cells in a patient with localized primary cutaneous nodular amyloidosis. J Eur Acad Dermatol Venereol 2016; 30: 469-470
  CrossrefPubMedGoogle Scholar
• 7 Wey SJ, Chen YM, Lai PJ. et al. Primary Sjögren syndrome manifested as localized cutaneous nodular amyloidosis. J Clin Rheumatol 2011; 17: 368-370
  CrossrefPubMedGoogle Scholar
• 8 Tong PL, Walker WA, Glancy RJ. et al. Primary localized cutaneous nodular amyloidosis successfully treated with cyclophosphamide. Australian Journal of Dermatology 2013; 54: e12-e15
  CrossrefPubMedGoogle Scholar
• 9 Ung CY, Carr NJ, Ardern-Jones MR. Primary cutaneous nodular amyloidosis associated with psoriasis. Clin Exp Dermatol 2014; 39: 608-611
  CrossrefPubMedGoogle Scholar
• 10 Terushkin V, Boyd KP, Patel RR. et al. Primary localized cutaneous amyloidosis. Dermatol Online J 2013; 19: 20711
  PubMedGoogle Scholar
• 11 Elghetany MT, Saleem A, Barr K. The congo red stain revisited. Ann Clin Lab Sci 1989; 19: 190-195
  PubMedGoogle Scholar
• 12 Clos AL, Lasagna-Reeves CA, Castillo-Carranza DL. et al. Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis. Br J Dermatol 2011; 165: 1349-1354
  CrossrefPubMedGoogle Scholar
• 13 Raymond J, Choi J. Nodular cutaneous amyloidosis effectively treated with intralesional methotrexate. JAAD Case Rep 2016; 2: 373-376
  PubMedGoogle Scholar
• 14 Schucht K, Schröder J, Siegmund H. et al. Nodular Cutaneous Amyloidosis at the Temple. Case Rep Dermatol 2016; 8: 193-196
  CrossrefPubMedGoogle Scholar
• 15 Lesiak A, Rakowski A, Brzezinska A. et al. Effective treatment of nodular amyloidosis with carbon dioxide laser. J Cutan Med Surg 2012; 16: 372-374
  CrossrefPubMedGoogle Scholar
• 16 Alster TS, Manaloto RM. Nodular amyloidosis treated with a pulsed dye laser. Dermatol Surg 1999; 25: 133-135
  CrossrefPubMedGoogle Scholar
• 17 Vestey JP, Tidman MJ, Mclaren KM. Primary nodular cutaneous amyloidosis – long-term follow-up and treatment. Clin Exp Dermatol 1994; 19: 159-162
  CrossrefPubMedGoogle Scholar