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CC BY 4.0 · Arq Neuropsiquiatr 2022; 80(08): 831-836
DOI: 10.1055/s-0042-1755229
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Recording cutaneous silent period parameters in hereditary and acquired neuropathies

Registro do período de silêncio cutâneo em neuropatias adquiridas e hereditárias
Eduardo Luis de A. Neves 
1   Universidade Federal de Sergipe, Programa de Pós-Gradução em Ciências da Saúde, Aracaju SE, Brazil.
,
José Rodrigo S. Silva 
2   Universidade Federal de Sergipe, Departamento de Estatística e Ciências Atuariais, Aracaju SE, Brazil.
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Abstract

Background Cutaneous silent period (CSP) is the interruption in muscle activity after painful stimulation of a sensory nerve.

Objective The aim of the present study is to assess CSP changes in patients with polyneuropathy (PNP).

Methods The present study was carried out to assess CSP in individuals with diabetes (DM) and Charcot-Marie-Tooth (CMT) disease. The sample comprised 24 individuals with DM, 10 individuals with CMT1 disease, and 10 individuals with CMT2 disease. The control group (CG) consisted of 59 individuals.

Results The mean latencies recorded for the upper limbs in the CG were 79.2 milliseconds (onset latency), 69.3 milliseconds (50% reduction latency), 112.2 milliseconds (end latency), and 33.1 milliseconds (CSP duration). On the other hand, the mean latencies recorded for the lower limbs were 99.0 milliseconds (onset latency), 85.0 milliseconds (50% reduction latency), 136.9 milliseconds (end latency), and 38.2 milliseconds (CSP duration). The mean latencies recorded for the CG were significantly lower than the ones recorded for other groups, both in the upper and lower limbs.

Conclusions Cutaneous silent period values recorded for the CG in the present study were close to the ones reported in studies available in the literature. Abnormal CSP parameters were observed in the group of individuals with PNP. The end latency in the lower limbs helped differentiating the demyelinating subgroup from the axonal one.

Resumo

Antecedentes Período de silêncio cutâneo (PSC) é uma interrupção da atividade muscular após a estimulação dolorosa de um nervo sensitivo.

Objetivo O presente estudo tem como objetivo avaliar alterações do PSC em indivíduos com polineuropatia.

Métodos O presente estudo avaliou PSC em indivíduos com diabetes mellitus (DM) e com doença de Charcot-Marie-Tooth (CMT). A amostra compreendia 24 indivíduos com DM, 10 indivíduos com CMT tipo 1 e 10 indivíduos com CMT tipo 2. Um grupo controle continha 59 indivíduos.

Resultados A média das latências do PSC registradas nos membros superiores no grupo controle foi 79,2 milissegundos (latência de início), 69,3 milissegundos (latência com redução de 50%), 112,2 milissegundos (latência final) e 33,1 milissegundos (duração do PSC). Por outro lado, a média das latências do PSC registradas nos membros inferiores foi 99,0 milissegundos (latência de início), 85,0 milissegundos (latência com redução de 50%), 136,9 milissegundos (latência final) e 38,2 milissegundos (duração do PSC). A média das latências registradas no grupo controle foi significativamente menor do que as registradas nos outros grupos (DM e CMT), tanto nos membros inferiores quanto nos superiores.

Conclusões Os valores do PSC registrados no grupo controle no presente estudo estiveram próximos aos reportados na literatura. Parâmetros anormais foram observados no grupo de indivíduos com polineuropatia. A latência final do PSC obtida nos membros inferiores ajudou a diferenciar os subgrupos desmielinizantes e axonais.

Keywords

Diabetes Mellitus - Charcot-Marie-Tooth Disease - Neural Conduction - Diabetic Neuropathies - Electromyography

Palavras-chave

Diabetes Mellitus - Doença de Charcot-Marie-Tooth - Condução Nervosa - Neuropatias Diabéticas - Eletromiografia

Authors' Contributions

ELAN: study design and conceptualization; major role in data acquisition; data interpretation; revision of the intellectual content of the manuscript; JRSS: data interpretation; revision of the intellectual content of the manuscript.




Publication History

Received: 06 April 2021

Accepted: 06 December 2021

Article published online:
17 October 2022

© 2022. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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