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Thromb Haemost 1979; 42(02): 556-563
DOI: 10.1055/s-0038-1666893
Original Article
Schattauer GmbH Stuttgart

Decreased Heparin Sensitivity of Cyclohexanedione-Modified Factor Xa

György Blaskó
The Postgraduate Medical School, First Department of Medicine, 1389 Budapest, Hungary
,
Raymund Machovich
The Postgraduate Medical School, First Department of Medicine, 1389 Budapest, Hungary
› Author Affiliations
Further Information

Publication History

Received 21 June 1978

Accepted 28 August 1978

Publication Date:
23 August 2018 (online)

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Summary

Modification of 12 arginine residues of bovine Factor Xa with 1,2-cyclohexanedione has resulted in a decrease in heparin sensitivity of the reaction between enzyme and antithrombin-III, whereas the antithrombin-III sensitivity of modified Factor Xa was only slightly affected. It is suggested that heparin accelerates the Factor Xa-antithrombin-III reaction by interacting with Factor Xa.

 

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