Thromb Haemost 1997; 78(02): 845-851
DOI: 10.1055/s-0038-1657639
Rapid Communication
Schattauer GmbH Stuttgart

Effect of Strenuous Exercise on Fibrinogen and Fibrinolysis in Healthy Elderly Men and Women

Albertine J Schuit
1   The Department of Epidemiology and Public Health, Agricultural University Wageningen, Leiden, The Netherlands
,
Evert G Schouten
1   The Department of Epidemiology and Public Health, Agricultural University Wageningen, Leiden, The Netherlands
,
Cornelis Kluft
2   The TNO Prevention and Health, Gaubius Laboratory, Division of Vascular and Connective Tissue Research, Leiden
,
Moniek de Maat
2   The TNO Prevention and Health, Gaubius Laboratory, Division of Vascular and Connective Tissue Research, Leiden
,
Paul P C A Menheere
3   The Department of Clinical Chemistry, University Hospital, Maastricht, The Netherlands
,
Frans J Kok
1   The Department of Epidemiology and Public Health, Agricultural University Wageningen, Leiden, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 22 1996

Accepted after revision 08 April 1997

Publication Date:
12 July 2018 (online)

Summary

The elevated incidence of thrombotic disease in elderly people may be associated with an increase in PAI-1 and fibrinogen with ageing. Cross-sectional studies report an inverse relation of PAI-1 and fibrinogen with physical activity, but training studies show inconsistent results. In a controlled intervention study among elderly subjects (aged 60-80 years) we observed a moderate decrease in PAI-1 antigen (4%, -2.1 ± 2.4 ng/ml), a significant increase in t-PA activity (11%, 0.07 ± 0.04 IU/ml) and an unexpected significant increase in fibrinogen (6%, 0.18 ± 0.07 g/1) in subjects following a 6-month intensive training program as compared to controls. Reduction in PAI-1 antigen was significantly associated with a decrease in triglycerides (β = 10.3 ng/ml per 1 mM, p <0.01) and insulin (β = 2.37 ng/ml per 1 mU/1, p = 0.07). Increase in fibrinogen coincided with a rise in C-reactive protein (p <0.001). These data suggest that regular intensive activity may increase fibrinolytic activity in a moderate way, but also may cause chronically elevated plasma levels of acute phase proteins in elderly persons.

 
  • References

  • 1 Ernst E. Fibrinogen as a cardiovascular risk factor: a meta-analysis and review of the literature. Ann Int Med 1993; 118: 956-963
  • 2 Eriksson P, Kallin B, van’t Hooft FM, Bavenholm P, Hamsten A. Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction. Proc Natl Acad Sci USA 1995; 92: 1851-1855
  • 3 Qizilbash N, Jones L, Warlow CH, Mann J. Fibrinogen and lipid concentrations as risk factors for transient ischaemic attacks and minor ischaemic strokes. Br Med J 1991; 303: 605-609
  • 4 Ishida T, Tanaka K. Effect of fibrin and fibrinogen-degradation products on the growth of rabbit aortic smooth muscle cells in vitro. Atherosclerosis 1982; 44: 161-174
  • 5 Naito M, Hayashi T, Kuzuya M, Funaki C, Asai K, Kuzuya F. Effects of fibrinogen and fibrin on the migration of vascular smooth muscle cells in vitro. Atherosclerosis 1990; 83: 9-14
  • 6 Peerschke EIB. The platelet fibrinogen receptor. Sem Haem 1985; 23: 241-259
  • 7 Leschke M, Blanke H, Styellwaag M, Motz W, Strauer BE. Hyperfibrinogenämie und pathologische Plasmaviskosität. Dtsch Med Wsch 1988; 113: 1175-1181
  • 8 Krobot K, Hense HW, Cremer P, Eberle E, Keil U. Determinants of plasma fibrinogen: relation to body weight, waist-to-hip rate, smoking, alcohol, age and sex. Arteriosclerosis and Thrombosis 1992; 12: 786-788
  • 9 Folsom AR, Wu KK, Davis CE, Conlan MG, Sorlie PP, Szklo M. Population correlated of plasma fibrinogen and factor VII putative cardiovascular risk factors. Atherosclerosis 1991; 91: 191-205
  • 10 Cigolini M, Targher G, Seidell JC, Schiavon R, Manara F, Zenti MG, Mat-tioli C, De SandreG. Relationships of plasminogen activator inhibitor-1 to anthropometry, serum insulin, triglycerides and adipose tissue fatty acids in healthy men. Atherosclerosis 1994; 106: 139-147
  • 11 Vague P, Raccah D, Seelies V. Hypofibrinolysis and the insulin resistance syndrome. Int J Obesity 1995; 19: 911-915
  • 12 Mehta J, Mehta P, Dawson D, Saldeen T. Plasma tissue plasminogen activator inhibitor levels in coronary artery disease: correlation with age and serum triglyceride concentration. J Am Coll Cardiol 1987; 9: 263-268
  • 13 Aillaud MF, Pignol F, Alessi MC, Harle JR, Esconde M, Mongin M, Juhan-Vague I. Increase in plasma concentration of plasminogen activator inhibitor, fibrinogen, von Willenbrand factor, factor VII:C and in erythrocyte sedimentation rate with age. Thromb Haemost 1986; 55: 330-322
  • 14 Lindoff C, Petersson F, Lecander I, Martinsson G, Astedt B. Passage of menopause is followed by haemostatic changes. Maturitas 1993; 17: 17-22
  • 15 Rankinen T, Rauramaa R, Väisänen S, Penttilä IM, Uusitupa M. Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors. Thromb Haemost 1994; 71: 180-183
  • 16 Szymanski LM, Pate RR. Fibrinolytic responses to moderate intensity exercise, comparison of physically active and inactive men. Arteriosclerosis and Thrombosis 1994; 14: 1746-1750
  • 17 Lakka TA, Salonen JK. Moderate to high intensity conditioning leisure time physical activity and high cardiorespiratory fitness are associated with reduced plasma fibrinogen in eastern Finnish men. J Clin Epidemiol 1993; 46: 1119-1127
  • 18 Stratton JR, Chandler WL, Schwartz RS, Cerquiera MD, Levy WC, Kahn SE, Larson VG, Cain KC, Beard JC, Abrass IB. Effect of physical conditioning on fibrinolytic variables and fibrinogen in young and old healthy adults. Circulation 1991; 83: 1692-1697
  • 19 Rankinen T, Rauramaa R, Väisänen S, Halonen P, Pent tilä. Blood coagulation and fibrinolytic factors are unchanged by aerobic exercise or fat modified diet. Randomized clinical trial in middle aged men. Fibrinolysis 1994; 8: 48-53
  • 20 De GeusEJC, Kluft C, de BartACW, van DoomenLJP. Efects of exercise training on plasminogen activator inhibitor activity. Med Sci Sports Exerc 1992; 24: 1210-1219
  • 21 Anderssen SA, Haaland A, Hjermann I, Urdal P, Gjesdal K, Holme I. Oslo diet and exercise study: a one-year randomized intervention trial. Effects on hemostatic variables and other coronary risk factors. Nutr Metab Cardio-vasc Dis 1995; 5: 189-200
  • 22 Ponjee GAE, Janssen EME, Hermans J, Vanwersch JWJ. Regular physical activity and change in risk factors for coronary heart disease: A nine months prospective study. Eur J Clin Chem Clin Biochem 1996; 34: 477-483
  • 23 El-Sayed MS, Davies B. A physical conditioning program does not alter fibrinogen concentration in young healthy subjects. Med Sci Sports Exerc 1995; 27: 485-489
  • 24 Kluft C, Meijer P. Update 1996: Blood collection and handling procedures for assessment of plasminogen activators and inhibitors (Leiden Fibrinolysis Workshop). Fibrinolysis 1996; 10 (Suppl. 02) 171-179
  • 25 Clauss Avon. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol 1957; 17: 237-246
  • 26 Meijer P, Pollet DE, Wauters J, Kluft C. Specificity of antigen assays of plasminogen activator inhibitor in plasma: Innotest PAI-1 immuno assay evaluated. Clin Chem 1994; 40: 110-115
  • 27 Lopez-Virella MF, Stone P, Ellis S, Colwell JA. Cholesterol determination in high density lipoproteins separated by three different methods. Clin Chem 1977; 23: 882-884
  • 28 Feunekes GIJ, Staveren vanWA, De VriesJHM, Burema J, Hautvast JGA. Relative and biomarker-based validity of a food frequency questionnaire estimating intake of fats and cholesterol. Am J Clin Nutr 1993; 58: 489-496
  • 29 Meade TW, Brozovic M, Chakrabarti RR, Haines AP, Imeson JD, Mellows S, Milles GJ, North WRS, Stirling Y, Thompson SG. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet 1986; 02: 533-537
  • 30 Kannel WB, Wolf PA, Castelli WP, D’Agostino RB. Fibrinogen and risk factors of cardiovascular disease. JAMA 1987; 258: 1183-1186
  • 31 Hamsten A, de FaireU, Walldius G, Dahlen G, Szamosi A, Landou C, Blomback M, Wiman B. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet 1987; 2: 3-9
  • 32 Munkvad S, Gram J, Jespersen J. A depression of active tissue plasminogen activator in plasma characterizes patients with unstable angina pectoris who develop myocardial infarction. Eur Heart J 1990; 11: 525-528
  • 33 Wosomu D, Allardyce W, Ballantyne D, Tansey P. Influence of power and aerobic exercise training on hemostatic factors after coronary artery surgery. Br Heart J 1992; 68: 181-186
  • 34 Montgomery HE, Clarkson P, Nwose OM, Mikailidis DP, Jagroop TA, Dollery C, Moult J, Benhizia F, Deanfield J, Jubb M, World M, McEwan JR, Winder A, Humphries S. The acute rise in plasma fibrinogen with exercise is influenced by G-453-A polymorphism of the b-fibrinogen gene. Ar-terioscl Thromb Vase Biol 1996; 16: 386-391
  • 35 Weight LM, Alexander D, Jacobs P. Strenuous exercise: analogous to the acute phase response?. Clin Sci Colch 1991; 81: 677-683
  • 36 Connely JB, Cooper JA, Meade TW. Strenuous exercise, plasma fibrinogen and factor VII activity. Br Heart J 1992; 67: 351-354
  • 37 Mattiasson I, Lindgärde F. The effect of psychosocial stress and risk factors for ischaemic heart disease on the plasma fibrinogen concentration. J Int Med 1993; 234: 45-51
  • 38 Markowe HU, Marmot MG, Shipley MJ, Bulpitt CJ, Meade TW, Stirling Y, Vickers MV, Semmence A. Fibrinogen a possible link between social class and coronary heart disease. Br Med J 1985; 291: 1312-1314
  • 39 Sundell EB, Nilsson TK, Rånby M, Hallmans G, Hellsten G. Fibrinolytic variables are related to age sex, blood pressure and body build measurement: a cross sectional study in Norsjö, Sweden. Am J Epidemiol 1989; 42: 719-723
  • 40 Mykkänen L, Rönnemaa T, Mamiemi J, Haffner SM, Bergman R, Laakso M. Insulin sensitivity is not an independent determinant of plasma plasminogen activator inhibitor-1 activity. Arterioscler Thromb 1994; 14: 126471
  • 41 Boman K, Hellsten G, Bruce A, Hallmans G, Nilsson T. Endurance physical activity, diet and fibrinolysis. Atherosclerosis 1994; 106: 65-74