Thromb Haemost 1995; 74(03): 996
DOI: 10.1055/s-0038-1649866
Letter to the Editor
Schattauer GmbH Stuttgart

APC-Resistance and Mnl I Genotype (Gin 506) of Coagulation Factor V Are Rare in Japanese Population

Osamu Takamiya
Department of Medical Technology, School of Allied Medical Sciences and The Second Department of Internal Medicine, School of Medicine, Shinshu University, Japan
,
Fumihiro Ishida
Department of Medical Technology, School of Allied Medical Sciences and The Second Department of Internal Medicine, School of Medicine, Shinshu University, Japan
,
Hiroshi Kodaira
Department of Medical Technology, School of Allied Medical Sciences and The Second Department of Internal Medicine, School of Medicine, Shinshu University, Japan
,
Kiyoshi Kitano
Department of Medical Technology, School of Allied Medical Sciences and The Second Department of Internal Medicine, School of Medicine, Shinshu University, Japan
› Author Affiliations
Further Information

Publication History

Received 27 February 1995

Accepted after revision 12 April 1995

Publication Date:
09 July 2018 (online)

 
  • References

  • 1 Gladson CL, Scharrer I, Hach V, Beck KH, Griffin JH. The frequency of type 1 heterozygous Protein S and Protein C deficiency in 141 unrelated young patients with venous thrombosis. Thromb Haemost 1988; 59: 18-22
  • 2 Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechnism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-1008
  • 3 Bertina RM, Koeleman BC P, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67
  • 4 Vooberg J, Roelse J, Koompman R, Buller H, Berends F, ten Cate JW, Mertens K, van Mourik JA. Association of idiopathic venous thromboembolism with single point-mutation at Arg506of factor V. Lancet 1994; 343: 1535-1536
  • 5 Koster T, Rosendaal FR, de Ronde H, Briet E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden thrombophilia study. Lancet 1993; 342: 1503-1506
  • 6 Tanabe T, Yasuda K, Sakuma M, Goh K, Matsui Y, Gouda T. Current status and problems of venous thrombosis in Japan. Surgery/Geka 1989; 51: 387-392 (In Japanese)