Thromb Haemost 1999; 81(01): 22-25
DOI: 10.1055/s-0037-1614411
Review Article
Schattauer GmbH

Prevention of Deep Vein Thrombosis after Hip Replacement

Comparison between Two Low-molecular-weight Heparins, Tinzaparin and Enoxaparin
André Planès
1   From Clinique Radio-Chirurgicale du Mail, La Rochelle, France
,
Meyer M. Samama
2   From Hôpital Hôtel Dieu, Paris, France,
,
Anthonie W. A. Lensing
3   From Academic Medical Center, Amsterdam, The Netherlands;
,
Harry R. Büller
3   From Academic Medical Center, Amsterdam, The Netherlands;
,
Jeanne Barre
4   From Hôpital Robert Debré, Reims, France
,
Nicole Vochelle
4   From Hôpital Robert Debré, Reims, France
,
Bertrand Beau
5   From LEO Laboratories, Saint Quentin en Yvelines, France
› Author Affiliations
Further Information

Publication History

Received04 December 1997

Accepted after resubmission16 September 1998

Publication Date:
08 December 2017 (online)

Summary

Consecutive patients undergoing total hip replacement in 43 centres were randomly assigned to receive blindly either enoxaparin (40 mg) or tinzaparin (4,500 anti-Factor IU Xa), as once daily subcutaneous injections. The first injection was administered 12 h preoperatively. Efficacy was assessed by bilateral venography performed 12-14 days postoperatively. Efficacy and safety were blindly and centrally adjudicated. Among the 499 patients included, 440 had a venogram. The total incidence of DVTs was 44 (20.1%) of the 219 patients of the enoxaparin group and 48 (21.7%) of the 221 patients of the tinzaparin group. The upper limit of the 80% confidence interval of the difference between the two treatment groups was less than 5.0%. Therefore according to the protocol’s specifications equivalence was shown. Proximal DVTs occurred in 10.5% of the enoxaparin group (23 patients) and in 9.5% (21 patients) of the tinzaparin group. No overt major bleeding was observed. One patient in the enoxaparin group developed severe thrombocytopenia and died. The LMWH tinzaparin appears clinically to be as effective and safe as enoxaparin in the prophylaxis of deep vein thrombosis after total hip replacement, at the doses used and under the conditions of this study.

 
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