Download PDF
Klin Monbl Augenheilkd 2015; 232(4): 587-589
DOI: 10.1055/s-0035-1545754
Der interessante Fall
Georg Thieme Verlag KG Stuttgart · New York

Paraneoplastic Vitelliform Retinopathy Secondary to Metastatic Melanoma

Paraneoplastische vitelliforme Retinopathie assoziiert mit metastatischem Melanom
P. G. Meier
1   Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, FAA, Lausanne, Switzerland (Chair: Prof. Francine Behar-Cohen)
,
A. Ambresin
1   Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, FAA, Lausanne, Switzerland (Chair: Prof. Francine Behar-Cohen)
,
C. E. Thirkill
2   Eye Research Center, Davis Medical Center, University of California, Sacramento, CA, USA (Chair: Prof. Mark Mannis)
,
F.-X. Borruat
1   Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, FAA, Lausanne, Switzerland (Chair: Prof. Francine Behar-Cohen)
,
A. Schalenbourg
1   Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, FAA, Lausanne, Switzerland (Chair: Prof. Francine Behar-Cohen)
› Author Affiliations
Further Information

Publication History

Publication Date:
22 April 2015 (online)

Also available at
    Permissions and Reprints

Background

Traditionally, the paraneoplastic retinopathies have been classified into two entities: CAR (carcinoma-associated retinopathy) and MAR (melanoma-associated retinopathy). Recently, a vitelliform retinopathy has been described in both metastatic cancer and melanoma patients: in 2001, Borkowksi reported the first patient as a case of MAR with unusual retinal features [1]. Since then, only 20 cases have been reported [2], [3], [4], [5]. This auto-immune disorder is caused by circulating autoantibodies, cross-reacting with the neuroretina and retinal pigment epithelium (RPE) [2].

 

  • References

  • 1 Borkowski LM, Grover S, Fishman GA et al. Retinal findings in melanoma associated retinopathy. Am J Ophthalmol 2001; 94: 273-275
    PubMedGoogle Scholar
  • 2 Aronow MA, Adamus G, Abu-Asab M et al. Paraneoplastic vitelliform retinopathy: clinicopathologic correlation and review of the literature. Surv Ophthalmol 2012; 57: 558-564
    CrossrefPubMedGoogle Scholar
  • 3 Saad A, Al-Dahmash SA, Shields CL et al. Acute exudative paraneoplastic polymorphous vitelliform maculopathy in five cases. Ophthalmic Surg Lasers Imaging 2012; 43: 366-373
    CrossrefPubMedGoogle Scholar
  • 4 Koreen L, He SX, Johnson MW. Anti-retinal pigment epithelium antibodies in acute exudative polymorphous vitelliform maculopathy. Arch Ophthalmol 2011; 129: 23-29
    CrossrefPubMedGoogle Scholar
  • 5 Javaheri M, Khurana RN, Bhatti RA. Optical coherence tomography findings in paraneoplastic pseudovitelliform lesions in melanoma-associated retinopathy. Clin Ophthalmol 2008; 2: 461-463
    PubMedGoogle Scholar
  • 6 Chan C, OʼDay J. Melanoma-associated retinopathy: does autoimmunity prolong survival?. Clin Exp Ophthalmol 2001; 29: 235-238
    CrossrefPubMedGoogle Scholar
  • 7 Spaide R. Autofluorescence from the outer retina and subretinal space. Retina 2008; 28: 5-35
    CrossrefPubMedGoogle Scholar
  • 8 Keltner JL, Thirkill CE, Yip PT. Clinical and immunologic characteristics of melanoma-associated retinopathy syndrome: eleven new cases and a review of 51 previously published cases. J Neuroophthalmol 2001; 21: 173-187
    CrossrefPubMedGoogle Scholar