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Horm Metab Res 2015; 47(01): 31-35
DOI: 10.1055/s-0034-1395518
Review
© Georg Thieme Verlag KG Stuttgart · New York

Xenotransplantation of Porcine Islet Cells as a Potential Option for the Treatment of Type 1 Diabetes in the Future

B. Reichart
1   Institute for Surgical Research at the Walter-Brendel-Centre for Experimental Medicine, Ludwig-Maximilians-University, Munich, Germany
,
H. Niemann
2   Friedrich-Loeffler-Institute Mariensee, Federal Research Institute for Animal Health, Neustadt, Germany
,
T. Chavakis
3   Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany
4   Centre for Diabetes Research, Paul Langerhans Institute Dresden, Dresden, Germany
5   Department of Clinical Pathobiochemistry, Technische Universität Dresden, Dresden, Germany
6   Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany
,
J. Denner
7   Robert-Koch-Institute, Berlin, Germany
,
E. Jaeckel
8   Medical School of Hannover, Department Gastroenterology, Hepatology, Endocrinology, Diabetology, Hannover, Germany
,
B. Ludwig
3   Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany
4   Centre for Diabetes Research, Paul Langerhans Institute Dresden, Dresden, Germany
9   Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany
,
G. Marckmann
10   Institute for Ethics, History and Theory of Medicine, Ludwig-Maximilians-University, Munich, Germany
,
A. Schnieke
11   Chair of Livestock Biotechnology, Technical University of Munich, Freising, Germany
,
R. Schwinzer
12   Transplant Laboratory, Clinic for General,- Visceral-, and Transplantation Surgery, Hannover Medical School, Hannover, Germany
,
J. Seissler
13   Medizinische Klinik und Poliklinik IV, Diabetes Zentrum, Ludwig-Maximilians-University, Munich, Germany
,
R. R. Tönjes
14   Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, Langen, Germany
,
N. Klymiuk
15   Gene Center, Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-University, Munich, Germany
,
E. Wolf
15   Gene Center, Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-University, Munich, Germany
,
S. R. Bornstein
3   Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany
4   Centre for Diabetes Research, Paul Langerhans Institute Dresden, Dresden, Germany
9   Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany
16   Department of Endocrinology and Diabetes, King’s College, London, England
› Author Affiliations
Further Information

Publication History

received 23 September 2014

accepted 20 October 2014

Publication Date:
15 December 2014 (online)

Also available at
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Abstract

Solid organ and cell transplantation, including pancreatic islets constitute the treatment of choice for chronic terminal diseases. However, the clinical use of allogeneic transplantation is limited by the growing shortage of human organs. This has prompted us to initiate a unique multi-center and multi-team effort to promote translational research in xenotransplantation to bring xenotransplantation to the clinical setting. Supported by the German Research Foundation, an interdisciplinary group of surgeons, internal medicine doctors, diabetologists, material sciences experts, immunologists, cell biologists, virologists, veterinarians, and geneticists have established a collaborative research center (CRC) focusing on the biology of xenogeneic cell, tissue, and organ transplantation. A major strength of this consortium is the inclusion of members of the regulatory bodies, including the Paul-Ehrlich Institute (PEI), infection specialists from the Robert Koch Institute and PEI, veterinarians from the German Primate Center, and representatives of influential ethical and religious institutions. A major goal of this consortium is to promote islet xenotransplantation, based on the extensive expertise and experience of the existing clinical islet transplantation program. Besides comprehensive approaches to understand and prevent inflammation-mediated islet xenotransplant dysfunction [immediate blood-mediated inflammatory reaction (IBMIR)], we also take advantage of the availability of and experience with islet macroencapsulation, with the goal to improve graft survival and function. This consortium harbors a unique group of scientists with complementary expertise under a cohesive program aiming at developing new therapeutic approaches for islet replacement and solid organ xenotransplantation.

Key words

diabetes mellitus type 1 - xenotransplantation - islet cells
 

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