Fortschr Neurol Psychiatr 2012; 80(2): 72-78
DOI: 10.1055/s-0031-1273428
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Versorgungswege von erstmanifesten psychotischen Patienten – eine Übersicht internationaler Studien

Pathways-to-Care for First-Episode Psychotic Patients – An Overview of International StudiesN. Schaffner1 , B. G. Schimmelmann1 , A. Niedersteberg2 , F. Schultze-Lutter1
  • 1Kinder- und Jugendpsychiatrie, Forschungsabteilung, Universitäre Psychiatrische Dienste (UPD), Bern, Schweiz
  • 2Suchthilfezentrum Nikolausberg, Caritasverband Duisburg e. V.
Further Information

Publication History

Publication Date:
07 July 2011 (online)

Zusammenfassung

Eine längere Dauer der unbehandelten Psychose (DUP) und der unbehandelten Erkrankung (DUI) ist mit einem negativen Krankheitsverlauf von Psychosen assoziiert. Daher gibt es zunehmend Bemühungen, die DUP zu verkürzen und Betroffene frühzeitig einer adäquaten Therapie zuzuführen. Um frühe Hindernisse bei der Hilfesuche abzubauen, müssen diese zunächst identifiziert werden. Daher wird eine Übersicht initialer Hilfesuchkontakte und über Prädiktoren von Behandlungsverzögerungen bei psychotischen Erstmanifestationen gegeben. Die DUP weist über alle 25 identifizierten Studien eine ungünstige Länge von gut einem Jahr auf, wobei es im Vorfeld im Mittel zu drei Kontakten vor der Behandlungsaufnahme kam. Da Hindernisse in den Versorgungswegen auf allen relevanten Ebenen (Patient, Umwelt und Versorgungssystem) identifiziert wurden, liegen Optimierungsmöglichkeiten in der Vernetzung der Anlaufstellen und kontinuierlicher Aufklärungsarbeit der Bevölkerung und medizinisch-psychologischer Fachkräften.

Abstract

A longer duration of untreated psychosis (DUP) as well as of untreated illness (DUI) was found to be associated with a negative course of psychosis. Thus, increasing efforts are made to reduce the DUP and provide adequate treatment as early as possible. But, in order to overcome obstacles to early help-seeking, these have to be identified first. Thus, an overview on initial help-seeking behaviour and predictors of DUP is given. Across 25 identified studies, the DUP, at about one year on average, is still unfavourably long and includes on average of three help-seeking contacts prior to the initiation of adequate treatment. Since negative factors in pathways-to-care involve features on all relevant levels (patient, social environment and health-care system), an optimisation of pathways-to-care will require the integration of services and continuous awareness programmes targeting the general population and mental health-care professionals.

Literatur

  • 1 WHO, World Health Organiation .Prevention of Mental Disorder. Effective interventions an policy options. Genf: WHO; 2004
  • 2 Marshall M, Lewis S, Lockwood A et al. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systemativ review.  Arch Gen Psychiatry. 2005;  62 975-983
  • 3 Schimmelmann B G, Huber C G, Lampert M et al. Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort.  J Psychiatr Res. 2008;  42 982-990
  • 4 Singh S P, Grange T. Measuring pathways to care in first-episode psychosis: A systematic review.  Schizophr Res. 2006;  81 75-82
  • 5 Wang P S, Angermeyer M, Borges G et al. Delay and failure in treatment seeking after first onset of mental disorders in the World Health Organizations World Mental Health Survey Initiative.  World Psychiatry. 2007;  6 177-118
  • 6 Rogler L H, Cortes D E. Help-Seeking pathways: a unifying concept in mental health care.  Am J Psychiatry. 1993;  150 554-561
  • 7 Lindert J, Schouler-Ocak M, Heinz A et al. Mental health, health care utilisation of migrants in Europe.  Eur Psychiatry. 2008;  23 14-20
  • 8 Eisenberg D, Golberstein E, Gollust S E. Help-Seeking and Access to Mental Health Care in a University Student Population.  Med Care. 2007;  45 594-601
  • 9 Compton M T, Esterberg M L, Druss B G et al. A descriptive study of pathways to care among hospitalized urban African American first-episode schizophrenia-spectrum patients.  Soc Psychiatry Psychiatr Epidemiol. 2006;  41 566-573
  • 10 Zachrisson H D, Rödje K, Mykletun A. Utilization of health services in relation to mental health problems in adolescents: A population based survey.  BMC Public Health. 2006;  6 34
  • 11 Amaddeo F, Zambello F, Tansanella M et al. Accessibility and pathways to psychiatric care in a community-based mental health system.  Soc Psychiatry Psychiat Epidemiol. 2001;  36 500-507
  • 12 Andrade L H, Vianna M C, Tofoli L FF et al. Influence of psychiatric morbidity and sociodemografic determinants on use of service in a catchment area in the city of Sao Paolo, Brazil.  Soc Psychiatry Psychiatr Epidemiol. 2008;  43 45-51
  • 13 Gater R, Goldberg D. Pathways to Psychiatric Care in South Manchester.  Br J Psychiatry. 1991;  159 90-96
  • 14 Gater R, Jordanova V, Maric N et al. Pathways to psychiatric care in Eastern Europe.  Br J Psychiatry. 2005;  186 529-535
  • 15 McMiller W P, Weisz J R. Help-Seeking Preceding Mental Health Clinic Intake among African-American, Latino and Caucasian Youths.  J Am Acad Child Adolesc Psychiatry. 1996;  35 8
  • 16 Rickwood D J, Deane F P, Wilson C J. When and how do young people seek professional help for mental health problems?.  MJA. 2007;  187 35-39
  • 17 Steel Z, McDonald R, Silove D et al. Pathways to the first contact with specialist mental health care.  Aust N Z J Psychiatry. 2006;  40 347-354
  • 18 Addington J, Mastrigt van S, Hutchinson J et al. Pathways to care: help seeking behaviour in first episode psychosis.  Acta Psychiatr Scand. 2002;  106 358-364
  • 19 Archie S, Akthar-Danesch N, Norman R et al. Ethnic Diversity and Pathways to Care for a First Episode of Psychosis in Ontario.  Schizophr Bull. 2008;  DOI: 10.1093 /schbul/sbn137
  • 20 Bechard-Evans L, Schmitz N, Abadi S et al. Determinants of help-seeking and system related components of delay in the treatment of first-episode psychosis.  Schizophr Res. 2007;  96 206-214
  • 21 Boydell K M, Gladstone B M, Volpe T. Understanding Help Seeking Delay in the prodrom to First episode Psychosis: A Secondary Analysis of the Perspectives of Young People.  Psychiatr Rehabil J. 2006;  30 54-60
  • 22 Burnett R, Mallet R, Bhugra D et al. The first contact of patients with schizophrenia with psychiatric services: social factors and pathways to care in a multi-ethnic population.  Psychol Med. 1999;  29 475-483
  • 23 Chong S A, Mythily S, Verma S. Reducing the duration of untreated psychosis and changing help-seeking behaviour in Singapore.  Soc Psychiatry Psychiatr Epidemiol. 2005;  40 619-621
  • 24 Chong S A, Mythily S, Lum A et al. Determinations of duration of untreated psychosis and the pathway to care in Singapore.  Int Journal Soc Psychiatry. 2005;  51 55-62
  • 25 Cole E, Leavy G, King M et al. Pathways to Care for Patients with a First Episode of Psychosis. A Comparison of Ethnic Groups.  Br J Psychiatry. 1995;  167 770-776
  • 26 Cougnard A, Kalmi E, Desage A et al. Pathways to care of first-admitted subjects with psychosis in South-Western-France.  Psychol Med. 2004;  34 267-276
  • 27 Etheridge K, Yarrow L, Peet M. Pathways to care in first-episode psychosis.  J Psychiatr Ment Health Nurs. 2004;  11 125-128
  • 28 Fuchs J, Steinert T. Inanspruchnahme professioneller Hilfe, Einweisungswege und Dauer der unbehandelten Psychose bei erstmals stationär aufgenommenen Patienten.  Fortschr Neurol Psychiatr. 2002;  70 40-45
  • 29 Fuchs J, Steinert T. Patients with first episode of schizophrenia spectrum psychosis and their pathways to psychiatric hospital care in South Germany.  Soc Psychiatry Psychiatr Epidemiol. 2004;  39 375-380
  • 30 Jablensky A, Sartorius N, Ernberg G et al. Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organisation Ten-Country Study.  Psychol Med Monogr Suppl. 1992;  22 1092
  • 31 Joa I, Johannsessen J O, Auestad B et al. The key to reducing duration of untreated first psychosis: information campaigns.  Schizophr Bull. 2008;  34 472-466
  • 32 Johnstone E C, Crow T J, Johnson A L et al. The Northwick Park Study of first episodes of schizophrenia. I. Presentation of the illness and problems relating to admission.  Br J Psychiatry. 1986;  148 115-120
  • 33 Johnstone E C, MacMillian J, Crow T et al. The Northwick Park first episodes of schizophrenia. III. Short-term outcome in trial entrants and trial eligible patients.  Br J Psychiatry. 1986;  148 128-133
  • 34 Köhn D, Pukrop R, Niedersteberg A et al. Wege in die Behandlung: Hilfesuchverhalten schizophrener Ersterkrankter.  Fortschr Neurol Psychiatr. 2004;  72 1-8
  • 35 Larsen T K, Johannessen J O, Opjordsmoen S. First episode schizophrenia with long duration of untreated psychosis.  Br J Psychiatry. 1998;  172 (Suppl 33) 45-52
  • 36 Lincoln C, Harrigan S, McGorry P D. Understanding the topografy of the early psychosis pathway.  Br J Psychiatry. 1998;  172 (Suppl 33) 21-25
  • 37 Morgan C, Mallett R, Hutchinson G et al. Pathways to care and ethnicity. 1: Sample characteristics and compulsory admission.  Br J Psychiatry. 2005;  186 281-289
  • 38 Morgan C, Mallett R, Hutchinson G et al. Pathways to care and ethnicity. 2: Source of referral and help-seeking.  Br J Psychiatry. 2005;  186 290-296
  • 39 Naqvi H A, Hussain S, Zaman M et al. Duration of untreated Psychosis form Karachi, Pakistan.  Plos One. 2009;  4 e7409
  • 40 Norman R M, Malla A K, Verdi M B et al. Understanding delay in treatment for first-episode psychosis.  Psychol Med. 2004;  34 255-266
  • 41 Norman R M, Malla A K, Manchanda R. Delay in treatment for psychosis.  Soc Psychiatry Psychiatr Epidemiol. 2007;  42 507-512
  • 42 O’Callaghan E, Turner N, Renwick L et al. First episode psychosis and the trail to secondary care: help-seeking and health-system delays.  Soc Psychiatry Psychiatr Epidemiol. 2010;  45 381-391
  • 43 Pek E, Mythily S, Chong S A. Clinical and Social Correlates of Duration of Untreated Psychosis in First-episode Psychosis Patients.  Ann Acad Med Singapore. 2006;  35 24-26
  • 44 Platz C, Umbricht D S, Cattapan-Ludewig K et al. Help-seeking pathways in early psychosis.  Soc Psychiatry Psychiatr Epidemiol. 2006;  41 967-974
  • 45 Skeate A, Jackson C, Birchwood M et al. Duration of untreated psychosis and pathways to care in first-episode psychosis.  Br J Psychiatry. 2002;  181 (Suppl 43) 73-77
  • 46 Turner M, Smith-Hamel C, Mulder R. Pathways to care in a New Zeeland first-episode of psychosis cohort.  Aust N Z J Psychiatry. 2006;  40 421-428
  • 47 Temmingh H S, Oosthuizen P P. Pathways to care and treatment delays in first and multi episodes psychosis.  Soc Psychiatry Psychiatr Epidemiol. 2008;  43 727-735
  • 48 Wong D FK. Uncovering sociocultural factors influencing the pathway to care of Chinese caregivers with relatives suffering from early psychosis in Hong Kong.  Cult Med Psychiatry. 2007;  31 51-71
  • 49 Yamazawa R, Mizuno M, Nemoto T et al. Duration of untreated psychosis and pathways to psychiatric services in first-episode schizophrenia.  Psychiatry Clin Neurosci. 2004;  58 76-81
  • 50 Cremer H, Pestieau P. Social insurance competition between Bismarck and Beveridge.  Journal of Urban Economics. 2003;  54 181-196
  • 51 Johannessen J O, Larsen T K, Joa I et al. Pathways to care for first-episode psychosis in early detection healthcare sector.  Br J Psychiatry. 2005;  187 (Suppl 48) 24-28
  • 52 Häfner H, Riecher A, Maurer K et al. Ein Instrument zur retrospektiven Einschätzung des Erkrankungsbeginns bei Schizophrenie (IRAOS) – Entwicklung und erste Ergebnisse.  Zt Klin Psychol. 1990;  19 230-255
  • 53 Köhn D, Niedersteberg A, Wieneke A et al. Frühverlauf schizophrener Ersterkrankungen mit langer Dauer der unbehandelten Erkrankung.  Fortschr Neurol Psychiatr. 2004;  72 88-92
  • 54 Kiliç C, Rezaki M, Ustun T B et al. Pathways to psychiatric care in Ankara.  Social Psychiatry Psychiatr Epidemiol. 1994;  29 131-136
  • 55 Chen E YH, Dunn E LW, Miao M YK et al. The impact of family experience on the duration of untreated psychosis (DUP) in Hong Kong.  Soc Psychiatry Psychiatr Epidemiol. 2005;  40 350-356
  • 56 Kessler R C, Berglund P A, Bruce M L et al. The Prevalence and Correlates of Untreated Serious Mental Illness.  Health Serv Res. 2001;  36(6 Pt 1) 1009-1017
  • 57 Jorm A F, Christensen H, Griffith K M. The public’s ability to recognize mental disorders and their beliefs about treatment: changes in Australia over 8 years.  Aust N Z J Psychiatry. 2006;  40 36-41
  • 58 Angel R, Throits P. The impact of culture on the cognitive structure of illness.  Cult Med Psychiatry. 1987;  11 465-494
  • 59 Fink P J, Tasman A. Stigma and Mental Illness. 1. Aufl Washington DC: American Psychiatric Press; 1992
  • 60 Steele L, Dewa C, Lee K. Socioeconomic Status and Self-Reported Barriers to Mental Health Service Use.  Can J Psychiatry. 2007;  52 201-206
  • 61 Lincoln C V, McGorry P D. Who cares? Pathways to care in early psychosis.  Psychiatr Serv. 1995;  46 1166-1171
  • 62 Simon A E, Lauber C, Ludewig K et al. Swiss Early Psychosis Project. General practitioners and schizophrenia: results from a Swiss survey.  Br J Psychiatry. 2005;  187 274-281
  • 63 Simon A E, Roth B, Zmilacher S et al. Developing services for the early detection of psychosis: a critical consideration of the current state of the art.  Eur Child Adolesc Psychiatry. 2007;  16 96-103
  • 64 Strakowski S M, Tohen M, Stoll A L et al. Comorbidity in Psychosis at First Hospitalization.  Am J Psychiatry. 1993;  150 752-757
  • 65 Strakowski S M, Keck P E, McElroy S L et al. Chronology of comorbid and principal syndromes in first-episode psychosis.  Compr Psychiatr. 1995;  36 106-112
  • 66 Becker I. Komorbidität im Frühverlauf von Psychosen. Dissertation an der Medizinischen Fakultät der Universität zu Köln; 2007
  • 67 Klosterkötter J, Hellmich M, Schultze-Lutter F. Ist die Diagnose schizophrener Störungen schon in der initialen Prodromalphase vor der psychotischen Erstmanifestation möglich?.  Fortschr Neurol Psychiatr. 2000;  68 (Sonderheft 1) 13-21
  • 68 Rosen J L, Miller T J, D’Andrea J T et al. Comorbid diagnoses in patients meeting criteria for the schizophrenia prodrome.  Schizophr Res. 2006;  85 124-31
  • 69 Salokangas R KR, Luutonen S, Nieminen M et al. Vulnerability to psychosis increases the risk of depression. Results from the RADEP study.  Nord J Psychiatry. 2007;  61 393-402
  • 70 Svirskis T, Korkeila J, Heinimaa M et al. Axis-I disorders and vulnerability to psychosis.  Schizophr Res. 2005;  75 439-446
  • 71 Schultze-Lutter F, Ruhrmann S, Picker H et al. The distinction between depressive and early psychotic symptoms.  Br J Psychiatry. 2007;  191 (Suppl 51) 31-37
  • 72 Helgason L. Twenty years’ follow-up of first psychiatric presentation for schizophrenia: what could have been prevented?.  Acta Psychiatr Scand. 1990;  81 231-235
  • 73 McGorry P D, Edwards J, Mihalopoulos C et al. EPPIC: an evolving system of early detection and optimal management.  Schizophr Bull. 1996;  22 305-326
  • 74 Klosterkötter J, Schultze-Lutter F. Gibt es eine Primärprävention schizophrener Psychosen?.  Fortschr Neurol Psychiat. 2001;  69 (Sonderheft 2) S104-S112

Dr. Frauke Schultze-Lutter

Kinder- und Jugendpsychiatrie, Forschungsabteilung, Universitäre Psychiatrische Dienste (UPD)

Bolligenstr. 111

3000 Bern 60

Schweiz

Email: frauke.schultze-lutter@kjp.unibe.ch

>