Antifungal Triterpene Glycosides from the Sea Cucumber Bohadschia marmorata

 

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Abstract

Four new holostan-type triterpene glycosides, marmoratoside A (1), 17α-hydroxy impatienside A (2), marmoratoside B (3), 25-acetoxy bivittoside D (4), together with two known triterpene glycosides, impatienside A (5) and bivittoside D (6), were isolated from the sea cucumber Bohadschia marmorata Jaeger. On the basis of spectroscopic analyses, including two-dimensional NMR techniques, and chemical reactions, the structures of the new triterpene glycosides were elucidated. Compounds 1, 2, 5, and 6 exhibited significant antifungal activity against six strains (0.70 ≤ MIC₈₀ ≤ 2.81 μM).

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Dr. Yang-Hua Yi

Research Center for Marine Drugs

School of Pharmacy

Second Military Medical University

325 Guohe Road

Shanghai 200433

People’s Republic of China

Phone: +86-2165-384-988

Fax: +86-2165-483-662

Email: yiyanghua@hotmail.com