Exp Clin Endocrinol Diabetes 2021; 129(S 01): S82-S90
DOI: 10.1055/a-1284-6412
German Diabetes Association: Clinical Practice Guidelines

Diabetic Foot Syndrome

Stephan Morbach
1   Department of Diabetology and Angiology, Marienkrankenhaus gGmbH, Soest, Germany
,
Ralf Lobmann
2   Department of Endocrinology, Diabetology and Geriatrics, Klinikum Stuttgart, Bad Cannstatt, Germany
,
Michael Eckhard
3   University Diabetes Center and Interdisciplinary Diabetic Foot Center of Central Hesse, University Hospital Giessen and Marburg GmbH, Giessen site and GZW Diabetes Clinic Bad Nauheim, Germany
,
Eckhard Müller
4   Practice for Diabetology and Nephrology, KfH kidney center, Bernkastel-Kues, Germany
,
Heinrich Reike
5   Department of Internal Medicine, Mariannen-Hospital, Werl, Germany
,
Alexander Risse
6   Diabetes Center, Department of Internal Medicine North, Dortmund, Germany
,
Gerhard Rümenapf
7   Upper Rhine Vascular Center, Department of Vascular Surgery, Diakonissen Stiftungs Hospital, Speyer, Germany
,
Maximilian Spraul
8   Diabetes Center Rheine, Department of Internal Medicine III (Mathias Hospital and Jacobi Hospital), Rheine, Germany
› Author Affiliations

Definition

Diabetic foot syndrome is understood to be all pathological changes in the foot of a person with diabetes mellitus. These include pre-ulcerous lesions such as abnormal corneal callouses. Ulcers or necroses usually develop as a result of repetitive trauma with limited sensation of pressure and pain in the context of diabetic polyneuropathy (e. g. in the form of high pressure and shear stress, especially in foot and toe deformities). In Germany, more than 50% of all cases are characterized by a relevant peripheral arterial occlusive disease (PAOD), whose symptoms (claudication, pain at rest) are often masked by the polyneuropathy.



Publication History

Article published online:
22 December 2020

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  • References

  • 1 Claessen H, Narres M, Haastert H. et al. Lower-extremity amputations in people with and without diabetes in Germany, 2008-2012 - an analysis of more than 30 million inhabitants. Clin Epidemiol 2018; 10: 475-488
  • 2 Fedorko L, Bowen JM, Jones W. et al. Hyperbaric oxygen therapy does not reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb: A prospective, double-blind, randomized controlled clinical trial. Diabetes Care 2016; 39: 392-399
  • 3 Santema KTB, Stoekenbroek RM, Koelemay MJW. et al. Hyperbaric oxygen therapy in the treatment of ischemic lower-extremity ulcers in patients with diabetes: Results of the DAMO2CLES Multicenter Randomized Clinical Trial. Diabetes Care 2018; 41: 112-119
  • 4 Schaper NC. Diabetic foot ulcer classification system for research purposes: A progress report on criteria for including patients in research studies. Diabetes Metab Res Rev 2004; 20: S90-S95
  • 5 Lipsky BA, Berendt AR, Deery HG. et al. Diagnosis and treatment of diabetic foot infections. Clin Infect Dis 2004; 39: 885-910
  • 6 Edmonds M, Lázaro-Martínez JL, Alfayate-García JM. et al. Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): An international, multicentre, doubleblind, randomised, controlled trial. Lancet Diabetes Endocrinol 2018; 6: 186-196
  • 7 Game F, Jeffcoate W, Tarnow L. et al. LeucoPatch system for the management of hard-to-heal diabetic foot ulcers in the UK, Denmark, and Sweden: An observer-masked, randomised controlled trial. Lancet Diabetes Endocrinol 2018; 11: 870-878
  • 8 Lavery LA, Fulmer J, Shebetka KA. et al. The efficacy and safety of Grafix (®) for the treatment of chronic diabetic foot ulcers: Results of a multicentre, controlled, randomised, blinded, clinical trial. Int Wound J 2014; 5: 554-560
  • 9 THE 2019 IWGDF GUIDELINES https://iwgdfguidelines.org/guidelines/guidelines/
  • 10 Final report of the G-BA on vacuum therapy in DFS December 2019 www.g-ba.de/downloads/2019-12-19_MVV-RL_Vacuum sealing therapy
  • 11 Lawall H, Huppert P, Espinola-Klein C. et al. Clinical practice guideline - the diagnosis and treatment of peripheral arteial diasese. Dtsch Arztebl Int 2016; 113: 729-736
  • 12 Koller A, Metzger C, Möller M. et al. Shoe care and risk classes for diabetic foot syndrome. OST Special Issue Diabetes 2005. Orthopaedics Shoe Technology 2005; 45-47