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Erschienen in: Wiener klinische Wochenschrift 17-18/2018

30.07.2018 | original article

Predictors of colonic pathologies in active acromegaly: single tertiary center experience

verfasst von: Raim Iliaz, M.D., Sema Ciftci Dogansen, Seher Tanrikulu, Gulsah Yenidunya Yalin, Bilger Cavus, Mine Gulluoglu, Filiz Akyuz, Sema Yarman

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 17-18/2018

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Summary

Background

Regarding the incidence of colorectal malignancy and polyps in patients with acromegaly, studies reported different results in different populations. For this reason, the aim of this study was to determine the frequency of possible colonic pathologies, such as diverticula, polyps, and malignancies in Turkish patients with active acromegaly and factors affecting them.

Methods

A total of 134 patients with acromegaly and 134 patients with irritable bowel syndrome/dyspeptic symptoms as a control group were included in the study. None of these patients had a previous or family history of colonic neoplasms. Colonoscopies of patients with acromegaly were performed before definitive surgery in a single center by experienced endoscopists.

Results

The acromegaly and control groups were similar in terms of age and sex. The incidence of all colonic polyps was significantly higher in the acromegaly group (p = 0.012). The frequency of hyperplastic polyps was also increased in the acromegaly group (p = 0.004); however, the frequencies of adenomatous polyps and colonic diverticula were similar in both groups. In the comparison of patients with acromegaly for the presence of polyps, those with polyps were older, had higher levels of insulin-like growth factor (IGF-1), were of male sex, and skin tags were more common (p = 0.016, p = 0.034, p = 0.006 and p = 0.001, respectively). There were no colorectal malignancies in the patients with active acromegaly.

Conclusion

The frequency of hyperplastic polyps was increased, whereas colonic malignancy was not observed in Turkish patients with active acromegaly.
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Metadaten
Titel
Predictors of colonic pathologies in active acromegaly: single tertiary center experience
verfasst von
Raim Iliaz, M.D.
Sema Ciftci Dogansen
Seher Tanrikulu
Gulsah Yenidunya Yalin
Bilger Cavus
Mine Gulluoglu
Filiz Akyuz
Sema Yarman
Publikationsdatum
30.07.2018
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 17-18/2018
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-018-1367-3

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