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Erschienen in: Wiener klinische Wochenschrift 9-10/2016

01.05.2016 | original article

Pre-therapeutic fibrinogen levels are of prognostic significance in locally advanced head and neck cancer

verfasst von: Edgar Selzer, MD, Anja Grah, Gregor Heiduschka, Gabriela Kornek, Dietmar Thurnher

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 9-10/2016

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Summary

Objectives

The objective of this retrospective study was to clarify the potential prognostic significance of pre-therapeutic fibrinogen levels in head and neck squamous cell carcinoma (HNSCC) patients treated with curative intent by primary radiotherapy (RT) or with postoperative radiotherapy (PORT).

Patients and methods

We retrospectively analyzed data from 347 patients with histologically confirmed locally advanced HNSCC. Analysis was conducted separately for the patient collective treated with PORT (N = 141; 85.1 % AJCC stage III/IV) and for patients treated with primary RT (N = 206; 97.1 % AJCC stage III/IV). Kaplan Meier analyses as well as univariate and multivariate survival analyses were performed to identify factors associated with overall survival (OS).

Results

The most relevant observation was that plasma fibrinogen levels were significantly associated with a reduction of overall survival rates. In the low-fibrinogen (below 411 mg/dL) postoperatively irradiated group, OS rates at 2 and 3 years were 86 and 83 %, and in the high-fibrinogen group 66 and 51 %, respectively. In the RT group with low fibrinogen levels, OS rates after 2 and 3 years were 74 and 53 %, and in the high-fibrinogen group 40 and 22 %, respectively. In multivariate analysis, elevated fibrinogen concentrations were associated with inferior OS in both the postoperatively (HR = 2.5; p = 0.001) as well as in the primarily irradiated (HR = 1.7; p = 0.003) group.

Conclusions

We conclude from these results that elevated pre-therapeutic fibrinogen may serve as a biomarker associated with worsened prognosis in locally advanced head and neck cancer patients treated by either RT or surgery followed by adjuvant radiotherapy.
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Metadaten
Titel
Pre-therapeutic fibrinogen levels are of prognostic significance in locally advanced head and neck cancer
verfasst von
Edgar Selzer, MD
Anja Grah
Gregor Heiduschka
Gabriela Kornek
Dietmar Thurnher
Publikationsdatum
01.05.2016
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 9-10/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-016-0963-3

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