Pilonidal sinus disease: a 25-year experience and long-term results of different surgical techniques

The preferences of surgical approach in the therapy of pilonidal sinus disease differ slightly between surgeons and countries. A recent meta-analysis showed that recurrence rates depend on surgical approach and follow-up time [1]. The impact of geographical factors such as genetic mechanisms responsible for hair growth and hair thickness, healthcare settings, and socioeconomic factors on recurrence rates are revealed in the retrospective study, suggesting that some approaches have extraordinarily good outcomes in specific countries; however, flap techniques remain superior [2]. Postoperative complications and recurrence significantly impair the quality of life of patients, especially when symptoms are severe. In decades past, excision with primary midline closure or lay open were considered the gold standard; however, these methods are associated with high complication and recurrence rates. In many cases, management can be challenging owing to the number of previous failed operations. In addition, when nonhealing or extended perianal wounds after excisional surgery occur, technical modifications of the subsequent flap procedure need to be done. According to the recently published German guidelines, excision with midline closure should not be performed at all [3].

With better understanding of the etiology of the disease, there is a shift toward more successful treatment concepts. Bascom showed that early epidermal changes are amplified by further deep tissue disruption from moisture, anerobic conditions, hair, and bacteria [4]. Remarkably, in the analysis of hair samples from pilonidal sinus cavities, short hair fragments with rootless sharp cut ends were found [5]. Furthermore, testing of hair from three different body regions suggests that occipital hair is regularly present in pilonidal sinus nests [6]. To improve outcomes, the origin of the disease must be understood. Differential diagnoses such as anal fistula can be excluded by magnetic resonance imaging [7], and more successful methods should be applied. These methods should include strategies to reshape and flatten the gluteal cleft and relocate the incision off the midline. Surprisingly, certain limitations and acceptance of newer techniques appear to impact the choice of the method.

We were interested in differences between surgical groups in regard to recurrence rates and wound care complications. We hypothesized that risk factors such as previous pilonidal operations, abscess incisions, duration of disease, smoking status, and body mass index (BMI) are associated with higher recurrence rates as well as with a higher incidence of wound care complications.

This study was designed as a retrospective single-center cohort study and conducted at the University Clinic of General Surgery of the Medical University of Vienna. All patients gave informed consent. The Ethics Committee of the Medical University of Vienna approved the study (EC reference: 2019/2020).

A total of 382 patients underwent surgery for pilonidal sinus disease at the University Clinic of General Surgery of the Medical University of Vienna in the period between November 1994 and May 2019. After exclusion of 83 patients (Fig. 1), 299 patients were assessed for eligibility. A fraction of the excluded patients with emergency surgery (n = 22) involves those who received either an abscess incision and definitive treatment (4 excisions with lay open and 5 excisions with marsupialization) or an abscess incision and drainage in the operating room (n = 13). The vast majority of our acute cases were managed at the outpatient ward. Among operations for chronic pilonidal disease, 61 excisions with primary midline closure, 108 excisions with marsupialization, 65 Karydakis flap procedures, 49 Dufourmentel flaps, and 16 Bascom I procedures were performed. The percentage breakdown of applied techniques is shown in Fig. 2.

The preferences in choice of technique evolved over the investigated time period. Excisional surgeries were in a leading position until 2007. In 2003, for the first time, a flap technique, in particular the Dufourmentel flap, was adopted. Later, between 2008 and 2011, this was the most frequently performed procedure. The first off-midline procedure, namely the Karydakis flap, was carried out in 2008 and has been on the rise since 2012. A minimally invasive Bascom I procedure did not find broader use, except for in 2016. A graphical display of yearly spectra of performed techniques is shown in Fig. 3.

The analyzed patient population demonstrated a representation of mostly younger males, whilst the proportion of patients younger than 30 years varied between 55.4 and 72.1% among the cohorts. There was no significant difference in median BMI between the five treatment arms, which ranged from 24.8 to 27.5 kg/m². However, in the Karydakis flap subgroup, 47.7% of patients had overweight and 27.7% had obesity. Furthermore, all groups consisted of 60.0% or more smokers. With the exception of the Karydakis flap group, there were relatively high rates of abscess incisions in patient history taking, with values from 62.3% for excision with marsupialization to 75.0% for the Bascom I procedure. The highest median disease duration was seen in flap groups, with 36 (6;444) months for Karydakis flap and 36 (1;180) months for Dufourmentel flap. The Dufourmentel flap subgroup also demonstrated the highest fraction of patients with previous operations, with 51% of patients having had one or more failed pilonidal procedure. Baseline characteristics of chronic cases are summarized in Table 1.

Our retrospective study compared five different surgical approaches in the therapy of pilonidal disease in terms of recurrence rates and wound care complications. Recurrence rates vary between different methods depending on follow-up time. We found out that previous failed pilonidal operations are an independent prognostic factor for recurrence and development of wound complications.

We identified the following limitations in our study: not all techniques were included in the study, as certain procedures were used only on rare occasions. Although the group size of the most recent technique is still small, we included this group for explorative purposes and to give the most complete overview of all applied techniques. Information on disease recurrence was retrieved in some patients through recall during telephone interview, which may be another source of bias. Patients may not be able to recall accurately, and certain details may be omitted. To minimize this bias, we created a standardized scheme for conducting calls.

Finally, it is important to consider that an essential component of high-quality studies, which enables comparison of results of different surgical groups, is a universally adopted and well-recognized classification of the disease [9].

To date, many studies have reported outstanding results using off-midline methods for both primary and recurrent pilonidal disease [10‐14]. Importantly, two decades ago, the deep, moist, and bacteria-friendly gluteal cleft with anerobic conditions was recognized by Bascom as the primary source of surgical failure [4]. Therefore, flattening of the natal cleft and bringing the incision off midline play a crucial role in the management of the disease. Although radical excision was earlier considered as a goal of treatment [15], it now can no longer be advocated. This paradigm shift represents a pivotal change for the choice of treatment strategy. Opponents of flap techniques often highlight their own subjective positive experience with excisional procedures. The reasons for the resistance to change could be comfort with the status quo and temporary incompetence caused by a shallow learning curve when learning without an experienced mentor. In our study, the group of excision with primary midline closure demonstrated the second highest recurrence rate 60 months postoperatively and the highest wound complication rate, at 24.7% and 46.3%, respectively. When comparing 24-month follow-up and the last follow-up at 268 months, the recurrence rates vary between 10.5 and 71.8%. Excisional methods do not address the deep gluteal cleft and when they fail, patients end up with a distorted gluteal cleft and nonhealing wounds, which is likely to have a profoundly negative impact on further treatment. A retrospective study on 124 patients with recurrent pilonidal disease comparing two treatment arms, namely excisional method and Karydakis flap, showed a 43% 1‑year recurrence rate in the first group and 3% in the second group (p < 0.0001) [9]. Consequently, patients with recurrent pilonidal disease would have the most to gain from off-midline procedures. Comparing our two flap groups, the Dufourmentel flap demonstrated similar recurrence rates to the Karadykis flap at 24 and 60 months. The meta-analysis by Stauffer compared different techniques in 89,583 patients and demonstrated that advancement flaps (Karydakis and Bascom cleft lift) and rhomboid flaps (Limberg and Dufourmentel) have comparable results with respect to recurrence rate [1]. They reported 0.6% at 24 months for advancement flaps and 1.8% at 24 months for rhomboid flaps. The evidence suggests that a modified version of the Limberg flap, where a caudal pole is placed 1–2 cm laterally to the midline, should be preferred over the classical one [16, 17]. A survey analyzing 92 certified institutions in Switzerland and Austria revealed that among flap techniques, in 70.7% a Limberg flap and in only 17.2% a modified Limberg flap was performed (advancement flaps were analyzed separately as an off-midline group) [18]. We experienced a considerably high overall wound care complication rate (39.1%) and the highest rate of severe wound care complications (7.8%) in the Karydakis flap group. In most cases, wound dehiscence in caudal, cranial, or both portions occurred. After taking a closer look, we found out that the overall complication rate was as high as 46.9% until 2017 (23 out of 49 patients) and decreased to 13% in the period between 2018 and 2019 (2 out of 15 patients). The Karydakis flap group (n = 65) consisted of 63.1% smokers and 75.4% patients with overweight or obesity. The evidence demonstrated that risk factors such as smoking and BMI > 25.0 kg/m² are associated with higher rates of wound care complications in patients with pilonidal disease [11, 19, 20]. One of the key principles of construction of advancement flaps is complete wound lateralization. If the final suture line or its caudal portion ends up in the midline, some additional skin needs to be excised [12, 21, 22]. Although, the minimally invasive procedures are associated with higher recurrence rates, their benefits are well known. From a cost standpoint, they are time efficient, usually require no hospital stay, and do not significantly disrupt patients’ activities. In our analysis, we had only 16 Bascom I operations. No conclusions can be drawn due to this small number of patients. This group showed the highest recurrence rate at 24 and 60 months, at 30 and 65%, respectively. The retrospective study by Gips on 1358 patients demonstrated a recurrence rate of 6.5% at 1 year and 13.2% at 10 years postoperatively; mean time to recurrence was 2.7 years [23]. A German retrospective study on 153 patients reported a recurrence rate of 28% at 24 months postoperatively and median time interval to recurrence of 2.8 months [24]. Their study also revealed a significant predictive value of disease duration > 6 months and BMI > 25.0 kg/m² for development of recurrence [23]. Similar results were reported in the study by Bascom, with mean time to complete healing of 3 weeks [25]. The last investigated group, excision with marsupialization showed a recurrence rate as high as 13.7% at 24 months, 18.1% at 60 months, and an overall wound care complication rate of 23.9%. Two of the major concerns in this method are prolonged healing and significant postoperative pain.

To achieve better results, we need to deliver the right treatment at the right time. The emphasis should be given to adoption of techniques with high success rates. In order to improve surgical outcomes, it is imperative to respect the key principles of their construction. Well-designed prospective studies focusing on both treatment strategies—minimally invasive techniques as well as flap procedures—are necessary.