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Erschienen in: European Surgery 5/2020

16.04.2020 | original article

Phthalates and infertility: an issue in hernia meshes?

verfasst von: Nele Van De Winkel, Yagmur Yurtkap, Vicky Dhooghe, Shengyun Huang, Govindan Malarvannan, Guy Van den Mooter, Adrian Covaci, Ann Van Schepdael, Marc Miserez

Erschienen in: European Surgery | Ausgabe 5/2020

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Summary

Background

Based on recent data that sperm motility in humans might be (temporarily) affected when lightweight meshes are used for laparoscopic inguinal hernia repair, the aim of this study was to identify the plasticizers present in meshes used for hernia repair.

Methods

Mesh samples (n = 13) were cut into small pieces (1 cm × 1 cm), and, after the addition of internal standard, plasticizers were extracted with hexane:acetone (1:1; v:v) by vortex and ultrasonication. The analysis was performed by gas chromatography and mass spectrometry (GC-MS) in electron ionization mode (EI) with full scan acquisition. The identification of compounds was done by injection of reference standards and using the Wiley mass spectral library.

Results

None of the targeted plasticizers, including phthalates, were present in the analyzed mesh samples. In particular, di-(2-ethylhexyl) phthalate (DEHP), a major phthalate plasticizer frequently used in medical devices in the past, was not detected in any of the samples.

Conclusion

The implantation of mesh materials affecting male fertility, whether temporarily or not, cannot be explained by the presence of the targeted plasticizers, since none of them were found in the wide range of commonly used meshes that were tested in our study.
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Metadaten
Titel
Phthalates and infertility: an issue in hernia meshes?
verfasst von
Nele Van De Winkel
Yagmur Yurtkap
Vicky Dhooghe
Shengyun Huang
Govindan Malarvannan
Guy Van den Mooter
Adrian Covaci
Ann Van Schepdael
Marc Miserez
Publikationsdatum
16.04.2020
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 5/2020
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-020-00636-1