Skip to main content
Erschienen in: Journal für Urologie und Urogynäkologie/Österreich 2/2020

27.05.2020 | Originalien

Peniskarzinom

verfasst von: Dr. Klaus Eredics, PD Dr. Stephan Seklehner, PD Dr. Martin Marszalek

Erschienen in: Journal für Urologie und Urogynäkologie/Österreich | Ausgabe 2/2020

Einloggen, um Zugang zu erhalten

Zusammenfassung

Beim Peniskarzinom handelt es sich fast immer um ein aggressives Plattenepithelkarzinom, welches typischerweise an der Glans oder am inneren Vorhautblatt entsteht. Es stellt aufgrund seiner geringen Inzidenz von 1/100.000 Männern in Europa eine Besonderheit im klinisch-urologischen Alltag dar. Im Jahre 2015 wurden in Österreich nur 65 Peniskarzinome neu diagnostiziert. Aufgrund der Seltenheit dieser Erkrankung und der damit verbundenen Problematik in Diagnostik und Therapie wurde die Behandlung des Peniskarzinoms in mehreren Ländern zentralisiert.
Literatur
1.
Zurück zum Zitat Hakenberg OW, Compérat EM, Minhas S, Necchi A, Protzel C, Watkin N (2015) EAU guidelines on penile cancer: 2014 update. Eur Urol 67(1):142–150PubMedCrossRef Hakenberg OW, Compérat EM, Minhas S, Necchi A, Protzel C, Watkin N (2015) EAU guidelines on penile cancer: 2014 update. Eur Urol 67(1):142–150PubMedCrossRef
2.
Zurück zum Zitat Madsen BS, van den Brule AJ, Jensen HL, Wohlfahrt J, Frisch M (2008) Risk factors for squamous cell carcinoma of the penis—population-based case-control study in Denmark. Cancer Epidemiol Biomarkers Prev 17(10):2683–2691PubMedCrossRef Madsen BS, van den Brule AJ, Jensen HL, Wohlfahrt J, Frisch M (2008) Risk factors for squamous cell carcinoma of the penis—population-based case-control study in Denmark. Cancer Epidemiol Biomarkers Prev 17(10):2683–2691PubMedCrossRef
3.
Zurück zum Zitat Maden C, Sherman KJ, Beckmann AM, Hislop TG, Teh CZ, Ashley RL, Daling JR (1993) History of circumcision, medical conditions, and sexual activity and risk of penile cancer. J Natl Cancer Inst 85(1):19–24PubMedCrossRef Maden C, Sherman KJ, Beckmann AM, Hislop TG, Teh CZ, Ashley RL, Daling JR (1993) History of circumcision, medical conditions, and sexual activity and risk of penile cancer. J Natl Cancer Inst 85(1):19–24PubMedCrossRef
4.
Zurück zum Zitat Parkin DM, Bray F (2006) Chapter 2: The burden of HPV-related cancers. Vaccine 24(Suppl 3):11–25CrossRef Parkin DM, Bray F (2006) Chapter 2: The burden of HPV-related cancers. Vaccine 24(Suppl 3):11–25CrossRef
5.
Zurück zum Zitat Rubin MA, Kleter B, Zhou M, Ayala G, Cubilla AL, Quint WG, Pirog EC (2001) Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis. Am J Pathol 159(4):1211–1218PubMedPubMedCentralCrossRef Rubin MA, Kleter B, Zhou M, Ayala G, Cubilla AL, Quint WG, Pirog EC (2001) Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis. Am J Pathol 159(4):1211–1218PubMedPubMedCentralCrossRef
7.
Zurück zum Zitat Kirnbauer R, Booy F, Cheng N, Lowy DR, Schiller JT (1992) Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc Natl Acad Sci USA 89(24):12180–12184PubMedCrossRef Kirnbauer R, Booy F, Cheng N, Lowy DR, Schiller JT (1992) Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc Natl Acad Sci USA 89(24):12180–12184PubMedCrossRef
8.
Zurück zum Zitat Castellsague X, Giuliano AR, Goldstone S, Guevara A, Mogensen O, Palefsky JM, Group T, Shields C, Liu K, Maansson R et al (2015) Immunogenicity and safety of the 9‑valent HPV vaccine in men. Vaccine 33(48):6892–6901PubMedCrossRef Castellsague X, Giuliano AR, Goldstone S, Guevara A, Mogensen O, Palefsky JM, Group T, Shields C, Liu K, Maansson R et al (2015) Immunogenicity and safety of the 9‑valent HPV vaccine in men. Vaccine 33(48):6892–6901PubMedCrossRef
10.
Zurück zum Zitat Castellsagué X, Muñoz N, Pitisuttithum P, Ferris D, Monsonego J, Ault K, Luna J, Myers E, Mallary S, Bautista OM et al (2011) End-of-study safety, immunogenicity, and efficacy of quadrivalent HPV (types 6, 11, 16, 18) recombinant vaccine in adult women 24–45 years of age. Br J Cancer 105(1):28–37PubMedPubMedCentralCrossRef Castellsagué X, Muñoz N, Pitisuttithum P, Ferris D, Monsonego J, Ault K, Luna J, Myers E, Mallary S, Bautista OM et al (2011) End-of-study safety, immunogenicity, and efficacy of quadrivalent HPV (types 6, 11, 16, 18) recombinant vaccine in adult women 24–45 years of age. Br J Cancer 105(1):28–37PubMedPubMedCentralCrossRef
11.
Zurück zum Zitat Gottlieb J, Higley C, Sosnowski R, Bjurlin MA (2016) Smoking-related genitourinary cancers: a global call to action in smoking cessation. Rev Urol 18(4):194–204PubMedPubMedCentral Gottlieb J, Higley C, Sosnowski R, Bjurlin MA (2016) Smoking-related genitourinary cancers: a global call to action in smoking cessation. Rev Urol 18(4):194–204PubMedPubMedCentral
12.
Zurück zum Zitat Daling JR, Madeleine MM, Johnson LG, Schwartz SM, Shera KA, Wurscher MA, Carter JJ, Porter PL, Galloway DA, McDougall JK et al (2005) Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. Int J Cancer 116(4):606–616PubMedCrossRef Daling JR, Madeleine MM, Johnson LG, Schwartz SM, Shera KA, Wurscher MA, Carter JJ, Porter PL, Galloway DA, McDougall JK et al (2005) Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. Int J Cancer 116(4):606–616PubMedCrossRef
13.
Zurück zum Zitat Stern RS (1990) Genital tumors among men with psoriasis exposed to psoralens and ultraviolet A radiation (PUVA) and ultraviolet B radiation. The photochemotherapy follow-up study. N Engl J Med 322(16):1093–1097PubMedCrossRef Stern RS (1990) Genital tumors among men with psoriasis exposed to psoralens and ultraviolet A radiation (PUVA) and ultraviolet B radiation. The photochemotherapy follow-up study. N Engl J Med 322(16):1093–1097PubMedCrossRef
14.
Zurück zum Zitat Visser O, Adolfsson J, Rossi S, Verne J, Gatta G, Maffezzini M, Franks KN, The RARECARE working group (2012) Incidence and survival of rare urogenital cancers in Europe. Eur J Cancer 48(4):456–464PubMedCrossRef Visser O, Adolfsson J, Rossi S, Verne J, Gatta G, Maffezzini M, Franks KN, The RARECARE working group (2012) Incidence and survival of rare urogenital cancers in Europe. Eur J Cancer 48(4):456–464PubMedCrossRef
15.
Zurück zum Zitat Bray F, Ferlay J, Laversanne M, Brewster DH, Gombe Mbalawa C, Kohler B, Piñeros M, Steliarova-Foucher E, Swaminathan R, Antoni S et al (2015) Cancer incidence in five continents: inclusion criteria, highlights from volume X and the global status of cancer registration. Int J Cancer 137(9):2060–2071PubMedCrossRef Bray F, Ferlay J, Laversanne M, Brewster DH, Gombe Mbalawa C, Kohler B, Piñeros M, Steliarova-Foucher E, Swaminathan R, Antoni S et al (2015) Cancer incidence in five continents: inclusion criteria, highlights from volume X and the global status of cancer registration. Int J Cancer 137(9):2060–2071PubMedCrossRef
16.
Zurück zum Zitat Backes DM, Kurman RJ, Pimenta JM, Smith JS (2009) Systematic review of human papillomavirus prevalence in invasive penile cancer. Cancer Causes Control 20(4):449–457PubMedCrossRef Backes DM, Kurman RJ, Pimenta JM, Smith JS (2009) Systematic review of human papillomavirus prevalence in invasive penile cancer. Cancer Causes Control 20(4):449–457PubMedCrossRef
17.
Zurück zum Zitat Chaux A, Netto GJ, Rodriguez IM, Barreto JE, Oertell J, Ocampos S, Boggino H, Codas R, Xavier Bosch F, de Sanjose S et al (2013) Epidemiologic profile, sexual history, pathologic features, and human papillomavirus status of 103 patients with penile carcinoma. World J Urol 31(4):861–867PubMedCrossRef Chaux A, Netto GJ, Rodriguez IM, Barreto JE, Oertell J, Ocampos S, Boggino H, Codas R, Xavier Bosch F, de Sanjose S et al (2013) Epidemiologic profile, sexual history, pathologic features, and human papillomavirus status of 103 patients with penile carcinoma. World J Urol 31(4):861–867PubMedCrossRef
18.
Zurück zum Zitat Verhoeven RH, Janssen-Heijnen ML, Saum KU, Zanetti R, Caldarella A, Holleczek B, Brewster DH, Hakulinen T, Horenblas S, Brenner H et al (2013) Population-based survival of penile cancer patients in Europe and the United States of America: no improvement since 1990. Eur J Cancer 49(6):1414–1421CrossRefPubMed Verhoeven RH, Janssen-Heijnen ML, Saum KU, Zanetti R, Caldarella A, Holleczek B, Brewster DH, Hakulinen T, Horenblas S, Brenner H et al (2013) Population-based survival of penile cancer patients in Europe and the United States of America: no improvement since 1990. Eur J Cancer 49(6):1414–1421CrossRefPubMed
19.
Zurück zum Zitat Trama A, Foschi R, Larranaga N, Sant M, Fuentes-Raspall R, Serraino D, Tavilla A, Van Eycken L, Nicolai N, EUROCARE‑5 Working Group (2015) Survival of male genital cancers (prostate, testis and penis) in Europe 1999–2007: results from the EUROCARE‑5 study. Eur J Cancer 51(15):2206–2216PubMedCrossRef Trama A, Foschi R, Larranaga N, Sant M, Fuentes-Raspall R, Serraino D, Tavilla A, Van Eycken L, Nicolai N, EUROCARE‑5 Working Group (2015) Survival of male genital cancers (prostate, testis and penis) in Europe 1999–2007: results from the EUROCARE‑5 study. Eur J Cancer 51(15):2206–2216PubMedCrossRef
20.
Zurück zum Zitat Dechev IY, Banchev AV, Mateva NG (2005) Epidemiology, diagnostic and therapeutic problems for carcinoma of the penis in the regions of Plovdiv, Pazardzhik and Smolyan between 1993 and 2002. Folia Med 47(3–4):33–39 Dechev IY, Banchev AV, Mateva NG (2005) Epidemiology, diagnostic and therapeutic problems for carcinoma of the penis in the regions of Plovdiv, Pazardzhik and Smolyan between 1993 and 2002. Folia Med 47(3–4):33–39
21.
Zurück zum Zitat Jakobsen JK, Krarup KP, Kirrander P, Håkansson U, Kaipia A, Perttila I, Axcrona K, Torkelsen TK, Hilmarsson R, Jensen JB et al (2016) Penile cancer in Scandinavia: current practice and future perspectives. Scand J Urol 50(1):90–92PubMedCrossRef Jakobsen JK, Krarup KP, Kirrander P, Håkansson U, Kaipia A, Perttila I, Axcrona K, Torkelsen TK, Hilmarsson R, Jensen JB et al (2016) Penile cancer in Scandinavia: current practice and future perspectives. Scand J Urol 50(1):90–92PubMedCrossRef
22.
Zurück zum Zitat Djajadiningrat RS, Graafland NM, van Werkhoven E, Meinhardt W, Bex A, van der Poel HG, van Boven HH, Valdés Olmos RA, Horenblas S (2014) Contemporary management of regional nodes in penile cancer-improvement of survival? J Urol 191(1):68–73PubMedCrossRef Djajadiningrat RS, Graafland NM, van Werkhoven E, Meinhardt W, Bex A, van der Poel HG, van Boven HH, Valdés Olmos RA, Horenblas S (2014) Contemporary management of regional nodes in penile cancer-improvement of survival? J Urol 191(1):68–73PubMedCrossRef
23.
Zurück zum Zitat Bayles AC, Sethia KK (2010) The impact of Improving Outcomes Guidance on the management and outcomes of patients with carcinoma of the penis. Ann R Coll Surg Engl 92(1):44–45PubMedPubMedCentralCrossRef Bayles AC, Sethia KK (2010) The impact of Improving Outcomes Guidance on the management and outcomes of patients with carcinoma of the penis. Ann R Coll Surg Engl 92(1):44–45PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Veeratterapillay R, Teo L, Asterling S, Greene D (2015) Oncologic outcomes of penile cancer treatment at a UK supraregional center. Urology 85(5):1097–1103PubMedCrossRef Veeratterapillay R, Teo L, Asterling S, Greene D (2015) Oncologic outcomes of penile cancer treatment at a UK supraregional center. Urology 85(5):1097–1103PubMedCrossRef
26.
Zurück zum Zitat Heins MJ, de Jong JD, Spronk I, Ho VKY, Brink M, Korevaar JC (2017) Adherence to cancer treatment guidelines: influence of general and cancer—specific guideline characteristics. Eur J Public Health 27(4):616–620PubMed Heins MJ, de Jong JD, Spronk I, Ho VKY, Brink M, Korevaar JC (2017) Adherence to cancer treatment guidelines: influence of general and cancer—specific guideline characteristics. Eur J Public Health 27(4):616–620PubMed
27.
Zurück zum Zitat Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud PA, Rubin HR (1999) Why don’t physicians follow clinical practice guidelines? A framework for improvement. JAMA 282(15):1458–1465PubMedCrossRef Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud PA, Rubin HR (1999) Why don’t physicians follow clinical practice guidelines? A framework for improvement. JAMA 282(15):1458–1465PubMedCrossRef
28.
Zurück zum Zitat Rieken M, Djajadiningrat RS, Kluth LA, Favaretto RL, Xylinas E, Guimaraes GC, Soares FA, Kent M, Sjoberg DD, Horenblas S et al (2014) Predictors of cancer-specific mortality after disease recurrence in patients with squamous cell carcinoma of the penis. Eur Urol 66(5):811–814PubMedCrossRef Rieken M, Djajadiningrat RS, Kluth LA, Favaretto RL, Xylinas E, Guimaraes GC, Soares FA, Kent M, Sjoberg DD, Horenblas S et al (2014) Predictors of cancer-specific mortality after disease recurrence in patients with squamous cell carcinoma of the penis. Eur Urol 66(5):811–814PubMedCrossRef
29.
Zurück zum Zitat Kieffer JM, Djajadiningrat RS, van Muilekom EA, Graafland NM, Horenblas S, Aaronson NK (2014) Quality of life for patients treated for penile cancer. J Urol 192(4):1105–1110PubMedCrossRef Kieffer JM, Djajadiningrat RS, van Muilekom EA, Graafland NM, Horenblas S, Aaronson NK (2014) Quality of life for patients treated for penile cancer. J Urol 192(4):1105–1110PubMedCrossRef
30.
Zurück zum Zitat Klaassen Z, Jen RP, DiBianco JM, Reinstatler L, Li Q, Madi R, Lewis RW, Smith AM, Neal DE Jr, Moses KA et al (2015) Factors associated with suicide in patients with genitourinary malignancies. Cancer 121(11):1864–1872PubMedCrossRef Klaassen Z, Jen RP, DiBianco JM, Reinstatler L, Li Q, Madi R, Lewis RW, Smith AM, Neal DE Jr, Moses KA et al (2015) Factors associated with suicide in patients with genitourinary malignancies. Cancer 121(11):1864–1872PubMedCrossRef
31.
Zurück zum Zitat Simpson WG, Klaassen Z, Jen RP, Hughes WM 5th, Neal DE Jr, Terris MK (2018) Analysis of suicide risk in patients with penile cancer and review of the literature. Clin Genitourin Cancer 16(2):e257–e261PubMedCrossRef Simpson WG, Klaassen Z, Jen RP, Hughes WM 5th, Neal DE Jr, Terris MK (2018) Analysis of suicide risk in patients with penile cancer and review of the literature. Clin Genitourin Cancer 16(2):e257–e261PubMedCrossRef
32.
Zurück zum Zitat Cindolo L, Spiess PE, Bada M, Chipollini JJ, Nyirady P, Chiodini P, Varga J, Ditonno P, Battaglia M, De Nunzio C et al (2018) Adherence to EAU guidelines on penile cancer translates into better outcomes: a multicenter international study. World J Urol 37(8):1649–1657PubMedCrossRef Cindolo L, Spiess PE, Bada M, Chipollini JJ, Nyirady P, Chiodini P, Varga J, Ditonno P, Battaglia M, De Nunzio C et al (2018) Adherence to EAU guidelines on penile cancer translates into better outcomes: a multicenter international study. World J Urol 37(8):1649–1657PubMedCrossRef
33.
Zurück zum Zitat Albersen M, Parnham A, Joniau S, Sahdev V, Christodoulidou M, Castiglione F, Nigam R, Malone P, Freeman A, Jameson C et al (2018) Predictive factors for local recurrence after glansectomy and neoglans reconstruction for penile squamous cell carcinoma. Urol Oncol 36(4):141–146PubMedCrossRef Albersen M, Parnham A, Joniau S, Sahdev V, Christodoulidou M, Castiglione F, Nigam R, Malone P, Freeman A, Jameson C et al (2018) Predictive factors for local recurrence after glansectomy and neoglans reconstruction for penile squamous cell carcinoma. Urol Oncol 36(4):141–146PubMedCrossRef
34.
Zurück zum Zitat Horenblas S (2001) Lymphadenectomy for squamous cell carcinoma of the penis. Part 2: the role and technique of lymph node dissection. BJU Int 88(5):473–483PubMedCrossRef Horenblas S (2001) Lymphadenectomy for squamous cell carcinoma of the penis. Part 2: the role and technique of lymph node dissection. BJU Int 88(5):473–483PubMedCrossRef
35.
Zurück zum Zitat Kirrander P, Sherif A, Friedrich B, Lambe M, Håkansson U (2016) Swedish National Penile Cancer Register: incidence, tumour characteristics, management and survival. BJU Int 117(2):287–292PubMedCrossRef Kirrander P, Sherif A, Friedrich B, Lambe M, Håkansson U (2016) Swedish National Penile Cancer Register: incidence, tumour characteristics, management and survival. BJU Int 117(2):287–292PubMedCrossRef
36.
Zurück zum Zitat Jakobsen JK, Jensen JB (2016) DaPeCa-2: implementation of fast-track clinical pathways for penile cancer shortens waiting time and accelerates the diagnostic process—a comparative before-and-after study in a tertiary referral centre in Denmark. Scand J Urol 50(1):80–87PubMedCrossRef Jakobsen JK, Jensen JB (2016) DaPeCa-2: implementation of fast-track clinical pathways for penile cancer shortens waiting time and accelerates the diagnostic process—a comparative before-and-after study in a tertiary referral centre in Denmark. Scand J Urol 50(1):80–87PubMedCrossRef
38.
Zurück zum Zitat Spiess PE, Hernandez MS, Pettaway CA (2009) Contemporary inguinal lymph node dissection: minimizing complications. World J Urol 27(2):205–212PubMedCrossRef Spiess PE, Hernandez MS, Pettaway CA (2009) Contemporary inguinal lymph node dissection: minimizing complications. World J Urol 27(2):205–212PubMedCrossRef
Metadaten
Titel
Peniskarzinom
verfasst von
Dr. Klaus Eredics
PD Dr. Stephan Seklehner
PD Dr. Martin Marszalek
Publikationsdatum
27.05.2020
Verlag
Springer Vienna
Erschienen in
Journal für Urologie und Urogynäkologie/Österreich / Ausgabe 2/2020
Print ISSN: 1023-6090
Elektronische ISSN: 1680-9424
DOI
https://doi.org/10.1007/s41972-020-00106-6

Weitere Artikel der Ausgabe 2/2020

Journal für Urologie und Urogynäkologie/Österreich 2/2020 Zur Ausgabe