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Erschienen in: memo - Magazine of European Medical Oncology 4/2020

04.06.2020 | short review

Particle therapy in head and neck cancer—expanding therapeutic options

verfasst von: MD, PhD Petra Georg

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 4/2020

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Summary

The management of head and neck tumors is challenging and requires a multidisciplinary approach. Besides the common histology of squamous cell cancer, other histologies like adenoid cystic carcinoma, mucosal melanoma, and adenocarcinoma are often present. These tumors are radioresistant and need high radiation doses. Photon beam therapy is often limited by the normal tissue tolerance, and particle therapy using protons or carbon ions is a valuable treatment option. Due to their dosimetric advantages, protons enable deposition of high tumor doses, while optimally sparing the surrounding tissue. Carbon ions offer the additional advantage of a higher linear energy transfer (LET) which results in a higher biological effectiveness of tumor cell damage. Therefore, while protons can also be used in sterilizing microscopic disease, carbon ions should be considered in large macroscopic disease, where a significant tumor burden has to be managed.
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Metadaten
Titel
Particle therapy in head and neck cancer—expanding therapeutic options
verfasst von
MD, PhD Petra Georg
Publikationsdatum
04.06.2020
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 4/2020
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-020-00623-y