Introduction
Materials and methods
Measurements
Statistical analysis
Results
Comparison between T1DM and the general population
Parameter | T1DM—mean (SD) | General population (SD) | P-Value |
---|---|---|---|
Age (years)
| 45 (15) | 45–49 (10) | ns |
<30 years: N (%) | 32 (17.2) | 2456 (15.6) | ns |
30–49 years: N (%) | 79 (42.5) | 6034 (38.3) | |
50–69 years: N (%) | 65 (34.9) | 5697 (36.1) | |
>70 y: N (%) | 10 (5.4) | 1584 (10) | |
Sex m:f (%)
| 51:49 | 44:56 | ns |
BMI (kg/m
2
)
| 25.9 (4.19) | 25.3 (4.5) | 0.027 |
<25 kg/m2: N (%) | 86 (46) | 8383 (53.2) | ns |
25–<30 kg/m2: N (%) | 74 (39.8) | 5218 (33.1) | |
≥30 kg/m2: N (%) | 26 (14) | 2170 (13.8) | |
BMI by age groups
| |||
<30 years (kg/m2) | 23.7 (4.0) | 23.3 (4.0) | ns |
30–49 years (kg/m2) | 26.7 (4.4) | 24.8 (4.3) | <0.001 |
50–69 years (kg/m2) | 26.1 (3.8) | 26.4 (4.5) | ns |
>70 years (kg/m2) | 25.6 (3.0) | 26.4 (4.1) | ns |
Metabolic parameters in T1DM
Variables | BMI | P-value | |
---|---|---|---|
<27.5 kg/m2 | ≥27.5 kg/m2 | ||
Women: N (%) | 65 (50.8) | 26 (44.8) | ns |
Diabetes duration (years) | 18.6 ± 12.7 | 20.8 ± 12.5 | ns |
Age (years) | 44 ± 16 | 47 ± 13 | ns |
HbA1c (%/mmol/mol) | 7.7 ± 1.4/61 ± 15 | 7.8 ± 1.1/62 ± 12 | ns |
HbA1c >7.5% (58 mmol/mol): N (%) | 63 (49.2) | 35 (60.3) | ns |
Arterial hypertension: N (%) | 72 (60) | 46 (82.1) | 0.004 |
Systolic BP (mm Hg) | 133.2 ± 17.9 | 143.2 (21.7) | 0.001 |
Diastolic BP (mm Hg) | 80.0 ± 9.1 | 85.2 ± 12.8 | 0.002 |
Basal insulin dose (IU) | 20.1 ± 10 | 30.3 ± 11.4 | <0.001 |
Insulin (IU/m2/d) | 10.9 ± 5.1 | 14.4 ± 5.1 | <0.001 |
Insulin (IU/kg/d) | 0.28 ± 0.13 | 0.33 ± 0.12 | 0.017 |
Creatinine (mg/dl) | 0.9 ± 0.9 | 0.9 ± 0.2 | ns |
Dyslipidemia: N (%) | 18 (16.1) | 19 (40.4) | 0.002 |
Triglyceride (mg/dl) | 90.8 ± 45.3 | 120.6 ± 53.2 | <0.001 |
Cholesterol (mg/dl) | 182.6 ± 37 | 173.8 ± 37.1 | ns |
HDL (mg/dl) | 69.5 ± 20.6 | 56.1 ± 13.8 | <0.001 |
LDL (mg/dl) | 92.3 ± 33.1 | 82.9 ± 22.6 | ns |
Non-HDL-cholesterol (mg/dl) | 113.2 ± 36.9 | 118.3 ± 37.8 | ns |
Albuminuria: N (%) | 7 (7.8) | 12 (30) | 0.001 |
Microalbuminuria (%) | 5 (5.6) | 10 (25) | 0.003 |
Macroalbuminuria (%) | 2 (2.2) | 2 (5) | ns |