Introduction
Patients and methods
Results
Patient characteristics
Variable | Peripartal ICU admission | All | Test | |
---|---|---|---|---|
Study group | Historical group | |||
Mean ± SD
N (%) | Mean ± SD
N (%) | Mean ± SD
N (%) |
p value | |
Participants | 135 (56.7) | 103 (43.3) | 238 (100) | n. t. |
Age at delivery (years) | 31.6 ± 6.4 | 29.3 ± 5.8 | 30.6 ± 6.3 | 0.005 |
Parity | ||||
Primiparae | 78 (57.8) | 60 (58.3) | 138 (58) | n. s. |
Multiparae | 57 (42.2) | 43 (41.7) | 100 (42) | n. s. |
Multiple pregnancya
| 17 (12.6) | 6 (5.8) | 23 (9.7) | n. s. |
Assisted reproduction | 16 (6.8) | n/a | n/a | n. t. |
Multiple comorbiditiesb
| 37 (27.4) | 12 (11.7) | 49 (20.6) | 0.003 |
Pre-existing condition | ||||
Yes | 63 (46.6) | 20 (19.4) | 83 (34.9) | <0.001 |
No | 72 (53.4) | 83 (80.6) | 155 (65.1) | |
Pre-existing condition (detail) | ||||
Hypertension | 12 (8.9) | 3 (2.9) | 15 (6.3) | n. s. |
Diabetes | 8 (5.9) | 4 (3.9) | 12 (5) | n. s. |
Bronchial asthma | 3 (2.2) | 1 (1) | 4 (1.7) | n. s. |
Congenital heart disease | 13 (9.6) | 2 (1.9) | 15 (6.3) | 0.012 |
Rheumatic disease | 7 (5.2) | 3 (2.9) | 10 (4.2) | n. s. |
Opioid dependence | 7 (5.2) | 1 (1) | 8 (3.4) | n. t. |
Othersc
| 13 (9.6) | 6 (5.8) | 19 (8) | n. s. |
Obstetric outcomes
Variable | Category | Study group (N = 135) | Historical group (N = 103) | All (N = 238) | Test |
---|---|---|---|---|---|
Unit | Mean ± SD % (N) | Mean ± SD % (N) | Mean ± SD % (N) |
p value | |
Pregnancy outcome | Live birth Stillbirth | 123 (91.1) 12 (8.9) | 83 (80.6) 20 (19.4) | 206 (86.6) 32 (13.4) | 0.018 |
Prematurity | Preterm delivery No preterm delivery | 119 (88.2) 16 (11.8) | 75 (72.8) 28 (27.2) | 194 (81.5) 44 (18.5) | 0.003 |
Antenatal referral | Antenatal referral No antenatal referral | 31 (23) 104 (77) | 40 (38.8) 63 (61.2) | 71 (29.8) 167 (70.2) | 0.008 |
Mode of delivery | Vaginal deliverya
Cesarean section Instrumental delivery | 9 (6.7) 124 (91.9) 2 (1.4) | 23 (22.3) 77 (74.8) 3 (2.9) | 32 (13.4) 201 (84.5) 5 (2.1) | 0.001 |
Gestational age at delivery | Weeks | 31.5 ± 5.5 | 31.8 ± 7.1 | 31.6 ± 6.2 | n. s. |
<24+0 24+0–27+6 28+0–33+6 34+0–36+6 ≥37+0 | 8 (5.9) 15 (11.1) 48 (35.6) 48 (35.6) 16 (11.8) | 11 (10.7) 12 (11.7) 20 (19.4) 32 (31) 28 (27.2) | 19 (8) 27 (11.3) 68 (28.6) 80 (33.6) 44 (18.5) | n. t. | |
Birthweightb
| Grams | 1897 ± 880 | 2215 ± 1055 | 2021 ± 963 | 0.019 |
<500 g 500–999 g 1000–1499 g 1500–2499 g ≥2500 g | 6/154 (3.9) 25/154 (16.2) 24/154 (15.6) 46/154 (29.9) 42/154 (27.3) | 6/109 (5.5) 11/109 (10.1) 7/109 (6.4) 21/109 (19.3) 46/109 (42.2) | 12/263 (4.6) 36/263 (13.7) 31/263 (11.8) 67/263 (25.5) 88/263 (33.5) | n. t. | |
Time of ICU admission | Antepartum Postpartum | 18 (13.3) 117 (86.7) | 35 (34) 68 (66) | 53 (22.3) 185 (77.7) | <0.001 |
Hysterectomy | Hysterectomy No hysterectomy | 13 (9.6) 122 (90.4) | 17 (16.5) 86 (83.5) | 30 (12.6) 208 (87.4) | n. s. |
Treatment details
Variable | Category | Study group (N = 135) | Historical group (N = 103) | All (N = 238) | Test |
---|---|---|---|---|---|
Unit | Median (IQR) % (N) | Median (IQR) % (N) | Median (IQR) % (N) |
p value | |
Obstetric anesthesia | Spinal Epidural General None | 77 (57) 7 (5.2) 48 (35.6) 3 (2.2) | 24 (23.3) 6 (5.8) 56 (54.4) 17 (16.5) | 101 (42.4) 13 (5.5) 104 (43.7) 20 (8.4) | <0.001 |
Monitoring | Non-invasive Invasive blood pressure Pulmonary artery pressure | 106 (78.5) 21 (15.6) 8 (5.9) | 37 (35.9) 51 (49.5) 15 (14.6) | 143 (60) 72 (30.3) 23 (9.7) | <0.001 |
Ventilationb
| Days | 3 (1–10) | 1 (1–10) | 2 (1–10) | n. s. |
Ventilation >7 days Ventilation <7 days No ventilation | 9 (6.7) 23 (17) 103 (76.3) | 16 (15.5) 33 (32) 54 (52.5) | 25 (10.5) 56 (23.5) 157 (66) | n. t. | |
ICU outcome | Recovered Near miss Death | 69 (51.2) 60 (44.4) 6 (4.4) | 38 (36.9) 59 (57.3) 6 (5.8) | 107 (45) 119 (50) 12 (5) | n. s. |
Intervention | ECa
PC FFP Antibiotics Antihypertensive Catecholamine LMWH intravenously HF/HD CPR ECMO | 45 (33.3) 11 (8.1) 15 (11.1) 85 (63) 63 (46.7) 21 (15.6) 8 (5.9) 2 (1.5) 7 (5.2) 6 (4.4) | 56 (54.4) 21 (20.4) 3 (2.9) 80 (77.7) 25 (24.3) 28 (27.2) 11 (10.7) 12 (11.7) 8 (7.8) 4 (3.9) | 101 (42.4) 32 (13.4) 18 (7.6) 165 (69.3) 88 (37) 49 (20.6) 19 (8) 14 (5.9) 15 (6.3) 10 (4.2) | 0.001 0.006 0.018 0.015 0.002 0.028 n. s. 0.001 n. s. n. s. |
Primary organ failure | Cardiovascular/respiratory Renal Cerebral Hepatic Not specified | 74 (54.8) 10 (7.4) 5 (3.7) 13 (9.6) 33 (24.5) | 77 (74.8) 4 (3.9) 2 (1.9) 4 (3.9) 16 (15.5) | 151 (63.4) 14 (5.9) 7 (2.9) 17 (7.2) 49 (20.6) | 0.045 |
Length of stay | Days at ICU Total duration | 3 (1–4) 13 (10–18) | 3 (1–7) 12 (9–22) | 3 (1–5) 13 (9–20) | 0.02 |
n. s. |