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Erschienen in: Wiener klinische Wochenschrift 23-24/2016

01.12.2016 | original article

Orosomucoid is an independent predictor of prognosis in chronic heart failure

verfasst von: Petra Kaplan, MD, Prof. Dr. Bojan Vrtovec, MD PhD, Assist. Prof. Borut Jug, MD PhD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 23-24/2016

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Summary

Background

Heart failure is associated with low-grade inflammation. In the present study we sought to assess the prognostic impact of orosomucoid, a marker of inflammation, in outpatients with heart failure.

Methods

In outpatients with chronic heart failure (no change in clinical status and/or therapy >3 months prior to inclusion), baseline levels of orosomucoid were determined. Clinical follow-up was obtained and the rate of heart failure-related deaths and hospitalisations recorded.

Results

A total of 134 patients (median age 71, 33.3 % female, mean left ventricular ejection fraction [LVEF] 36 %) were included. During a median follow-up of 695 (456–811) days, 54 patients (40.1 %) experienced an event. On Cox multivariate analysis, orosomucoid levels above the median (>497 mg/l) emerged as an independent predictor of prognosis (hazard ratio = 2.86, 95 % confidence interval 1.48–5.52 after adjusting for age, gender, ischaemic vs. non-ischaemic aetiology, LVEF, NT-proBNP and NYHA class).

Conclusion

Orosomucoid levels are an independent predictor of heart failure-related mortality and hospitalisations in patients with chronic heart failure.
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Metadaten
Titel
Orosomucoid is an independent predictor of prognosis in chronic heart failure
verfasst von
Petra Kaplan, MD
Prof. Dr. Bojan Vrtovec, MD PhD
Assist. Prof. Borut Jug, MD PhD
Publikationsdatum
01.12.2016
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 23-24/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-016-1034-5

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