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Erschienen in: Wiener klinisches Magazin 5/2018

06.09.2018 | Intensivmedizin

Organersatz in der Zukunft

Grenzen und Perspektiven

verfasst von: Prof. Dr. Reimer Riessen, Prof. Dr. Uwe Janssens, Prof. Dr. Stefan John, Prof. Dr. Christian Karagiannidis, Prof. Dr. Stefan Kluge

Erschienen in: Wiener klinisches Magazin | Ausgabe 5/2018

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Zusammenfassung

Zur Behandlung des schwersten Lungenversagens und des kardiogenen Schocks werden im letzten Jahrzehnt zunehmend extrakorporale Organersatzverfahren (ECMO) eingesetzt, auch wenn die zugrunde liegende wissenschaftliche Evidenz immer noch gering ist und die Verfahren trotz aller technischer Verbesserungen weiterhin ein hohes Komplikationsrisiko aufweisen. Die Selektion der Patienten, die von einem solchen Organersatzverfahren am wahrscheinlichsten profitieren, stellt daher für Intensivmediziner und die anderen beteiligten Fachdisziplinen immer noch eine große Herausforderung dar. Neben dem Schweregrad des akuten Organversagens sollten hier die Ätiologie und Behandlungsmöglichkeiten der Grunderkrankung, die Komorbiditäten und der funktionelle Status des Patienten vom interdisziplinären Behandlungsteam umfassend evaluiert werden. Dabei sind auch ethische Herausforderungen zu bewältigen. Aufgrund der Komplexität der Verfahren und der hohen organisatorischen Anforderungen ist es sinnvoll, ECMO-Therapien in dafür besonders qualifizierten Zentren zu konzentrieren und eine umfassende wissenschaftliche Auswertung der Behandlungsdaten zu fördern.
Literatur
2.
Zurück zum Zitat Bein T, Brodie D (2017) Understanding ethical decisions for patients on extracorporeal life support. Intensive Care Med 43:1510–1511CrossRef Bein T, Brodie D (2017) Understanding ethical decisions for patients on extracorporeal life support. Intensive Care Med 43:1510–1511CrossRef
3.
Zurück zum Zitat Braune S, Sieweke A, Jarczak D et al (2017) Extrakorporale Verfahren zur Lungenunterstützung. Med Klin Intensivmed Notfallmed 112:426–436CrossRef Braune S, Sieweke A, Jarczak D et al (2017) Extrakorporale Verfahren zur Lungenunterstützung. Med Klin Intensivmed Notfallmed 112:426–436CrossRef
4.
Zurück zum Zitat Brodie D, Curtis JR, Vincent J‑L et al (2017) Treatment limitations in the era of ECMO. Lancet Respir Med 5:769–770CrossRef Brodie D, Curtis JR, Vincent J‑L et al (2017) Treatment limitations in the era of ECMO. Lancet Respir Med 5:769–770CrossRef
5.
Zurück zum Zitat Brummel NE, Bell SP, Girard TD et al (2017) Frailty and subsequent disability and mortality among patients with critical illness. Am J Respir Crit Care Med 196:64–72CrossRef Brummel NE, Bell SP, Girard TD et al (2017) Frailty and subsequent disability and mortality among patients with critical illness. Am J Respir Crit Care Med 196:64–72CrossRef
6.
Zurück zum Zitat Chiumello D, Brochard L, Marini JJ et al (2017) Respiratory support in patients with acute respiratory distress syndrome: an expert opinion. Crit Care 21:240CrossRef Chiumello D, Brochard L, Marini JJ et al (2017) Respiratory support in patients with acute respiratory distress syndrome: an expert opinion. Crit Care 21:240CrossRef
7.
Zurück zum Zitat Combes A, Brodie D, Bartlett R et al (2014) Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients. Am J Respir Crit Care Med 190:488–496CrossRef Combes A, Brodie D, Bartlett R et al (2014) Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients. Am J Respir Crit Care Med 190:488–496CrossRef
8.
Zurück zum Zitat Combes A, Pesenti A, Brodie D (2017) Do we need randomized clinical trials in extracorporeal respiratory support? Yes. Intensive Care Med 43:1862–1865CrossRef Combes A, Pesenti A, Brodie D (2017) Do we need randomized clinical trials in extracorporeal respiratory support? Yes. Intensive Care Med 43:1862–1865CrossRef
9.
Zurück zum Zitat Corsi F, Lebreton G, Bréchot N et al (2017) Life-threatening massive pulmonary embolism rescued by venoarterial-extracorporeal membrane oxygenation. Crit Care 21:76CrossRef Corsi F, Lebreton G, Bréchot N et al (2017) Life-threatening massive pulmonary embolism rescued by venoarterial-extracorporeal membrane oxygenation. Crit Care 21:76CrossRef
10.
Zurück zum Zitat Dangers L, Bréchot N, Schmidt M et al (2017) Extracorporeal membrane oxygenation for acute decompensated heart failure. Crit Care Med 45:1359–1366CrossRef Dangers L, Bréchot N, Schmidt M et al (2017) Extracorporeal membrane oxygenation for acute decompensated heart failure. Crit Care Med 45:1359–1366CrossRef
12.
Zurück zum Zitat Duggal A, Pinto R, Rubenfeld G et al (2016) Global variability in reported mortality for critical illness during the 2009–10 influenza A(H1N1) pandemic: a systematic review and meta-regression to guide reporting of outcomes during disease outbreaks. PLoS ONE 11:e155044CrossRef Duggal A, Pinto R, Rubenfeld G et al (2016) Global variability in reported mortality for critical illness during the 2009–10 influenza A(H1N1) pandemic: a systematic review and meta-regression to guide reporting of outcomes during disease outbreaks. PLoS ONE 11:e155044CrossRef
15.
Zurück zum Zitat Harjola V‑P, Lassus J, Sionis A et al (2015) Clinical picture and risk prediction of short-term mortality in cardiogenic shock. Eur J Heart Fail 17:501–509CrossRef Harjola V‑P, Lassus J, Sionis A et al (2015) Clinical picture and risk prediction of short-term mortality in cardiogenic shock. Eur J Heart Fail 17:501–509CrossRef
16.
Zurück zum Zitat Heringlake M, Bein B, Buerke M et al (2016) Escalation of therapy without evidence: a “may” does not imply a “should”! Intensive Care Med 42:485–487CrossRef Heringlake M, Bein B, Buerke M et al (2016) Escalation of therapy without evidence: a “may” does not imply a “should”! Intensive Care Med 42:485–487CrossRef
17.
Zurück zum Zitat Hilder M, Herbstreit F, Adamzik M et al (2017) Comparison of mortality prediction models in acute respiratory distress syndrome undergoing extracorporeal membrane oxygenation and development of a novel prediction score: the PREdiction of Survival on ECMO Therapy-Score (PRESET-Score). Crit Care 21:301CrossRef Hilder M, Herbstreit F, Adamzik M et al (2017) Comparison of mortality prediction models in acute respiratory distress syndrome undergoing extracorporeal membrane oxygenation and development of a novel prediction score: the PREdiction of Survival on ECMO Therapy-Score (PRESET-Score). Crit Care 21:301CrossRef
18.
Zurück zum Zitat Hodgson CL, Hayes K, Everard T et al (2012) Long-term quality of life in patients with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation for refractory hypoxaemia. Crit Care 16:R202CrossRef Hodgson CL, Hayes K, Everard T et al (2012) Long-term quality of life in patients with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation for refractory hypoxaemia. Crit Care 16:R202CrossRef
19.
Zurück zum Zitat Huesch MD, Foy A, Brehm C (2018) Survival outcomes following the use of extracorporeal membrane oxygenation as a rescue technology in critically ill patients: results from Pennsylvania 2007–2015. Crit Care Med 46:e87–e90CrossRef Huesch MD, Foy A, Brehm C (2018) Survival outcomes following the use of extracorporeal membrane oxygenation as a rescue technology in critically ill patients: results from Pennsylvania 2007–2015. Crit Care Med 46:e87–e90CrossRef
20.
Zurück zum Zitat Isfort M (2017) Evaluation der Pflegebedingungen auf Intensivstationen. Med Klin Intensivmed Notfallmed 112:543–549CrossRef Isfort M (2017) Evaluation der Pflegebedingungen auf Intensivstationen. Med Klin Intensivmed Notfallmed 112:543–549CrossRef
21.
Zurück zum Zitat Karagiannidis C, Brodie D, Strassmann S et al (2016) Extracorporeal membrane oxygenation: evolving epidemiology and mortality. Intensive Care Med 42:889–896CrossRef Karagiannidis C, Brodie D, Strassmann S et al (2016) Extracorporeal membrane oxygenation: evolving epidemiology and mortality. Intensive Care Med 42:889–896CrossRef
22.
Zurück zum Zitat Levesque E, Saliba F, Ichaï P et al (2014) Outcome of patients with cirrhosis requiring mechanical ventilation in ICU. J Hepatol 60:570–578CrossRef Levesque E, Saliba F, Ichaï P et al (2014) Outcome of patients with cirrhosis requiring mechanical ventilation in ICU. J Hepatol 60:570–578CrossRef
23.
Zurück zum Zitat Miller PE, Solomon MA, Mcareavey D (2017) Advanced percutaneous mechanical circulatory support devices for cardiogenic shock. Crit Care Med 45:1922–1929CrossRef Miller PE, Solomon MA, Mcareavey D (2017) Advanced percutaneous mechanical circulatory support devices for cardiogenic shock. Crit Care Med 45:1922–1929CrossRef
24.
Zurück zum Zitat Ouweneel DM, Eriksen E, Seyfarth M et al (2017) Percutaneous mechanical circulatory support versus intra-aortic balloon pump for treating cardiogenic shock: meta-analysis. J Am Coll Cardiol 69:358–360CrossRef Ouweneel DM, Eriksen E, Seyfarth M et al (2017) Percutaneous mechanical circulatory support versus intra-aortic balloon pump for treating cardiogenic shock: meta-analysis. J Am Coll Cardiol 69:358–360CrossRef
25.
Zurück zum Zitat Ouweneel DM, Schotborgh JV, Limpens J et al (2016) Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis. Intensive Care Med 42:1922–1934CrossRef Ouweneel DM, Schotborgh JV, Limpens J et al (2016) Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis. Intensive Care Med 42:1922–1934CrossRef
26.
Zurück zum Zitat Pappalardo F, Pieri M, Greco T et al (2013) Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score. Intensive Care Med 39:275–281CrossRef Pappalardo F, Pieri M, Greco T et al (2013) Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score. Intensive Care Med 39:275–281CrossRef
27.
Zurück zum Zitat Pavasini R, Cirillo C, Campo G et al (2017) Extracorporeal circulatory support in acute coronary syndromes: a systematic review and meta-analysis. Crit Care Med 45:e1173–e1183CrossRef Pavasini R, Cirillo C, Campo G et al (2017) Extracorporeal circulatory support in acute coronary syndromes: a systematic review and meta-analysis. Crit Care Med 45:e1173–e1183CrossRef
28.
Zurück zum Zitat Pichler P, Antretter H, Dünser M et al (2015) Positionspapier der Österreichischen Kardiologischen Gesellschaft zum Einsatz der extrakorporalen Membranoxygenation (ECMO) bei Erwachsenen kardiologischen Patienten. Med Klin Intensivmed Notfallmed 110:407–420CrossRef Pichler P, Antretter H, Dünser M et al (2015) Positionspapier der Österreichischen Kardiologischen Gesellschaft zum Einsatz der extrakorporalen Membranoxygenation (ECMO) bei Erwachsenen kardiologischen Patienten. Med Klin Intensivmed Notfallmed 110:407–420CrossRef
29.
Zurück zum Zitat Pöss J, Köster J, Fuernau G et al (2017) Risk stratification for patients in cardiogenic shock after acute myocardial infarction. J Am Coll Cardiol 69:1913–1920CrossRef Pöss J, Köster J, Fuernau G et al (2017) Risk stratification for patients in cardiogenic shock after acute myocardial infarction. J Am Coll Cardiol 69:1913–1920CrossRef
30.
Zurück zum Zitat Quintel M, Gattinoni L, Weber-Carstens S (2016) The German ECMO inflation: when things other than health and care begin to rule medicine. Intensive Care Med 42:1264–1266CrossRef Quintel M, Gattinoni L, Weber-Carstens S (2016) The German ECMO inflation: when things other than health and care begin to rule medicine. Intensive Care Med 42:1264–1266CrossRef
32.
Zurück zum Zitat Rush B, Wiskar K, Berger L et al (2017) Trends in extracorporeal membrane oxygenation for the treatment of acute respiratory distress syndrome in the United States. J Intensive Care Med 32:535–539CrossRef Rush B, Wiskar K, Berger L et al (2017) Trends in extracorporeal membrane oxygenation for the treatment of acute respiratory distress syndrome in the United States. J Intensive Care Med 32:535–539CrossRef
35.
Zurück zum Zitat Schmidt M, Bailey M, Sheldrake J et al (2014) Predicting survival after extracorporeal membrane oxygenation for severe acute respiratory failure. The respiratory extracorporeal membrane oxygenation survival prediction (RESP) score. Am J Respir Crit Care Med 189:1374–1382CrossRef Schmidt M, Bailey M, Sheldrake J et al (2014) Predicting survival after extracorporeal membrane oxygenation for severe acute respiratory failure. The respiratory extracorporeal membrane oxygenation survival prediction (RESP) score. Am J Respir Crit Care Med 189:1374–1382CrossRef
36.
Zurück zum Zitat Scholz KH, Andresen D, Böttiger BW et al (2017) Qualitätsindikatoren und strukturelle Voraussetzungen für Cardiac-Arrest-Zentren – Deutscher Rat für Wiederbelebung/German Resuscitation Council (GRC). Notf Rettungsmed 20:234–236CrossRef Scholz KH, Andresen D, Böttiger BW et al (2017) Qualitätsindikatoren und strukturelle Voraussetzungen für Cardiac-Arrest-Zentren – Deutscher Rat für Wiederbelebung/German Resuscitation Council (GRC). Notf Rettungsmed 20:234–236CrossRef
37.
Zurück zum Zitat Schwarzkopf D, Ruddel H, Thomas-Ruddel DO et al (2017) Perceived nonbeneficial treatment of patients, burnout, and intention to leave the job among ICU nurses and junior and senior physicians. Crit Care Med 45:e265–e273CrossRef Schwarzkopf D, Ruddel H, Thomas-Ruddel DO et al (2017) Perceived nonbeneficial treatment of patients, burnout, and intention to leave the job among ICU nurses and junior and senior physicians. Crit Care Med 45:e265–e273CrossRef
39.
Zurück zum Zitat Trudzinski FC, Kaestner F, Schäfers H‑J et al (2016) Outcome of patients with interstitial lung disease treated with extracorporeal membrane oxygenation for acute respiratory failure. Am J Respir Crit Care Med 193:527–533CrossRef Trudzinski FC, Kaestner F, Schäfers H‑J et al (2016) Outcome of patients with interstitial lung disease treated with extracorporeal membrane oxygenation for acute respiratory failure. Am J Respir Crit Care Med 193:527–533CrossRef
40.
Zurück zum Zitat Vaquer S, De Haro C, Peruga P et al (2017) Systematic review and meta-analysis of complications and mortality of veno-venous extracorporeal membrane oxygenation for refractory acute respiratory distress syndrome. Ann Intensive Care 7:51CrossRef Vaquer S, De Haro C, Peruga P et al (2017) Systematic review and meta-analysis of complications and mortality of veno-venous extracorporeal membrane oxygenation for refractory acute respiratory distress syndrome. Ann Intensive Care 7:51CrossRef
41.
Zurück zum Zitat Vdovin N, Günther SPW, De Waha S et al (2017) Early risk stratification in patients with cardiogenic shock complicating acute myocardial infarction treated with extracorporeal life support and primary percutaneous coronary intervention. JACC Cardiovasc Interv 10:2469–2471CrossRef Vdovin N, Günther SPW, De Waha S et al (2017) Early risk stratification in patients with cardiogenic shock complicating acute myocardial infarction treated with extracorporeal life support and primary percutaneous coronary intervention. JACC Cardiovasc Interv 10:2469–2471CrossRef
42.
Zurück zum Zitat Wohlfarth P, Beutel G, Lebiedz P et al (2017) Characteristics and outcome of patients after allogeneic hematopoietic stem cell transplantation treated with extracorporeal membrane oxygenation for acute respiratory distress syndrome. Crit Care Med 45:e500–e507CrossRef Wohlfarth P, Beutel G, Lebiedz P et al (2017) Characteristics and outcome of patients after allogeneic hematopoietic stem cell transplantation treated with extracorporeal membrane oxygenation for acute respiratory distress syndrome. Crit Care Med 45:e500–e507CrossRef
43.
Zurück zum Zitat Zapol WM, Snider MT, Hill JD et al (1979) Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study. JAMA 242:2193–2196CrossRef Zapol WM, Snider MT, Hill JD et al (1979) Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study. JAMA 242:2193–2196CrossRef
Metadaten
Titel
Organersatz in der Zukunft
Grenzen und Perspektiven
verfasst von
Prof. Dr. Reimer Riessen
Prof. Dr. Uwe Janssens
Prof. Dr. Stefan John
Prof. Dr. Christian Karagiannidis
Prof. Dr. Stefan Kluge
Publikationsdatum
06.09.2018
Verlag
Springer Vienna
Erschienen in
Wiener klinisches Magazin / Ausgabe 5/2018
Print ISSN: 1869-1757
Elektronische ISSN: 1613-7817
DOI
https://doi.org/10.1007/s00740-018-0244-z

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