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15.09.2015 | Onkologie | Onlineartikel

Further analyses of biomarkers

Immune checkpoint inhibitors have become established as standard therapy for certain subsets of NSCLC patients. Efforts are ongoing to optimise the benefits gained through these drugs, by identification of reliable prognostic and predictive biomarkers, such as PD-L1 expression in tumour cells or infiltrating immune cells, CD8-positive tumour-infiltrating lymphocytes, smoking status, and mutation burden. The necessity for collaboration in this field is obvious; as yet, progress in the area of immuno-oncological biomarkers has been impeded by marked variations with regard to development and reporting (e.g., different cut-offs).

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