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01.06.2014 | original article | Ausgabe 11-12/2014

Wiener klinische Wochenschrift 11-12/2014

Nonalcoholic fatty liver disease: a frequent condition in type 2 diabetic patients

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 11-12/2014
Autoren:
MD, PhD Alexandra Sima, Prof. Romulus Timar, Assoc. Prof. Adrian Vlad, Ass. Prof. Bogdan Timar, Mihaela Rosu, Isabel Dan, Roxana Sirli, Alina Popescu, Ioan Sporea

Summary

Objective

Nonalcoholic fatty liver disease represents an excessive fat accumulation in the liver of patients with no other liver disease and no history of alcohol abuse. It is associated with insulin resistance, being more prevalent in obesity and type 2 diabetes.
Our aim was to assess the prevalence of fatty liver and nonalcoholic steatohepatitis in patients with type 2 diabetes and to evaluate the influence of obesity on its prevalence.

Methods

We included 348 type 2 diabetes patients (age: 18–65 years), without a history of liver disease or alcohol abuse. We assessed demographical data, medical history, physical examination, blood tests, and abdominal ultrasonography.

Results

The prevalence of liver steatosis in our group was 87.1 %, with no significant differences between men and women. Patients with steatosis had higher abdominal circumference, body mass index (BMI; p = 0.001), and serum triglyceride (p < 0.0001), HbA1c (p < 0.001), and alaninaminotranspherase levels (ALT, p = 0.001). The value of BMI, abdominal circumference, and serum triglyceride levels independently influenced the prevalence of liver steatosis; the influence of HbA1c level was not significant. In 23.9 % of the patients with steatosis, we found elevated liver enzymes.

Conclusion

We observed an elevated prevalence of nonalcoholic fatty liver disease (87.1 %) in type 2 diabetic patients. The factors influencing this prevalence are BMI, abdominal circumference,and serum triglyceride levels.

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