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Erschienen in: Wiener klinische Wochenschrift 11-12/2014

01.06.2014 | original article

Nonalcoholic fatty liver disease: a frequent condition in type 2 diabetic patients

verfasst von: MD, PhD Alexandra Sima, Prof. Romulus Timar, Assoc. Prof. Adrian Vlad, Ass. Prof. Bogdan Timar, Mihaela Rosu, Isabel Dan, Roxana Sirli, Alina Popescu, Ioan Sporea

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 11-12/2014

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Summary

Objective

Nonalcoholic fatty liver disease represents an excessive fat accumulation in the liver of patients with no other liver disease and no history of alcohol abuse. It is associated with insulin resistance, being more prevalent in obesity and type 2 diabetes.
Our aim was to assess the prevalence of fatty liver and nonalcoholic steatohepatitis in patients with type 2 diabetes and to evaluate the influence of obesity on its prevalence.

Methods

We included 348 type 2 diabetes patients (age: 18–65 years), without a history of liver disease or alcohol abuse. We assessed demographical data, medical history, physical examination, blood tests, and abdominal ultrasonography.

Results

The prevalence of liver steatosis in our group was 87.1 %, with no significant differences between men and women. Patients with steatosis had higher abdominal circumference, body mass index (BMI; p = 0.001), and serum triglyceride (p < 0.0001), HbA1c (p < 0.001), and alaninaminotranspherase levels (ALT, p = 0.001). The value of BMI, abdominal circumference, and serum triglyceride levels independently influenced the prevalence of liver steatosis; the influence of HbA1c level was not significant. In 23.9 % of the patients with steatosis, we found elevated liver enzymes.

Conclusion

We observed an elevated prevalence of nonalcoholic fatty liver disease (87.1 %) in type 2 diabetic patients. The factors influencing this prevalence are BMI, abdominal circumference,and serum triglyceride levels.
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Metadaten
Titel
Nonalcoholic fatty liver disease: a frequent condition in type 2 diabetic patients
verfasst von
MD, PhD Alexandra Sima
Prof. Romulus Timar
Assoc. Prof. Adrian Vlad
Ass. Prof. Bogdan Timar
Mihaela Rosu
Isabel Dan
Roxana Sirli
Alina Popescu
Ioan Sporea
Publikationsdatum
01.06.2014
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 11-12/2014
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-014-0530-8