No evidence of subgroups found in amphetamine consumers in Iran

Illicit drug use is a global health concern and use of amphetamine-type substances (ATS) is an important contributor to the global burden of disease [6, 7]. The term ATS refers to various forms of stimulant drugs such as methamphetamine, amphetamine, methylenedioxymethamphetamine (MDMA, also known as “ecstasy”), methcathinone, and ephedrine. ATS are the second most commonly used type of illicit drug worldwide after cannabis (UNODC 29). In contrast with opioids, most use of amphetamine-group substances is non-injection. ATSs are most commonly snorted, smoked, or used rectally. Means of administration however varies substantially by region [11, 19]. Use of ATS can persist long term but, compared with opioids, most amphetamine-group substance use remains moderate [10]. In contrast to precursors of cocaine or opioid which can only be grown in regions with suitable climate and soil, amphetamine-group substances can be manufactured anywhere with access to the necessary ingredients. Together with the fact that precursors are widely available and usually cheap, this accounts for the increased use of ATS use worldwide. Is has to be assumed that amphetamine-group substances are manufactured in more than 60 countries [30].

While in Iran, an upper middle-income country with a population of 78 million in the west of Asia, opium and opium residues have historically been the traditional drugs of use [2], an increase of ATS use (with methamphetamine as the most frequently consumed substance) has taken place in recent years [1, 3]. While use of methamphetamines was scarce before 2005 [2, 3], investigations performed a few years later found that almost a quarter of subjects treated for opiate addiction were methamphetamine users [12] and that use had increased from 6% in 2009 to almost 20% in 2011 among former opiate addicts [14]. Despite this increase in certain subgroups, self-reported methamphetamine and ecstasy use has been found to amount to less than 1% in the general population [25].

We assumed that, comparable to alcohol addicts, consumers of ATS also differ in the etiology of their addiction, their consumption behavior and predominantly consume for reasons like seeking stimulation, treating anxiety or depression, or coping with withdrawal. As type I includes subjects who quickly develop physical dependence to the substance in question, we did not expect to find subjects fitting this group in this sample.

In the present investigation we intended to determine whether amphetamine-dependent subjects show differences that form a pattern comparable with that of alcohol dependence. As the Lesch Alcoholism Typology (Table 2) holds several items measuring addiction per se, we applied the Lesch typology to amphetamine addicts supposing that subtyping can be a further step towards the development of individualized treatment.

In the present sample 39 subjects (10 using methamphetamines only and 29 consuming both heroine and methamphetamines) fulfilled the criteria of type II, 75 subjects (25 users of methamphetamine and 50 users of methamphetamines and heroine) corresponded to type III, and 90 subjects met the criteria of type IV (15 users of methamphetamine and 75 users of methamphetamines and heroine). Type I describes the quick development of physical dependence to the substance investigated. As expected, subjects corresponding type I were not present in this sample.

Of the 204 participants, 149 subjects (73%) were male and 55 subjects (27%) were female. Five subjects were younger than 20 years, 183 were between 20 and 50 years old, and 16 were 50 years and older.

The inconsistencies of 39 participants fulfilling the criteria of Type II and 78 subjects using methamphetamine to counteract anxiety as well as 75 participants fulfilling criteria of Type III and 129 subjects trying to treat depressed mood states by means of the drug can be explained by the fact that subjects with a severe depressive disorder would occasionally suffer from anxiety (and would still be Type III) as would subjects with a diagnosis of anxiety disorder sometimes describe depressed mood states (and would still be Type II).

No significant differences in consumption pattern, time of treatment, onset of consumption, addictive disorders among relatives or suicidal tendencies have, however, been detected between the different types.

Amphetamine-type substances, of which methamphetamine is the most frequently used, are more widely consumed than either opioids or cocaine. They are the second most commonly used class of illicit drugs worldwide and although the prevalence rates of current methamphetamine use have been relatively stable in the US in recent years [18], consumption is increasing in east and southeast Asia and the Middle East [30].

At present, treatment options have been limited to psychosocial interventions, most of which however lack evidence [26]. Numerous classes of medication are currently under study, but none has yet been proven to be sufficiently promising [21, 23].

Assuming that subtyping can be a further step towards the development of individualized treatment, this investigation set out to determine whether there are clusters of amphetamine-dependent subjects analogous to those found in alcohol-dependent patients. Other than in nicotine dependence [16] where different clusters of consumption could be found, no such differentiation was detected in our sample of amphetamine-dependent subjects.

Interestingly, however, and comparable to alcohol addiction, many amphetamine-dependent subjects seem to use the substances in order to treat mood disorders or disturbances. While it is known that amphetamines might lead to neurological and functional impairments, facilitating the development of depressive symptomatology [8, 20, 32], we saw that one third of our sample (n = 78) had initially started using amphetamines to treat symptoms of anxiety, while more than half of our subjects (n = 129) had started using amphetamines to treat symptoms of pre-existing depression.

Although articulate affective conditions prior to onset of amphetamine dependence have, to our knowledge, not been described before, these results fit in well with results from pharmacological trials. In these mainly substances targeting dopaminergic, serotonergic, GABAergic and glutamatergic brain pathways have so far been investigated for their potential in the treatment of amphetamine addiction [31]. Among the few substances that have proven promising in reducing methamphetamine use are two antidepressants, namely mirtazapine and buproprion [24]. Like topiramate, which is also being investigated to treat amphetamine addiction, these drugs, however, show efficacy only in certain subgroups [5, 18].

So, even though articulate clusters could not be detected in this investigation it might still be useful to determine whether a patient exhibited symptoms of anxiety disorders (corresponding Type II) or depression (corresponding Type III) prior to the onset of addiction. These groups might benefit from different kinds of medications subject to their underlying condition.

The subgroups investigated here do not correspond to those already described, where consumers are classified into social users and functional users [4, 9, 27], but seem to be associated with underlying psychiatric conditions [13]. Future research that systematically addresses this gap might, thus, be able to provide support for effective treatment development for methamphetamine addiction.

Among the various limitations of this investigation, the cross-sectional character, the small sample size, and the combination of subjects with differing consuming patterns are the most pre-eminent. Furthermore, the questionnaire is a self-rating tool and does not allow conclusions to be drawn on definite psychiatric disorders.

Although we did not identify conclusive evidence of subgroups in amphetamine addicts comparable to those described in alcohol or nicotine dependence, it was however interesting and novel to find such a large extent of reported pre-existing affective conditions prior to their drug use. These findings highlight the need for high quality epidemiological studies and closer monitoring of stimulant use in different populations.