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No evidence for desmocollin 3 to serve as a prognostic marker in primary radiotherapy of head and neck cancer

Zeitschrift:: Wiener klinische Wochenschrift > Ausgabe 1-2/2015

Autoren:: MD Dominik Riss, MD Johannes Pammer, MD, MME Matthaeus C. Grasl, MSc Alexandra Kaider, MD Sven Schneider, MD, PD Boban M. Erovic

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Summary

Purpose

To investigate the role of desmocollin 3 expression in radiation sensitivity and survival in squamous cell carcinoma of the head and neck.

Methods

Tissue samples of 40 patients undergoing primary radiotherapy were stained for desmocollin 3, a transmembrane desmosomal protein. The protein expression was determined by immunohistochemistry. A retrospective chart review was performed to assess overall survival, radiation sensitivity, and disease-free interval.

Results

18 of 40 patients showed desmocollin 3 immunoreactivity. 78 % (14/18) showed radiation sensitivity in the desmocollin 3 positive group, whereas 59 % (13/22) underwent remission in the desmocollin 3 negative group (p = 0.2). The median overall and disease-free survival time was 21 and 26 months, respectively. Univariate and multivariable Cox regression models revealed no statistically significant hazard ratios.

Conclusion

In this cohort of squamous cell carcinoma of the head and neck, we found no evidence for a predictive potential of desmocollin 3.

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Titel: No evidence for desmocollin 3 to serve as a prognostic marker in primary radiotherapy of head and neck cancer
Autoren:: MD Dominik Riss
MD Johannes Pammer
MD, MME Matthaeus C. Grasl
MSc Alexandra Kaider
MD Sven Schneider
MD, PD Boban M. Erovic
Publikationsdatum: 01.01.2015
DOI: https://doi.org/10.1007/s00508-014-0618-1
Verlag: Springer Vienna
Zeitschrift: Wiener klinische Wochenschrift The Central European Journal of Medicine
Ausgabe 1-2/2015
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671

Springer Medizin Österreich

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Summary

Purpose

Methods

Results

Conclusion

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