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Erschienen in: Wiener klinische Wochenschrift 15-16/2020

11.11.2019 | short report

Neutral effect of Glioma-associated oncogene-1 expression on survival in myelofibrosis

verfasst von: MD PhD Marko Lucijanic, Ana Livun, Katarina Marija Tupek, Tajana Stoos-Veic, Vlatko Pejsa, Zeljko Jonjic, Amina Fazlic Dzankic, Marija Ivic, Rajko Kusec

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 15-16/2020

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Summary

This study retrospectively analyzed glioma-associated oncogene 1 (GLI‑1) mRNA expression in unfractionated bone marrow aspirates of 32 patients with myelofibrosis and 16 controls. It was found that GLI‑1 expression did not significantly differ between primary, secondary myelofibrosis and controls (median difference in threshold cycles ∆CT 7.2, 7.3 and 6.9, respectively; P = 0.864), as well as that survival curves of myelofibrosis patients with higher/lower GLI‑1 expression showed multiple overlaps and overall comparable course (P = 0.651). The results suggest that general upregulation of GLI‑1 does not seem to be a feature of the disease and are in line with modest biological and clinical effects observed with inhibitors of Hedgehog signaling pathway in patients with myelofibrosis.

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Metadaten
Titel
Neutral effect of Glioma-associated oncogene-1 expression on survival in myelofibrosis
verfasst von
MD PhD Marko Lucijanic
Ana Livun
Katarina Marija Tupek
Tajana Stoos-Veic
Vlatko Pejsa
Zeljko Jonjic
Amina Fazlic Dzankic
Marija Ivic
Rajko Kusec
Publikationsdatum
11.11.2019
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 15-16/2020
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-019-01572-1