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Erschienen in: neuropsychiatrie 2/2021

09.04.2020 | original article

Neuropsychological functioning among patients with different types of cancer

Postchemotherapy cognitive impairment and implications for rehabilitation

verfasst von: PhD Dr. Kalliopi Megari

Erschienen in: neuropsychiatrie | Ausgabe 2/2021

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Summary

Background

Chemotherapeutic drugs often contribute to the cognitive impairment observed in some individuals following chemotherapy treatment. Postchemotherapy cognitive impairment (PCCI) is referred to as a decline in a variety of neuropsychological measures after chemotherapy and has an acute onset.

Methods

The goals of the present study are to compare the manifestation of longitudinal PCCI among 182 patients with four different types of cancer (breast, colorectal, prostate and thyroid cancer) before chemotherapy (T1), immediately after chemotherapy (T2) and 6 months later (T3).

Results

Although no statistically significant differences were observed between the study groups in any of the cognitive domains before chemotherapy, patients with breast cancer showed significantly lower performance on all cognitive domains compared to other patients at the postchemotherapy timepoints.

Conclusions

Although cognitive difficulties are reported during and after chemotherapy for cancer, it seems that there are differences between different types of cancer. We conclude that it is particularly important to assess and manage these cognitive disorders. Management includes rehabilitation programs that can improve cognitive functions and contribute to changes in brain functions to facilitate this improvement.
Literatur
1.
Zurück zum Zitat Cascella M, Di Napoli R, Carbone D, Cuomo GF, Bimonte S, Muzio MR. Chemotherapy-related cognitive impairment: mechanisms, clinical features and research perspectives. Recenti Prog Med. 2018;109:523–30. PubMed Cascella M, Di Napoli R, Carbone D, Cuomo GF, Bimonte S, Muzio MR. Chemotherapy-related cognitive impairment: mechanisms, clinical features and research perspectives. Recenti Prog Med. 2018;109:523–30. PubMed
2.
Zurück zum Zitat Lambert M, Ouimet LA, Wan C, Stewart A, Collins B, Vitoroulis I, et al. Cancer-related cognitive impairment in breast cancer survivors: An examination of conceptual and statistical cognitive domains using principal component analysis. Oncol Rev. 2018;12:371. PubMedPubMedCentral Lambert M, Ouimet LA, Wan C, Stewart A, Collins B, Vitoroulis I, et al. Cancer-related cognitive impairment in breast cancer survivors: An examination of conceptual and statistical cognitive domains using principal component analysis. Oncol Rev. 2018;12:371. PubMedPubMedCentral
3.
Zurück zum Zitat Heflin LH, Meyerowitz BE, Hall P, Lichtenstein P, Johansson B, Pedersen NL, et al. Cancer as a risk factor for long-term cognitive deficits and dementia. J Natl Cancer Inst. 2005;97:854–6. CrossRef Heflin LH, Meyerowitz BE, Hall P, Lichtenstein P, Johansson B, Pedersen NL, et al. Cancer as a risk factor for long-term cognitive deficits and dementia. J Natl Cancer Inst. 2005;97:854–6. CrossRef
4.
Zurück zum Zitat Lange M, Joly F. How to identify and manage cognitive dysfunction after breast cancer treatment. J Oncol Pract. 2017;13:784–90. CrossRef Lange M, Joly F. How to identify and manage cognitive dysfunction after breast cancer treatment. J Oncol Pract. 2017;13:784–90. CrossRef
5.
Zurück zum Zitat Cerulla N, Arcusa À, Navarro JB, de la Osa N, Garolera M, Enero C et al. Cognitive impairment following chemotherapy for breast cancer: The impact of practice effect on results. J Clin Exp Neuropsychol. 2019;41:290–9. CrossRef Cerulla N, Arcusa À, Navarro JB, de la Osa N, Garolera M, Enero C et al. Cognitive impairment following chemotherapy for breast cancer: The impact of practice effect on results. J Clin Exp Neuropsychol. 2019;41:290–9. CrossRef
6.
Zurück zum Zitat Megari K. Quality of life in chronic disease patients. Health Psych Res. 2013;1:141–8. CrossRef Megari K. Quality of life in chronic disease patients. Health Psych Res. 2013;1:141–8. CrossRef
7.
Zurück zum Zitat Jansen CE, Miaskowski C, Dodd M, Dowling G, Kramer J. A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function. Cancer. 2005;104:2222–33. CrossRef Jansen CE, Miaskowski C, Dodd M, Dowling G, Kramer J. A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function. Cancer. 2005;104:2222–33. CrossRef
8.
Zurück zum Zitat Wefel JS, Saleeba AK, Buzdar AU, Meyers CA. Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer. Cancer. 2010;116:3348–56. CrossRef Wefel JS, Saleeba AK, Buzdar AU, Meyers CA. Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer. Cancer. 2010;116:3348–56. CrossRef
9.
Zurück zum Zitat Khan OF, Cusano E, Raissouni S, Pabia M, Haeseker J, Bosma N, et al. Immediate-term cognitive impairment following intravenous (IV) chemotherapy: a prospective pre-post design study. BMC Cancer. 2019;19:1–9. CrossRef Khan OF, Cusano E, Raissouni S, Pabia M, Haeseker J, Bosma N, et al. Immediate-term cognitive impairment following intravenous (IV) chemotherapy: a prospective pre-post design study. BMC Cancer. 2019;19:1–9. CrossRef
10.
Zurück zum Zitat Collins B, MacKenzie J, Tasca GA, Scherling C, Smith A. Persistent cognitive changes in breast cancer patients1 year following completion of chemotherapy. J Int Neuropsychol Soc. 2014;20:370–9. CrossRef Collins B, MacKenzie J, Tasca GA, Scherling C, Smith A. Persistent cognitive changes in breast cancer patients1 year following completion of chemotherapy. J Int Neuropsychol Soc. 2014;20:370–9. CrossRef
11.
Zurück zum Zitat Khan NF, Mant D, Carpenter L, Forman D, Rose PW. Long-term health outcomes in a British cohort of breast, colorectal and prostate cancer survivors: a database study. Br J Cancer. 2011;105:S29–S37. CrossRef Khan NF, Mant D, Carpenter L, Forman D, Rose PW. Long-term health outcomes in a British cohort of breast, colorectal and prostate cancer survivors: a database study. Br J Cancer. 2011;105:S29–S37. CrossRef
12.
Zurück zum Zitat O’Farrell E, MacKenzie J, Collins B. Clearing the air: a review of our current understanding of “chemo fog”. Curr Oncol Rep. 2013;15:260–9. CrossRef O’Farrell E, MacKenzie J, Collins B. Clearing the air: a review of our current understanding of “chemo fog”. Curr Oncol Rep. 2013;15:260–9. CrossRef
13.
Zurück zum Zitat Ahles TA. Brain vulnerability to chemotherapy toxicities. Psychooncology. 2012;21:1141. CrossRef Ahles TA. Brain vulnerability to chemotherapy toxicities. Psychooncology. 2012;21:1141. CrossRef
15.
Zurück zum Zitat Fardell JE, Vardy J, Johnston IN, Winocur G. Chemotherapy and cognitive impairment: treatment options. Clin Pharmacol Ther. 2011;90:366–76. CrossRef Fardell JE, Vardy J, Johnston IN, Winocur G. Chemotherapy and cognitive impairment: treatment options. Clin Pharmacol Ther. 2011;90:366–76. CrossRef
16.
Zurück zum Zitat Kosmidis ME, Vlahou C, Panagiotaki P, Kioseoglou G. The verbal fluency task in the Greek polulation: normative data, and clustering and switching strategies. J Int Neuropsychol Soc. 2004;10:164–72. CrossRef Kosmidis ME, Vlahou C, Panagiotaki P, Kioseoglou G. The verbal fluency task in the Greek polulation: normative data, and clustering and switching strategies. J Int Neuropsychol Soc. 2004;10:164–72. CrossRef
17.
Zurück zum Zitat Vlahou CH, Kosmidis MH, Dardagani A, Tsotsi S, Giannakou M, Giazkoulidou A, et al. Development of the Greek verbal learning test: reliability, construct validity, and normative standards. Arch Clin Neuropsychol. 2013;28:52–64. CrossRef Vlahou CH, Kosmidis MH, Dardagani A, Tsotsi S, Giannakou M, Giazkoulidou A, et al. Development of the Greek verbal learning test: reliability, construct validity, and normative standards. Arch Clin Neuropsychol. 2013;28:52–64. CrossRef
18.
Zurück zum Zitat Wechsler D. Wechsler Adult Intelligence Scale. 3rd ed. San Antonio: Harcourt Assessment; 1997. Wechsler D. Wechsler Adult Intelligence Scale. 3rd ed. San Antonio: Harcourt Assessment; 1997.
19.
Zurück zum Zitat Benton AL, Tranel D. Visuoperceptual, visuospatial and visuoconstuctive disorders. In: Heilmann KM, Valenstein E, editors. Clinical Neuropsychology. 3rd ed. New York: Oxford University Press; 1993. Benton AL, Tranel D. Visuoperceptual, visuospatial and visuoconstuctive disorders. In: Heilmann KM, Valenstein E, editors. Clinical Neuropsychology. 3rd ed. New York: Oxford University Press; 1993.
20.
Zurück zum Zitat Smith A. Symbol digit modalities test (SDMT). Manual (revised). Los Angeles: Western Psychological Services; 1982. Smith A. Symbol digit modalities test (SDMT). Manual (revised). Los Angeles: Western Psychological Services; 1982.
21.
Zurück zum Zitat Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS Scales. J Pers Soc Psychol. 1988;47:1063–70. CrossRef Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS Scales. J Pers Soc Psychol. 1988;47:1063–70. CrossRef
22.
Zurück zum Zitat Spielberger CD. Manual for the state-trait anxiety inventory (self-evaluation questionnaire). Palo Alto: Consulting Psychologists press; 1970. Spielberger CD. Manual for the state-trait anxiety inventory (self-evaluation questionnaire). Palo Alto: Consulting Psychologists press; 1970.
23.
Zurück zum Zitat Zung WW. A self-rating depression scale. Arch Gen Psychiatry. 1965;12:63–7. CrossRef Zung WW. A self-rating depression scale. Arch Gen Psychiatry. 1965;12:63–7. CrossRef
24.
Zurück zum Zitat Raffa RB. Is a picture worth a thousand (forgotten) words? Neuroimaging evidence for the cognitive deficits in ‘chemo-fog’⁄‘chemo-brain. J Clin Pharm Ther. 2010;35:1–9. CrossRef Raffa RB. Is a picture worth a thousand (forgotten) words? Neuroimaging evidence for the cognitive deficits in ‘chemo-fog’⁄‘chemo-brain. J Clin Pharm Ther. 2010;35:1–9. CrossRef
25.
Zurück zum Zitat Loh SY, Musa AN. Methods to improve rehabilitation of patients following breast cancer surgery: a review of systematic reviews. Breast Cancer. 2015;7:81–98. PubMedPubMedCentral Loh SY, Musa AN. Methods to improve rehabilitation of patients following breast cancer surgery: a review of systematic reviews. Breast Cancer. 2015;7:81–98. PubMedPubMedCentral
26.
Zurück zum Zitat Ercoli LM, Castellon SA, Hunter AM, Kwan L, Kahn-Mills BA, Cernin PA et al. Assessment of the feasibility of a rehabilitation intervention program for breast cancer survivors with cognitive complaints. Brain Imaging Behav. 2013;7:543–53. CrossRef Ercoli LM, Castellon SA, Hunter AM, Kwan L, Kahn-Mills BA, Cernin PA et al. Assessment of the feasibility of a rehabilitation intervention program for breast cancer survivors with cognitive complaints. Brain Imaging Behav. 2013;7:543–53. CrossRef
Metadaten
Titel
Neuropsychological functioning among patients with different types of cancer
Postchemotherapy cognitive impairment and implications for rehabilitation
verfasst von
PhD Dr. Kalliopi Megari
Publikationsdatum
09.04.2020
Verlag
Springer Vienna
Erschienen in
neuropsychiatrie / Ausgabe 2/2021
Print ISSN: 0948-6259
Elektronische ISSN: 2194-1327
DOI
https://doi.org/10.1007/s40211-020-00345-x