Zum Inhalt
Erschienen in:

21.07.2017 | review

Neovascular age-related macular degeneration in Austria

Expert review and introduction to the TargetAMD approach

verfasst von: PD Dr. Ulrike Stolba, Siamak Ansari-Shahrezaei, Stefan Hagen, Martin Stattin, Silvia Schmid, Martina Kropp, Nina Harmening, Gabriele Thumann, TargetAMD Group

Erschienen in: Spektrum der Augenheilkunde | Ausgabe 5/2017

Einloggen, um Zugang zu erhalten

Summary

Age-related macular degeneration (AMD) is the leading cause of blindness in patients over 50 years of age in developed countries. It is estimated that the projected number of people with AMD will be 196 million worldwide by the year 2020, increasing to 288 million by 2040. Of these patients, 10–20% suffering from the fast progressing neovascular form of the disease (nAMD) account for 90% of all cases of severe vision loss. In fact, AMD is responsible for 8.7% of all cases of blindness worldwide. These numbers indicate the substantial burden of the disease. The WHO estimates that 246 million people worldwide currently have low vision and 39 million are blind. A literature (Medline) and Internet research was performed to better understand the prevalence of AMD and how health care could be prepared to cope with it in the future. In 2015, there were 90,010 intravitreal injections (IVI) in Austrian hospitals and primary care units. In 2016, this number rose to >100,000 IVI as the applications increase by approx. 15–20% every year. Since health insurances do not refund IVI in primary care, these services are channeled toward clinical wards, causing overcrowded waiting rooms and dissatisfied patients. Despite this high number of IVI in Austria, real-life data show that the number of IVI given today is not sufficient to keep visual acuity on a steady level. Therefore, new and long-acting treatment options are needed to end the burden for clinics and patients and to increase treatment efficiency by simplified protocols. Herein, a potential new gene-therapeutic approach using nonviral vectors and somatic pigment epithelial cells to overcome the imbalance of pigment epithelium-derived factor and vascular endothelial growth factor in nAMD is described.
Literatur
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
Metadaten
Titel
Neovascular age-related macular degeneration in Austria
Expert review and introduction to the TargetAMD approach
verfasst von
PD Dr. Ulrike Stolba
Siamak Ansari-Shahrezaei
Stefan Hagen
Martin Stattin
Silvia Schmid
Martina Kropp
Nina Harmening
Gabriele Thumann
TargetAMD Group
Publikationsdatum
21.07.2017
Verlag
Springer Vienna
Erschienen in
Spektrum der Augenheilkunde / Ausgabe 5/2017
Print ISSN: 0930-4282
Elektronische ISSN: 1613-7523
DOI
https://doi.org/10.1007/s00717-017-0356-7