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01.04.2017 | case report

Multiple nonsyndromic acquired basal cell carcinomas

Uncommon clinical presentation in a Bulgarian patient

verfasst von: Professor Georgi Tchernev, Ivan Pidakev, PhD, Assoc. Prof. Ilia Lozev, MD, Prof. Dr. Hon.-Prof. Torello Lotti, MD, Prof. Dr. Uwe Wollina

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 5-6/2017

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Summary

Basal cell carcinoma is the most frequent cutaneous neoplasm, with slowly progressive nature and locally invasive behavior. Despite the low metastatic potential, local tissue destruction and disfigurement caused by the tumor can be large if not eradicated in time by early diagnosis and treatment. Both genetic predisposition and exposure to environmental risks are involved in the pathogenesis of the malignant transformation in BCC. The total number of nonmelanocytic skin cancers is a risk factor for recurrence of previous tumor, on the one hand, as well as for the formation of new ones, on the other. It is still unclear what environmental and genetic factors contribute to the development of multiple nonsyndromic BCCs. We present a man with multiple sporadic, nonsyndromic BCCs, with a history of even more lesions, removed earlier, as we discuss the potential triggering risk factors and pathogenic mechanisms of malignant transformation and the further appropriate therapeutic options. The early detection and eradication of these tumors are of importance for treatment effectiveness and quality of life because although rarely metastatic, BCCs could have an aggressive course and behavior which can lead to severe disfiguration and destruction.
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Metadaten
Titel
Multiple nonsyndromic acquired basal cell carcinomas
Uncommon clinical presentation in a Bulgarian patient
verfasst von
Professor Georgi Tchernev
Ivan Pidakev, PhD
Assoc. Prof. Ilia Lozev, MD
Prof. Dr. Hon.-Prof. Torello Lotti, MD
Prof. Dr. Uwe Wollina
Publikationsdatum
01.04.2017
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 5-6/2017
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-017-0545-7