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Erschienen in: Wiener klinische Wochenschrift 11-12/2015

01.06.2015 | case report

Monogenic glucokinase diabetes and pregnancy: a case study

verfasst von: Iva Haladová, MD Daniela Čechurová, MD, PhD Dr. Silvie Lacigová, MD, PhD Prof. Zdeněk Rušavý

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 11-12/2015

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Summary

It is estimated that up to 3 % of patients with gestational diabetes have glucokinase diabetes, termed also maturity-onset diabetes of the young type 2. The disorder has autosomal dominant inheritance. There is a 50 % risk of transmission of the gene to next generation. Two scenarios with different approach to the treatment may occur in pregnancy with glucokinase diabetes: either the fetus inherits the glucokinase mutation and the treatment of maternal hyperglycemia by insulin could increase the risk of fetal growth restriction, or the fetus is without glucokinase gene mutation and untreated hyperglycemia of the mother increases the risk of macrosomia and perinatal morbidity and insulin therapy is necessary. This article describes the outcome of two pregnancies in a patient with monogenic diabetes with glucokinase deficiency. A specific approach to the treatment is discussed.
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Metadaten
Titel
Monogenic glucokinase diabetes and pregnancy: a case study
verfasst von
Iva Haladová
MD Daniela Čechurová
MD, PhD Dr. Silvie Lacigová
MD, PhD Prof. Zdeněk Rušavý
Publikationsdatum
01.06.2015
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 11-12/2015
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-015-0795-6