Skip to main content
Erschienen in: neuropsychiatrie 3/2019

21.01.2019 | review

Migraine headache and depression in adults: a systematic Review and Meta-analysis

verfasst von: Sohrab Amiri, PhD, Sepideh Behnezhad, Esfandiar Azad

Erschienen in: neuropsychiatrie | Ausgabe 3/2019

Einloggen, um Zugang zu erhalten

Summary

Background

Migraines have adverse psychological consequences, one of which is the tendency towards depression. This study aimed to investigate the effects of migraine on adults’ depression in the form of a systematic review and meta-analysis

Methods

Several scientific databases were searched using relevant keywords until the end of January 2018. After reviewing the titles and abstracts and the full texts, the researchers eventually included 16 eligible articles. Major and sub-group analyses were carried out using random effects. Publication bias was also measured.

Results

Pooled Odd Ratio (PR) = 1.95; and 95% confidence interval (CI) = CI = 1.61–2.35 were obtained in studying the effects of migraine on depression. This effect was equal to OR = 1.81 (95% CI = 1.20–2.72) in cohort studies, and OR = 2.00; 95% CI = 1.64–2.43 in cross sectional studies. The heterogeneity was high, and no publication bias was found.

Conclusions

Migraine can play an important role in increasing the incidence of depression in affected patients. Therefore, identifying and ultimately treating the disease can be beneficial in reducing the negative psychological effects of this disease.
Literatur
1.
Zurück zum Zitat Society HCSotIH. The international classification of headache disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.CrossRef Society HCSotIH. The international classification of headache disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.CrossRef
3.
Zurück zum Zitat Prince M, Patel V, Saxena S, et al. No health without mental health. Lancet. 2007;370(9590):859–77.CrossRefPubMed Prince M, Patel V, Saxena S, et al. No health without mental health. Lancet. 2007;370(9590):859–77.CrossRefPubMed
4.
Zurück zum Zitat Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593–602.CrossRefPubMed Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593–602.CrossRefPubMed
5.
Zurück zum Zitat McKnight PE, Kashdan TB. The importance of functional impairment to mental health outcomes: a case for reassessing our goals in depression treatment research. Clin Psychol Rev. 2009;29(3):243–59.CrossRefPubMedPubMedCentral McKnight PE, Kashdan TB. The importance of functional impairment to mental health outcomes: a case for reassessing our goals in depression treatment research. Clin Psychol Rev. 2009;29(3):243–59.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Murrough JW, Iacoviello B, Neumeister A, Charney DS, Iosifescu DV. Cognitive dysfunction in depression: neurocircuitry and new therapeutic strategies. Neurobiol Learn Mem. 2011;96(4):553–63.CrossRefPubMed Murrough JW, Iacoviello B, Neumeister A, Charney DS, Iosifescu DV. Cognitive dysfunction in depression: neurocircuitry and new therapeutic strategies. Neurobiol Learn Mem. 2011;96(4):553–63.CrossRefPubMed
7.
Zurück zum Zitat Papakostas GI, Petersen T, Mahal Y, Mischoulon D, Nierenberg AA, Fava M. Quality of life assessments in major depressive disorder: a review of the literature. Gen Hosp Psychiatry. 2004;26(1):13–7.CrossRefPubMed Papakostas GI, Petersen T, Mahal Y, Mischoulon D, Nierenberg AA, Fava M. Quality of life assessments in major depressive disorder: a review of the literature. Gen Hosp Psychiatry. 2004;26(1):13–7.CrossRefPubMed
8.
Zurück zum Zitat Rugulies R. Depression as a predictor for coronary heart disease. a review and meta-analysis. Am J Prev Med. 2002;23(1):51–61.CrossRefPubMed Rugulies R. Depression as a predictor for coronary heart disease. a review and meta-analysis. Am J Prev Med. 2002;23(1):51–61.CrossRefPubMed
9.
Zurück zum Zitat Mezuk B, Eaton WW, Albrecht S, Golden SH. Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care. 2008;31(12):2383–90.CrossRefPubMedPubMedCentral Mezuk B, Eaton WW, Albrecht S, Golden SH. Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care. 2008;31(12):2383–90.CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Breslau N, Schultz LR, Stewart WF, Lipton RB, Lucia VC, Welch KM. Headache and major depression: is the association specific to migraine? Neurology. 2000;54(2):308–13.CrossRefPubMed Breslau N, Schultz LR, Stewart WF, Lipton RB, Lucia VC, Welch KM. Headache and major depression: is the association specific to migraine? Neurology. 2000;54(2):308–13.CrossRefPubMed
11.
Zurück zum Zitat Breslau N, Lipton RB, Stewart WF, Schultz LR, Welch KM. Comorbidity of migraine and depression: investigating potential etiology and prognosis. Neurology. 2003;60(8):1308–12.CrossRefPubMed Breslau N, Lipton RB, Stewart WF, Schultz LR, Welch KM. Comorbidity of migraine and depression: investigating potential etiology and prognosis. Neurology. 2003;60(8):1308–12.CrossRefPubMed
12.
Zurück zum Zitat Guidetti V, Galli F, Fabrizi P, et al. Headache and psychiatric comorbidity: clinical aspects and outcome in an 8‑year follow-up study. Cephalalgia. 1998;18(7):455–62.CrossRefPubMed Guidetti V, Galli F, Fabrizi P, et al. Headache and psychiatric comorbidity: clinical aspects and outcome in an 8‑year follow-up study. Cephalalgia. 1998;18(7):455–62.CrossRefPubMed
13.
Zurück zum Zitat Jette N, Patten S, Williams J, Becker W, Wiebe S. Comorbidity of migraine and psychiatric disorders—a national population-based study. Headache. 2008;48(4):501–16.CrossRefPubMed Jette N, Patten S, Williams J, Becker W, Wiebe S. Comorbidity of migraine and psychiatric disorders—a national population-based study. Headache. 2008;48(4):501–16.CrossRefPubMed
14.
Zurück zum Zitat Kececi H, Dener S, Analan E. Co-morbidity of migraine and major depression in the Turkish population. Cephalalgia. 2003;23(4):271–5.CrossRefPubMed Kececi H, Dener S, Analan E. Co-morbidity of migraine and major depression in the Turkish population. Cephalalgia. 2003;23(4):271–5.CrossRefPubMed
15.
Zurück zum Zitat Louter MA, Pelzer N, de Boer I, et al. Prevalence of lifetime depression in a large hemiplegic migraine cohort. Neurology. 2016;87(22):2370–4.CrossRefPubMed Louter MA, Pelzer N, de Boer I, et al. Prevalence of lifetime depression in a large hemiplegic migraine cohort. Neurology. 2016;87(22):2370–4.CrossRefPubMed
16.
Zurück zum Zitat Mitsikostas DD, Thomas AM. Comorbidity of headache and depressive disorders. Cephalalgia. 1999;19(4):211–7.CrossRefPubMed Mitsikostas DD, Thomas AM. Comorbidity of headache and depressive disorders. Cephalalgia. 1999;19(4):211–7.CrossRefPubMed
17.
Zurück zum Zitat Santangelo G, Russo A, Trojano L, et al. Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study. J Headache Pain. 2016;17(1):76.CrossRefPubMedPubMedCentral Santangelo G, Russo A, Trojano L, et al. Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study. J Headache Pain. 2016;17(1):76.CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Fasmer OB, Oedegaard KJ. Clinical characteristics of patients with major affective disorders and comorbid migraine. World J Biol Psychiatry. 2001;2(3):149–55.CrossRefPubMed Fasmer OB, Oedegaard KJ. Clinical characteristics of patients with major affective disorders and comorbid migraine. World J Biol Psychiatry. 2001;2(3):149–55.CrossRefPubMed
19.
Zurück zum Zitat Oedegaard KJ, Angst J, Neckelmann D, Fasmer OB. Migraine aura without headache compared to migraine with aura in patients with affective disorders. J Headache Pain. 2005;6(5):378–86.CrossRefPubMedPubMedCentral Oedegaard KJ, Angst J, Neckelmann D, Fasmer OB. Migraine aura without headache compared to migraine with aura in patients with affective disorders. J Headache Pain. 2005;6(5):378–86.CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Ferreira KS, Eckeli A, Dach F, Speciali JG. Comorbidities, medications and depressive symptoms in patients with restless legs syndrome and migraine. Arq Neuropsiquiatr. 2013;71(2):87–91.CrossRefPubMed Ferreira KS, Eckeli A, Dach F, Speciali JG. Comorbidities, medications and depressive symptoms in patients with restless legs syndrome and migraine. Arq Neuropsiquiatr. 2013;71(2):87–91.CrossRefPubMed
21.
Zurück zum Zitat Ortiz A, Cervantes P, Zlotnik G, et al. Cross-prevalence of migraine and bipolar disorder. Bipolar Disord. 2010;12(4):397–403.CrossRefPubMed Ortiz A, Cervantes P, Zlotnik G, et al. Cross-prevalence of migraine and bipolar disorder. Bipolar Disord. 2010;12(4):397–403.CrossRefPubMed
22.
Zurück zum Zitat Torelli P, D’Amico D. An updated review of migraine and co-morbid psychiatric disorders. Ital J Neurol Sci. 2004;25(Suppl 3):S234–5.CrossRef Torelli P, D’Amico D. An updated review of migraine and co-morbid psychiatric disorders. Ital J Neurol Sci. 2004;25(Suppl 3):S234–5.CrossRef
23.
Zurück zum Zitat Merikangas KR, Merikangas JR, Angst J. Headache syndromes and psychiatric disorders: association and familial transmission. J Psychiatr Res. 1993;27(2):197–210.CrossRefPubMed Merikangas KR, Merikangas JR, Angst J. Headache syndromes and psychiatric disorders: association and familial transmission. J Psychiatr Res. 1993;27(2):197–210.CrossRefPubMed
24.
Zurück zum Zitat Radat F, Swendsen J. Psychiatric comorbidity in migraine: a review. Cephalalgia. 2005;25(3):165–78.CrossRefPubMed Radat F, Swendsen J. Psychiatric comorbidity in migraine: a review. Cephalalgia. 2005;25(3):165–78.CrossRefPubMed
25.
26.
Zurück zum Zitat Antonaci F, Nappi G, Galli F, Manzoni GC, Calabresi P, Costa A. Migraine and psychiatric comorbidity: a review of clinical findings. J Headache Pain. 2011;12(2):115–25.CrossRefPubMedPubMedCentral Antonaci F, Nappi G, Galli F, Manzoni GC, Calabresi P, Costa A. Migraine and psychiatric comorbidity: a review of clinical findings. J Headache Pain. 2011;12(2):115–25.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Pompili M, Di Cosimo D, Innamorati M, Lester D, Tatarelli R, Martelletti P. Psychiatric comorbidity in patients with chronic daily headache and migraine: a selective overview including personality traits and suicide risk. J Headache Pain. 2009;10(4):283–90.CrossRefPubMedPubMedCentral Pompili M, Di Cosimo D, Innamorati M, Lester D, Tatarelli R, Martelletti P. Psychiatric comorbidity in patients with chronic daily headache and migraine: a selective overview including personality traits and suicide risk. J Headache Pain. 2009;10(4):283–90.CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Fornaro M, Stubbs B. A meta-analysis investigating the prevalence and moderators of migraines among people with bipolar disorder. J Affect Disord. 2015;178:88–97.CrossRefPubMed Fornaro M, Stubbs B. A meta-analysis investigating the prevalence and moderators of migraines among people with bipolar disorder. J Affect Disord. 2015;178:88–97.CrossRefPubMed
29.
30.
Zurück zum Zitat Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–269, w264.CrossRefPubMed Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–269, w264.CrossRefPubMed
31.
Zurück zum Zitat ICHD. The international classification of headache disorders: 2nd edition. Cephalalgia. 2004;24(Suppl 1):9–160. ICHD. The international classification of headache disorders: 2nd edition. Cephalalgia. 2004;24(Suppl 1):9–160.
32.
Zurück zum Zitat Armijo-Olivo S, Stiles CR, Hagen NA, Biondo PD, Cummings GG. Assessment of study quality for systematic reviews: a comparison of the Cochrane collaboration risk of bias tool and the effective public health practice project quality assessment tool: methodological research. J Eval Clin Pract. 2012;18(1):12–8.CrossRefPubMed Armijo-Olivo S, Stiles CR, Hagen NA, Biondo PD, Cummings GG. Assessment of study quality for systematic reviews: a comparison of the Cochrane collaboration risk of bias tool and the effective public health practice project quality assessment tool: methodological research. J Eval Clin Pract. 2012;18(1):12–8.CrossRefPubMed
33.
Zurück zum Zitat American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Association; 2013.CrossRef American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Association; 2013.CrossRef
34.
Zurück zum Zitat Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–58.CrossRefPubMed Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–58.CrossRefPubMed
36.
Zurück zum Zitat Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088–101.CrossRefPubMed Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088–101.CrossRefPubMed
37.
38.
Zurück zum Zitat Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56(2):455–63.CrossRefPubMed Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56(2):455–63.CrossRefPubMed
39.
Zurück zum Zitat Breslau N, Davis GC, Schultz LR, Paterson EL. Migraine and major depression: a longitudinal study. Headache. 1994;34(7):387–93.CrossRefPubMed Breslau N, Davis GC, Schultz LR, Paterson EL. Migraine and major depression: a longitudinal study. Headache. 1994;34(7):387–93.CrossRefPubMed
40.
Zurück zum Zitat Merikangas KR, Angst J, Isler H. Migraine and psychopathology. Results of the Zurich cohort study of young adults. Arch Gen Psychiatry. 1990;47(9):849–53.CrossRefPubMed Merikangas KR, Angst J, Isler H. Migraine and psychopathology. Results of the Zurich cohort study of young adults. Arch Gen Psychiatry. 1990;47(9):849–53.CrossRefPubMed
41.
Zurück zum Zitat Rist PM, Schurks M, Buring JE, Kurth T. Migraine, headache, and the risk of depression: prospective cohort study. Cephalalgia. 2013;33(12):1017–25.CrossRefPubMedPubMedCentral Rist PM, Schurks M, Buring JE, Kurth T. Migraine, headache, and the risk of depression: prospective cohort study. Cephalalgia. 2013;33(12):1017–25.CrossRefPubMedPubMedCentral
42.
Zurück zum Zitat Swanson SA, Zeng Y, Weeks M, Colman I. The contribution of stress to the comorbidity of migraine and major depression: results from a prospective cohort study. BMJ Open. 2013;3(3):e2057.CrossRefPubMedPubMedCentral Swanson SA, Zeng Y, Weeks M, Colman I. The contribution of stress to the comorbidity of migraine and major depression: results from a prospective cohort study. BMJ Open. 2013;3(3):e2057.CrossRefPubMedPubMedCentral
43.
Zurück zum Zitat Goulart AC, Santos IS, Brunoni AR, et al. Migraine headaches and mood/anxiety disorders in the ELSA Brazil. Headache. 2014;54(8):1310–9.CrossRefPubMed Goulart AC, Santos IS, Brunoni AR, et al. Migraine headaches and mood/anxiety disorders in the ELSA Brazil. Headache. 2014;54(8):1310–9.CrossRefPubMed
44.
Zurück zum Zitat Camarda C, Pipia C, Taglialavori A, Di Fiore P, Camarda R, Monastero R. Comorbidity between depressive symptoms and migraine: preliminary data from the Zabut Aging Project. Ital J Neurol Sci. 2008;29(Suppl 1):S149–S51.CrossRef Camarda C, Pipia C, Taglialavori A, Di Fiore P, Camarda R, Monastero R. Comorbidity between depressive symptoms and migraine: preliminary data from the Zabut Aging Project. Ital J Neurol Sci. 2008;29(Suppl 1):S149–S51.CrossRef
45.
Zurück zum Zitat Kalaydjian A, Eaton W, Zandi P. Migraine headaches are not associated with a unique depressive symptom profile: results from the Baltimore Epidemiologic Catchment Area Study. J Psychosom Res. 2007;63(2):123–9.CrossRefPubMed Kalaydjian A, Eaton W, Zandi P. Migraine headaches are not associated with a unique depressive symptom profile: results from the Baltimore Epidemiologic Catchment Area Study. J Psychosom Res. 2007;63(2):123–9.CrossRefPubMed
46.
Zurück zum Zitat McWilliams LA, Goodwin RD, Cox BJ. Depression and anxiety associated with three pain conditions: results from a nationally representative sample. Pain. 2004;111(1–2):77–83.CrossRefPubMed McWilliams LA, Goodwin RD, Cox BJ. Depression and anxiety associated with three pain conditions: results from a nationally representative sample. Pain. 2004;111(1–2):77–83.CrossRefPubMed
47.
Zurück zum Zitat Molgat CV, Patten SB. Comorbidity of major depression and migraine—a Canadian population-based study. Can J Psychiatry. 2005;50(13):832–7.CrossRefPubMed Molgat CV, Patten SB. Comorbidity of major depression and migraine—a Canadian population-based study. Can J Psychiatry. 2005;50(13):832–7.CrossRefPubMed
48.
Zurück zum Zitat Mattsson P, Ekselius L. Migraine, major depression, panic disorder, and personality traits in women aged 40–74 years: a population-based study. Cephalalgia. 2002;22(7):543–51.CrossRefPubMed Mattsson P, Ekselius L. Migraine, major depression, panic disorder, and personality traits in women aged 40–74 years: a population-based study. Cephalalgia. 2002;22(7):543–51.CrossRefPubMed
49.
Zurück zum Zitat Orta OR, Gelaye B, Qiu C, Stoner L, Williams MA. Depression, anxiety and stress among pregnant migraineurs in a pacific-northwest cohort. J Affect Disord. 2015;172:390–6.CrossRefPubMed Orta OR, Gelaye B, Qiu C, Stoner L, Williams MA. Depression, anxiety and stress among pregnant migraineurs in a pacific-northwest cohort. J Affect Disord. 2015;172:390–6.CrossRefPubMed
50.
Zurück zum Zitat Ratcliffe GE, Enns MW, Jacobi F, Belik S‑L, Sareen J. The relationship between migraine and mental disorders in a population-based sample. Gen Hosp Psychiatry. 2009;31(1):14–9.CrossRefPubMed Ratcliffe GE, Enns MW, Jacobi F, Belik S‑L, Sareen J. The relationship between migraine and mental disorders in a population-based sample. Gen Hosp Psychiatry. 2009;31(1):14–9.CrossRefPubMed
51.
Zurück zum Zitat Risal A, Manandhar K, Holen A, Steiner TJ, Linde M. Comorbidities of psychiatric and headache disorders in Nepal: implications from a nationwide population-based study. J Headache Pain. 2016;17:45.CrossRefPubMedPubMedCentral Risal A, Manandhar K, Holen A, Steiner TJ, Linde M. Comorbidities of psychiatric and headache disorders in Nepal: implications from a nationwide population-based study. J Headache Pain. 2016;17:45.CrossRefPubMedPubMedCentral
52.
Zurück zum Zitat Stam AH, de Vries B, Janssens AC, et al. Shared genetic factors in migraine and depression: evidence from a genetic isolate. Neurology. 2010;74(4):288–94.CrossRefPubMedPubMedCentral Stam AH, de Vries B, Janssens AC, et al. Shared genetic factors in migraine and depression: evidence from a genetic isolate. Neurology. 2010;74(4):288–94.CrossRefPubMedPubMedCentral
53.
Zurück zum Zitat Zwart JA, Dyb G, Hagen K, et al. Depression and anxiety disorders associated with headache frequency. The Nord-Trondelag Health Study. Eur J Neurol. 2003;10(2):147–52.CrossRefPubMed Zwart JA, Dyb G, Hagen K, et al. Depression and anxiety disorders associated with headache frequency. The Nord-Trondelag Health Study. Eur J Neurol. 2003;10(2):147–52.CrossRefPubMed
54.
Zurück zum Zitat Wang SJ, Liu HC, Fuh JL, Liu CY, Wang PN, Lu SR. Comorbidity of headaches and depression in the elderly. Pain. 1999;82(3):239–43.CrossRefPubMed Wang SJ, Liu HC, Fuh JL, Liu CY, Wang PN, Lu SR. Comorbidity of headaches and depression in the elderly. Pain. 1999;82(3):239–43.CrossRefPubMed
Metadaten
Titel
Migraine headache and depression in adults: a systematic Review and Meta-analysis
verfasst von
Sohrab Amiri, PhD
Sepideh Behnezhad
Esfandiar Azad
Publikationsdatum
21.01.2019
Verlag
Springer Vienna
Erschienen in
neuropsychiatrie / Ausgabe 3/2019
Print ISSN: 0948-6259
Elektronische ISSN: 2194-1327
DOI
https://doi.org/10.1007/s40211-018-0299-5

Weitere Artikel der Ausgabe 3/2019

neuropsychiatrie 3/2019 Zur Ausgabe