nach oben

vorheriger Artikel Bewegungs- und Physiotherapie bei Osteoporose

nächster Artikel Mitteilungen des Magnesium- und Osteoporoseforu...

Tipp

Menopausale Hormontherapie 15 Jahre post WHI: Sicherheit geht vor

Zeitschrift:: Journal für Mineralstoffwechsel & Muskuloskelettale Erkrankungen > Ausgabe 1/2018

Autor:: Dr. Ewald Boschitsch

Zusammenfassung

Die Publikation des Östrogen-Gestagen-Arms der WHI-Studie 2002 (WHI: Women’s Health Initiative) war von Fehlinterpretationen der Studienresultate gekennzeichnet. Anhand der Post-WHI-Literatur zur menopausalen Hormontherapie (MHT) werden die tatsächlichen und vermeintlichen Risiken für Brustkrebs, venöse Thromboembolien, Schlaganfall und koronare Herzkrankheit analysiert. Die sich daraus ableitenden Sicherheitsmaßnahmen, wie der Beginn der MHT in der Peri- oder frühen Postmenopause („window of opportunity“), die transdermale Östrogenadministration und die Auswahl eines neutralen Progestogens, können das Risiko minimieren und den Nutzen bei therapeutischen und präventiven Indikationen maximieren.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Jetzt einloggen Kostenlos registrieren

Langer RD (2017) The evidence base for Hormone Replacement Therapy (HRT): what can we believe? Climacteric 20:91–96 CrossRefPubMed

Writing Group for the Women’s Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 288:321–333 CrossRef

The Women’s Health Initiative Study Group (1998) Design of the women’s health initiative clinical trial and observational study. Control Clin Trials 19:61–109 CrossRef

Shapiro S (2003) Risks of estrogen plus progestin therapy: a sensitivity analysis of findings in the Women’s Health Initiative randomized controlled trial. Climacteric 6(4):302–310. (discussion 310–313) CrossRefPubMed

National Institutes of Health (2002) NHLBI stops trial of estrogen plus progestin due to increased breast cancer risk, lack of overall benefit. Press release. http://www.nhlbi.nih.gov/whi/pr_02-7-9.pdf. Zugegriffen: 29. Okt. 2016

Anderson GL, Chlebowski RT, Rossouw JE et al (2006) Prior hormone therapy and breast cancer risk in the Women’s Health Initiative randomized trial of estrogen plus progestin. Maturitas 55:103–115 CrossRefPubMed

Baber RJ, Panay N, Fenton A, Writing Group (2016) IMS Recommendations on women’s midlife health and menopause hormone therapy. Climacteric 19(2):109–150 CrossRefPubMed

Women’s Health Initiative Steering Committee, Anderson GL, Limacher M, Assaf AR et al (2004) Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the women’s health initiative randomized controlled trial. JAMA 291(14):1701–1712 CrossRef

North American Menopause Society (2017) Menopause glossary. https://www.menopause.org/for-women/menopause-glossary. Zugegriffen: 1. Okt. 2017

10.

Fournier A, Berrino F, Clavell-Chapelon F (2008) Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study. Breast Cancer Res Treat 107:103–111 CrossRefPubMed

11.

Cordina-Duverger E, Truong T, Anger A et al (2013) Risk of breast cancer by type of menopausal hormone therapy: a case-control study among post-menopausal women in France. PLOS ONE 8:e78016 CrossRefPubMedPubMedCentral

12.

Lyytinen H, Pukkala E, Ylikorkala O (2009) Breast cancer risk in postmenopausal women using estradiol—progestogen therapy. Obstet Gynecol 113:65–73 CrossRefPubMed

13.

Renoux C, Dell’Aniello S, Suissa S (2010) Hormone replacement therapy and the risk of venous thromboembolism: a population based study. J Thromb Haemost 8:979–986 PubMed

14.

Canonico M, Fournier A, Carcaillon L et al (2010) Postmenopausal hormone therapy and risk of idiopathic venous thromboembolism: results from the E3N cohort study. Arterioscler Thromb Vasc Biol 30:340–345 CrossRefPubMed

15.

Canonico M, Oger E, Conard J et al (2006) Obesity and risk of venous thromboembolism among postmenopausal women: differential impact of hormone therapy by route of estrogen administration. The ESTHER Study. J Thromb Haemost 4:1259–1265 CrossRefPubMed

16.

Canonico M, Alhenc-Gelas M, Plu-Bureau G, Olié V, Scarabin PY (2010) Activated protein C resistance among postmenopausal women using transdermal estrogens: importance of progestogen. Menopause 17(6):1122–1127 CrossRefPubMedPubMedCentral

17.

Olié V, Canonico M, Scarabin PY (2010) Risk of venous thrombosis with oral versus transdermal estrogen therapy among postmenopausal women. Curr Opin Hematol 17(5):457–463 CrossRefPubMed

18.

Henderson VW, Lobo RA (2012) Hormone therapy and the risk of stroke: perspectives 10 years after the Women’s Health Initiative trials. Climacteric 15:229–234 CrossRefPubMedPubMedCentral

19.

Manson JE, Chlebowski RT, Stefanick ML et al (2013) Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women’s Health Initiative randomized trials. JAMA 310:1353–1368 CrossRefPubMed

20.

Boardman HM, Hartley L, Eisinga A et al (2015) Hormone therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD002229.pub4 PubMed

21.

Renoux C, Dell’aniello S, Garbe E et al (2010) Transdermal and oral hormone replacement therapy and the risk of stroke: a nested case-control study. BMJ 340:c2519 CrossRefPubMed

22.

Canonico M, Carcaillon L, Plu-Bureau G, Oger E, Singh-Manoux A, Tubert-Bitter P, Elbaz A, Scarabin PY (2016) Postmenopausal hormone therapy and risk of stroke: impact of the route of estrogen administration and type of progestogen. Stroke 47(7):1734–1741 CrossRefPubMedPubMedCentral

23.

Stampfer MJ, Colditz GA, Willett WC, Manson JE, Rosner B, Speizer FE, Hennekens CH (1991) Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses’ health study. N Engl J Med 325(11):756–762 CrossRefPubMed

24.

Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E (1998) Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 280(7):605–613 CrossRefPubMed

25.

Clarkson TB (1994) Estrogens, progestins, and coronary heart disease in cynomolgus monkeys. Fertil Steril 62(6 Suppl 2):147S–151S PubMed

26.

Adams MR, Williams JK, Clarkson TB, Jayo MJ (1991) Effects of oestrogens and progestogens on coronary atherosclerosis and osteoporosis of monkeys. Baillieres Clin Obstet Gynaecol 5(4):915–934 CrossRefPubMed

27.

Hu P, Greendale GA, Palla SL et al (2006) The effects of hormone therapy on the markers of inflammation and endothelial function and plasma matrix metalloproteinase-9 level in postmenopausal women: the Postmenopausal Estrogen Progestin Intervention (PEPI) trial. Atherosclerosis 185:347–352 CrossRefPubMed

28.

Galis ZS, Sukhova GK, Lark MV, Libby P (1994) Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 94:2493–2503 CrossRefPubMedPubMedCentral

29.

ELITE Research Group, Hodis HN, Mack WJ, Henderson VW et al (2016) Vascular effects of early versus late postmenopausal treatment with estradiol. N Engl J Med 374(13):1221–1231 CrossRef

Titel: Menopausale Hormontherapie 15 Jahre post WHI: Sicherheit geht vor
Autor:: Dr. Ewald Boschitsch
Publikationsdatum: 04.01.2018
DOI: https://doi.org/10.1007/s41970-017-0017-y
Verlag: Springer Vienna
Zeitschrift: Journal für Mineralstoffwechsel & Muskuloskelettale Erkrankungen Osteologie-Rheumatologie-Orthopädie
Ausgabe 1/2018
Print ISSN: 2412-8260
Elektronische ISSN: 2412-8287

Springer Medizin Österreich

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Zusammenfassung

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2018

Zwei Kasuistiken zur Therapie mit Tofacitinib bei rheumatoider Arthritis

Editorial

Fibröse Dysplasie

Bewegungs- und Physiotherapie bei Osteoporose

News-Screen Osteologie

News-Screen Rheumatologie