Skip to main content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: Urologie in der Praxis 1/2019

24.01.2019 | Extended Abstract

Medikamentöse Therapie des benignen Prostatasyndroms – Chemie oder Pflanzen

verfasst von: Mustafa Tutal

Erschienen in: Urologie in der Praxis | Ausgabe 1/2019

Einloggen, um Zugang zu erhalten

Auszug

Bei der Behandlung von Symptomen des unteren Harntraktes im Rahmen eines benignen Prostatasyndroms ist die medikamentöse Therapie eine rasch wirksame und effektive Therapieoption. Hierfür stehen zahlreiche synthetische Medikamente sowie Phytopharmaka zur Verfügung. Die synthetischen Therapeutika können einerseits in der Behandlung der akuten Symptome und andererseits bei einer nachhaltigen Reduktion der Krankheitsprogression wirksam sein. Bei milden bis moderaten Symptomen können Phytopharmaka eine Beschwerdelinderung bringen, bei nahezu nebenwirkungsfreier Anwendung. …
Literatur
1.
Zurück zum Zitat Gratzke C et al (2015) EAU Guidelines on the Assessment of Non-neurogenic Male Lower Urinary Tract Symptoms including Benign Prostatic Obstruction. Eur Urol 67(6):1099–1109 CrossRef Gratzke C et al (2015) EAU Guidelines on the Assessment of Non-neurogenic Male Lower Urinary Tract Symptoms including Benign Prostatic Obstruction. Eur Urol 67(6):1099–1109 CrossRef
2.
Zurück zum Zitat Michel MC, Vrydag W (2006) Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate. Br J Pharmacol 147(Suppl 2):S88–S119 CrossRef Michel MC, Vrydag W (2006) Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate. Br J Pharmacol 147(Suppl 2):S88–S119 CrossRef
3.
Zurück zum Zitat Barendrecht MM et al (2008) Do alpha1-adrenoceptor antagonists improve lower urinary tract symptoms by reducing bladder outlet resistance? Neurourol Urodyn 27:226 CrossRef Barendrecht MM et al (2008) Do alpha1-adrenoceptor antagonists improve lower urinary tract symptoms by reducing bladder outlet resistance? Neurourol Urodyn 27:226 CrossRef
4.
Zurück zum Zitat Chang DF et al (2005) Intraoperative floppy iris syndrome associated with tamsulosin. J Cataract Refract Surg 31:664 CrossRef Chang DF et al (2005) Intraoperative floppy iris syndrome associated with tamsulosin. J Cataract Refract Surg 31:664 CrossRef
5.
Zurück zum Zitat Oelke M, Höfner K, Berges RR, Jonas U (2002) Medikamentöse Therapie des benignen Prostatasyndroms mit α1-Rezeptorblockern. Urologe A 41:425–441 CrossRef Oelke M, Höfner K, Berges RR, Jonas U (2002) Medikamentöse Therapie des benignen Prostatasyndroms mit α1-Rezeptorblockern. Urologe A 41:425–441 CrossRef
6.
Zurück zum Zitat Roehrborn CG, Siami P, Barkin J et al (2010) The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4‑year results from the CombAT study. Eur Urol 57:123–131 CrossRef Roehrborn CG, Siami P, Barkin J et al (2010) The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4‑year results from the CombAT study. Eur Urol 57:123–131 CrossRef
7.
Zurück zum Zitat Naslund MJ et al (2007) A review of the clinical efficacy and safety of 5alpha-reductase inhibitors for the enlarged prostate. Clin Ther 29:17 CrossRef Naslund MJ et al (2007) A review of the clinical efficacy and safety of 5alpha-reductase inhibitors for the enlarged prostate. Clin Ther 29:17 CrossRef
8.
Zurück zum Zitat McConnell JD, Roehrborn CG, Bautista OM et al (2003) The longterm effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med 349:2387–2398 CrossRef McConnell JD, Roehrborn CG, Bautista OM et al (2003) The longterm effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med 349:2387–2398 CrossRef
9.
Zurück zum Zitat Gravas S, Oelke M (2010) Current status of 5alpha-reductase inhibitors in the management of lower urinary tract symptoms and BPH. World J Urol 28:9–15 CrossRef Gravas S, Oelke M (2010) Current status of 5alpha-reductase inhibitors in the management of lower urinary tract symptoms and BPH. World J Urol 28:9–15 CrossRef
10.
Zurück zum Zitat Ückert S, Oelke M (2011) Phospho-diesterase (PDE) inhibitors in the treatment of lower urinary tract dysfunction. Br J Clin Pharmacol 72:197–204 CrossRef Ückert S, Oelke M (2011) Phospho-diesterase (PDE) inhibitors in the treatment of lower urinary tract dysfunction. Br J Clin Pharmacol 72:197–204 CrossRef
11.
Zurück zum Zitat Oelke M, Giuliano F, Mirone V et al (2012) Monotherapy with tadalafil or tamsulosin similarly improved lower urinary tract symptoms suggestive of benign prostatic hyperplasia in an international, randomised, parallel, placebo-controlled clinical trial. Eur Urol 61:917–925 CrossRef Oelke M, Giuliano F, Mirone V et al (2012) Monotherapy with tadalafil or tamsulosin similarly improved lower urinary tract symptoms suggestive of benign prostatic hyperplasia in an international, randomised, parallel, placebo-controlled clinical trial. Eur Urol 61:917–925 CrossRef
12.
Zurück zum Zitat Oelke M, Giuliano F, Baygani SK et al (2014) Treatment satisfaction with tadalafil or tamsulosin vs placebo in men with Lower Urinary Tract Symptoms (LUTS) suggestive of Benign Prostatic Hyperplasia (BPH): results from a randomised, placebo-controlled study. BJU Int 114:568–575 CrossRef Oelke M, Giuliano F, Baygani SK et al (2014) Treatment satisfaction with tadalafil or tamsulosin vs placebo in men with Lower Urinary Tract Symptoms (LUTS) suggestive of Benign Prostatic Hyperplasia (BPH): results from a randomised, placebo-controlled study. BJU Int 114:568–575 CrossRef
13.
Zurück zum Zitat Gacci M, Corona G, Salvi M et al (2012) A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α‑blockers for lower urinary tract symptoms due to benign prostatic hyperplasia. Eur Urol 61:994–1003 CrossRef Gacci M, Corona G, Salvi M et al (2012) A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α‑blockers for lower urinary tract symptoms due to benign prostatic hyperplasia. Eur Urol 61:994–1003 CrossRef
14.
Zurück zum Zitat Kaplan SA, Roehrborn CG, Rovner ES et al (2006) Tolterodine and tamsulosin for treatment of men with lower urinary tract symptoms and overactive bladder. JAMA 296:2319–2328 CrossRef Kaplan SA, Roehrborn CG, Rovner ES et al (2006) Tolterodine and tamsulosin for treatment of men with lower urinary tract symptoms and overactive bladder. JAMA 296:2319–2328 CrossRef
15.
Zurück zum Zitat Chapple CR et al (2013) Randomized double-blind, active-controlled phase 3 study to assess 12-month safety and efficacy of mirabegron, a beta(3)-adrenoceptor agonist, in overactive bladder. Eur Urol 63:296 CrossRef Chapple CR et al (2013) Randomized double-blind, active-controlled phase 3 study to assess 12-month safety and efficacy of mirabegron, a beta(3)-adrenoceptor agonist, in overactive bladder. Eur Urol 63:296 CrossRef
16.
Zurück zum Zitat Oelke M, Martinelli E (2016) Medikamentöse Therapie des benignen Prostatasyndroms. Urologe 55:81–96 CrossRef Oelke M, Martinelli E (2016) Medikamentöse Therapie des benignen Prostatasyndroms. Urologe 55:81–96 CrossRef
17.
Zurück zum Zitat Barkin J, Guimaraes M, Jacobi G et al (2003) Alpha-blocker therapy can be withdrawn in the majority of men following initial combination therapy with the dual 5α-reductase inhibitor dutasteride. Eur Urol 44:461–466 CrossRef Barkin J, Guimaraes M, Jacobi G et al (2003) Alpha-blocker therapy can be withdrawn in the majority of men following initial combination therapy with the dual 5α-reductase inhibitor dutasteride. Eur Urol 44:461–466 CrossRef
18.
Zurück zum Zitat Casabé A, Roehrborn CG, Da Pozzo LF et al (2014) Efficacy and safety of the coadministration of tadalafil once daily with finasteride for 6 months in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia. J Urol 191:727–733 CrossRef Casabé A, Roehrborn CG, Da Pozzo LF et al (2014) Efficacy and safety of the coadministration of tadalafil once daily with finasteride for 6 months in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia. J Urol 191:727–733 CrossRef
19.
Zurück zum Zitat Glina S, Roehrborn CG, Esen A et al (2015) Sexual function in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia: results of a 6-month, randomized, double-blind, placebo-controlled study of tadalafil coadministered with finasteride. J Sex Med 12:129–138 CrossRef Glina S, Roehrborn CG, Esen A et al (2015) Sexual function in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia: results of a 6-month, randomized, double-blind, placebo-controlled study of tadalafil coadministered with finasteride. J Sex Med 12:129–138 CrossRef
21.
Zurück zum Zitat Madersbacher S et al (2008) Plant extracts: sense or nonsense? Curr Opin Urol 18:16 CrossRef Madersbacher S et al (2008) Plant extracts: sense or nonsense? Curr Opin Urol 18:16 CrossRef
23.
Zurück zum Zitat Bach D (2000) Placebokontrollierte Langzeittherapiestudie mit Kürbissamenextrakt bei BPH- bedingten Miktionsbeschwerden. Urologe B 40:437 CrossRef Bach D (2000) Placebokontrollierte Langzeittherapiestudie mit Kürbissamenextrakt bei BPH- bedingten Miktionsbeschwerden. Urologe B 40:437 CrossRef
24.
Zurück zum Zitat Berges R et al (1995) Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 345:1529 CrossRef Berges R et al (1995) Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 345:1529 CrossRef
25.
Zurück zum Zitat Klippel KF et al (1997) A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group. Br J Urol 80:427 CrossRef Klippel KF et al (1997) A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group. Br J Urol 80:427 CrossRef
26.
Zurück zum Zitat Wilt T et al (2000) Beta-sitosterols for benign prostatic hyperplasia. Cochrane Database Syst Rev: Cd001043 Wilt T et al (2000) Beta-sitosterols for benign prostatic hyperplasia. Cochrane Database Syst Rev: Cd001043
27.
Zurück zum Zitat Wilt T et al (2002) Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst Rev: Cd001044 Wilt T et al (2002) Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst Rev: Cd001044
28.
Zurück zum Zitat Carraro JC et al (1996) Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 29:231 CrossRef Carraro JC et al (1996) Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 29:231 CrossRef
29.
Zurück zum Zitat Safarinejad MR (2005) Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J Herb Pharmacother 5:1 CrossRef Safarinejad MR (2005) Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J Herb Pharmacother 5:1 CrossRef
30.
Zurück zum Zitat Lopatkin N et al (2005) Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms—a placebo-controlled, double-blind, multicenter trial. World J Urol 23:139 CrossRef Lopatkin N et al (2005) Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms—a placebo-controlled, double-blind, multicenter trial. World J Urol 23:139 CrossRef
31.
Zurück zum Zitat Sokeland J et al (1997) Combination of Sabal and Urtica extract vs. finasteride in benign prostatic hyperplasia (Aiken stages I to II). Comparison of therapeutic effectiveness in a one year double-blind study. Urologe 36:327 CrossRef Sokeland J et al (1997) Combination of Sabal and Urtica extract vs. finasteride in benign prostatic hyperplasia (Aiken stages I to II). Comparison of therapeutic effectiveness in a one year double-blind study. Urologe 36:327 CrossRef
32.
Zurück zum Zitat Vahlensieck W et al (2015) Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 94:286 CrossRef Vahlensieck W et al (2015) Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 94:286 CrossRef
33.
Zurück zum Zitat Morgia G et al (2014) Serenoa repens, lycopene and selenium versus tamsulosin for the treatment of LUTS/BPH. An Italian multicenter double-blinded randomized study between single or combination therapy (PROCOMB trial). Prostate 74:1471 CrossRef Morgia G et al (2014) Serenoa repens, lycopene and selenium versus tamsulosin for the treatment of LUTS/BPH. An Italian multicenter double-blinded randomized study between single or combination therapy (PROCOMB trial). Prostate 74:1471 CrossRef
34.
Zurück zum Zitat Sokeland J et al (1997) Combination of Sabal and Urtica extract vs. finasteride in benign prostatic hyperplasia (Alken stages I to II). Comparison of therapeutic effectiveness in a one year double-blind study. Urologe A 36:327 CrossRef Sokeland J et al (1997) Combination of Sabal and Urtica extract vs. finasteride in benign prostatic hyperplasia (Alken stages I to II). Comparison of therapeutic effectiveness in a one year double-blind study. Urologe A 36:327 CrossRef
Metadaten
Titel
Medikamentöse Therapie des benignen Prostatasyndroms – Chemie oder Pflanzen
verfasst von
Mustafa Tutal
Publikationsdatum
24.01.2019
Verlag
Springer Vienna
Erschienen in
Urologie in der Praxis / Ausgabe 1/2019
Print ISSN: 2661-8737
Elektronische ISSN: 2661-8745
DOI
https://doi.org/10.1007/s41973-019-0046-y

Weitere Artikel der Ausgabe 1/2019

Urologie in der Praxis 1/2019 Zur Ausgabe

Editorial

Editorial

Editorial

Éditorial